GLRX glutaredoxin [Sus scrofa (pig)] - Gene

Summary

Gene symbol: GLRX
Gene description: glutaredoxin
See related: Ensembl:ENSSSCG00000039731
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: TTF; GRX1; GLRX1
Expression: Broad expression in liver (RPKM 77.3), spleen (RPKM 75.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	2	NC_010444.4 (102425580..102437851, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	2	NC_010444.3 (106309433..106321705, complement)

Chromosome 2 - NC_010444.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results indicate that the activation of eNOS/NO system is regulated by Grx 1 and coupled with inhibition of JNK and NF-kappaB signaling pathway which could alleviate the oxidative stress/apoptosis in coronary arteries endothelial cells induced by HG.
Title: Protective effect and mechanism of glutaredoxin 1 on coronary arteries endothelial cells damage induced by high glucose.
Long molecular dynamics simulations and electrostatic calculations were used to analyze the structure, dynamics and electrostatics of reduced pGrx and some of its mutants.
Title: Stabilization of the catalytic thiolate in a mammalian glutaredoxin: structure, dynamics and electrostatics of reduced pig glutaredoxin and its mutants.

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General gene information

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General protein information

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Preferred Names: glutaredoxin-1

Names: TTase-1; thioltransferase; thioltransferase-1

NP_999398.1

EC 1.8.4.1

XP_005655046.1

EC 1.8.4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.