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    HCRT hypocretin neuropeptide precursor [ Sus scrofa (pig) ]

    Gene ID: 397305, updated on 17-Aug-2024

    Summary

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    Official Symbol
    HCRTprovided by VGNC
    Official Full Name
    hypocretin neuropeptide precursorprovided by VGNC
    Primary source
    VGNC:VGNC:88806
    See related
    Ensembl:ENSSSCG00000017410
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Biased expression in ovary (RPKM 2.9), longissimus dorsi muscle (RPKM 0.3) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See HCRT in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 12 NC_010454.4 (20588597..20589991)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 12 NC_010454.3 (20877771..20880147)

    Chromosome 12 - NC_010454.4Genomic Context describing neighboring genes Neighboring gene signal transducer and activator of transcription 3 Neighboring gene signal transducer and activator of transcription 5A Neighboring gene signal transducer and activator of transcription 5B Neighboring gene GH3 domain containing Neighboring gene RAB5C, member RAS oncogene family Neighboring gene heat shock protein family B (small) member 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In summary, we revealed an important role of orexin A in the regulation of pancreatic islets biology. OxA is involved in the secretion of pancreatic hormones and prolongation of islet cell lifespan.
      Title: Orexin A modulates endocrine function and viability of porcine pancreatic islets.
    2. MBH, signal intensity for OXA was highest on days 14-16.
      Title: Expression of orexin A and B in the porcine hypothalamus during the oestrous cycle.
    3. The impact of the phase of the estrous cycle on the observed changes in plasma orexin levels in domestic pigs.
      Title: Changes in plasma orexin A and orexin B concentrations during the estrous cycle of the pig.
    4. Prepro-orexin (PPOX) mRNA abundance was approximately 15-fold higher (P<0.05) in mandibular than in the others salivary glands.
      Title: Differential gene expression and immune localization of the orexin system in the major salivary glands of pigs.
    5. Orexin A was found in the beta cells of cattle, sheep, and swine where it may be implicated in the control of pancreatic activity.
      Title: Immunohistochemical evidence of Orexin-A in the pancreatic beta cells of domestic animals.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in feeding behavior IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hypocretin neuropeptide precursor; orexin
    Names
    orexin-A
    orexin-B
    prepro-orexin
    preprohypocretin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214156.2 → NP_999321.1  hypocretin neuropeptide precursor precursor

      See identical proteins and their annotated locations for NP_999321.1

      Status: PROVISIONAL

      Source sequence(s)
      EF434655
      UniProtKB/Swiss-Prot
      O77668, Q000Y9, Q9TTA6
      Related
      ENSSSCP00000018447.2, ENSSSCT00000018952.5
      Conserved Domains (1) summary
      pfam02072
      Location:1 → 130
      Orexin; Prepro-orexin

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010454.4 Reference Sscrofa11.1 Primary Assembly

      Range
      20588597..20589991
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021066225.1 → XP_020921884.1  orexin isoform X1

      UniProtKB/TrEMBL
      A0A8D0Y162
      Conserved Domains (1) summary
      pfam02072
      Location:67 → 169
      Orexin; Prepro-orexin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O77668.1 GenPept UniProtKB/Swiss-Prot:O77668

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.