F8 coagulation factor VIII [Sus scrofa (pig)] - Gene

Summary

Official Symbol: F8provided by VGNC
Official Full Name: coagulation factor VIIIprovided by VGNC
Primary source: VGNC:VGNC:87867
See related: Ensembl:ENSSSCG00000012822
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Ubiquitous expression in lung (RPKM 8.9), spleen (RPKM 8.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: X

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	X	NC_010461.5 (125265330..125350853, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	X	NC_010461.4 (143132160..143217828)

Chromosome X - NC_010461.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

It was concluded that VEGF and factor VIII are important growth factors associated with fetal development in pigs and are identified in all uterine segments.
Title: Expression of vascular endothelial growth factor (VEGF) and factor VIII in the gilt placenta and its relation to fetal development.
Report Factor VIII organisation on nanodiscs with different lipid composition.
Title: Factor VIII organisation on nanodiscs with different lipid composition.
cupredoxin-like A1 subdomains in fVIII contain inter-species differences that are a result of selective pressure on the dissociation rate constant
Title: A1 subunit-mediated regulation of thrombin-activated factor VIII A2 subunit dissociation.
thrombin stimulates transglutaminase activity in articular cartilage by directly cleaving factor XIII and by receptor-mediated up-regulation of factor XIII synthesis
Title: Regulation of transglutaminase activity in articular chondrocytes through thrombin receptor-mediated factor XIII synthesis.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables copper ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: coagulation factor VIII

Names: coagulation factor VIII, procoagulant component (hemophilia A); factor VIII; procoagulant component

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214167.2 → NP_999332.2 coagulation factor VIII precursor

Status: VALIDATED

Source sequence(s)

CU914693

UniProtKB/TrEMBL

A0A480HQK2, A0A4X1T893

Related

ENSSSCP00000028556.2, ENSSSCT00000035558.3

Conserved Domains (2) summary

cd00057
Location:1978 → 2127

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cl19115
Location:399 → 575

Cupredoxin; Cupredoxin superfamily