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    PHKG1 phosphorylase kinase catalytic subunit gamma 1 [ Sus scrofa (pig) ]

    Gene ID: 397548, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PHKG1provided by VGNC
    Official Full Name
    phosphorylase kinase catalytic subunit gamma 1provided by VGNC
    Primary source
    VGNC:VGNC:110698
    See related
    Ensembl:ENSSSCG00000007744
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    PHGK
    Expression
    Biased expression in longissimus dorsi muscle (RPKM 64.1), psoas major muscle (RPKM 37.3) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See PHKG1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 3 NC_010445.4 (16822042..16831054)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 3 NC_010445.3 (17074784..17082851)

    Chromosome 3 - NC_010445.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102162776 Neighboring gene nuclear protein 2, transcriptional regulator Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2 Neighboring gene sulfatase modifying factor 2 Neighboring gene chaperonin containing TCP1 subunit 6A Neighboring gene uncharacterized LOC106509672 Neighboring gene transfer RNA lysine (anticodon UUU)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Association between the splice mutation g.8283C>A of the PHKG1 gene and meat quality traits in Large White pigs. Zappaterra M, et al. Meat Sci, 2019 Feb. PMID 30300804
    2. Muscle glycogen level and occurrence of acid meat in commercial hybrid pigs are regulated by two low-frequency causal variants with large effects and multiple common variants with small effects. Liu X, et al. Genet Sel Evol, 2019 Aug 23. PMID 31443641, Free PMC Article
    3. Detection and mapping of mutations in the porcine phosphoglucomutase 1 (PGM1) and phosphorylase kinase gamma unit (PHKG) genes using F-SSCP-analysis. Looft C, et al. Anim Genet, 1999 Jun. PMID 10443001
    4. A splice mutation in the PHKG1 gene causes high glycogen content and low meat quality in pig skeletal muscle. Ma J, et al. PLoS Genet, 2014 Oct. PMID 25340394, Free PMC Article
    5. The regulatory Ser262 of microtubule-associated protein tau is phosphorylated by phosphorylase kinase. Paudel HK. J Biol Chem, 1997 Jan 17. PMID 8999860

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. findings indicate that the genetic basis of muscle residual glycogen in swine can be mainly attributed to two major genes PRKAG3 and PHKG1
      Title: Muscle glycogen level and occurrence of acid meat in commercial hybrid pigs are regulated by two low-frequency causal variants with large effects and multiple common variants with small effects.
    2. The results suggest an effect of PHKG1 g.8283C>A SNP on meat water-holding cap and color in Italian heavy pigs.
      Title: Association between the splice mutation g.8283C>A of the PHKG1 gene and meat quality traits in Large White pigs.
    3. Deep sequencing of PHKG1 revealed a point mutation (C>A) in a splice acceptor site of intron 9, resulting in a 32-bp deletion in the open reading frame and generating a premature stop codon.
      Title: A splice mutation in the PHKG1 gene causes high glycogen content and low meat quality in pig skeletal muscle.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphorylase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glycogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of phosphorylase kinase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
    Names
    phosphorylase kinase gamma 1
    phosphorylase kinase gamma subunit
    NP_001280073.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293144.1 → NP_001280073.1  phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform

      See identical proteins and their annotated locations for NP_001280073.1

      Status: PROVISIONAL

      Source sequence(s)
      KJ481911
      UniProtKB/TrEMBL
      A0A024BTL2, A0A4X1SZ00, A0A8D0S2H2, A0A8D0XR53, A0A8D1K2P5, F1RIU5
      Related
      ENSSSCP00000008272.3, ENSSSCT00000008491.4
      Conserved Domains (2) summary
      smart00220
      Location:20 → 288
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14182
      Location:16 → 291
      STKc_PhKG1; Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma 1 subunit

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010445.4 Reference Sscrofa11.1 Primary Assembly

      Range
      16822042..16831054
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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