FASN fatty acid synthase [Sus scrofa (pig)] - Gene

Summary

Official Symbol: FASNprovided by VGNC
Official Full Name: fatty acid synthaseprovided by VGNC
Primary source: VGNC:VGNC:88016
See related: Ensembl:ENSSSCG00000029944
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Biased expression in subcutaneous adipose (RPKM 167.6), lung (RPKM 31.1) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 41

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	12	NC_010454.4 (922405..937560)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	12	NC_010454.3 (1023512..1032662, complement)

Chromosome 12 - NC_010454.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We found that FAS knockout caused excessive production of reactive oxygen species (ROS). Excess ROS induced ER stress, resulting in activation of the adaptive unfolded protein response (UPR). FAS knockout caused splicing of the X-box binding protein 1 gene (XBP1) and expression of spliced XBP1 mRNA.
Title: Fatty acid synthase knockout impairs early embryonic development via induction of endoplasmic reticulum stress in pigs.
FASN gene is a promising marker for subcutaneous fat tissue accumulation, while INSIG2 is a promising marker for FA composition
Title: Pig fatness in relation to FASN and INSIG2 genes polymorphism and their transcript level.
In this study, we investigated the FASN gene expression pattern and corresponding DNA methylation status in the inner layer of backfat from Jinhua pigs at different developmental stages.
Title: Promoter and first exon methylation regulate porcine FASN gene expression.
study determined fatty acid synthase crystal structure at 3.2 angstrom resolution covering five catalytic domains; structure reveals a complex architecture of alternating linkers and enzymatic domains
Title: The crystal structure of a mammalian fatty acid synthase.
calculated a 4.5 angstrom-resolution map of fatty acid synthase, and placed homologous template structures of all individual catalytic domains responsible for the cyclic elongation of fatty acid chains into the electron density
Title: Architecture of mammalian fatty acid synthase at 4.5 A resolution.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables fatty acid synthase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables phosphopantetheine binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: fatty acid synthase

NP_001093400.1

EC 2.3.1.85

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001099930.1 → NP_001093400.1 fatty acid synthase

Status: PROVISIONAL

Source sequence(s)

EF589048

UniProtKB/TrEMBL

A0A480M011, A0A8D1K528, A5YV76

Related

ENSSSCP00000021889.3, ENSSSCT00000026033.4

Conserved Domains (11) summary

cd05195
Location:1566 → 1854

enoyl_red; enoyl reductase of polyketide synthase

cd08954
Location:1876 → 2112

KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs

smart00823
Location:2116 → 2180

PKS_PP; Phosphopantetheine attachment site

smart00829
Location:1564 → 1854

PKS_ER; Enoylreductase

COG3321
Location:1 → 1041

PksD; Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]

cd00833
Location:2 → 404

PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...

pfam00698
Location:493 → 810

Acyl_transf_1; Acyl transferase domain

pfam00975
Location:2243 → 2502

Thioesterase; Thioesterase domain

pfam08242
Location:1245 → 1344

Methyltransf_12; Methyltransferase domain

pfam16197
Location:362 → 474

KAsynt_C_assoc; Ketoacyl-synthetase C-terminal extension

cl00509
Location:874 → 1082

hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...