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    NR1I2 nuclear receptor subfamily 1 group I member 2 [ Sus scrofa (pig) ]

    Gene ID: 397228, updated on 17-Aug-2024

    Summary

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    Official Symbol
    NR1I2provided by VGNC
    Official Full Name
    nuclear receptor subfamily 1 group I member 2provided by VGNC
    Primary source
    VGNC:VGNC:90873
    See related
    Ensembl:ENSSSCG00000011890
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    PXR
    Expression
    Biased expression in liver (RPKM 31.0), mixtures (RPKM 14.3) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See NR1I2 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 13 NC_010455.5 (140373571..140406129, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 13 NC_010455.4 (149710912..149743466, complement)

    Chromosome 13 - NC_010455.5Genomic Context describing neighboring genes Neighboring gene voltage-dependent anion-selective channel protein 2 pseudogene Neighboring gene G protein-coupled receptor 156 Neighboring gene glycogen synthase kinase 3 beta Neighboring gene cilia and flagella associated protein 91 Neighboring gene cytochrome c oxidase copper chaperone COX17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Characterization of porcine pregnane X receptor, farnesoid X receptor and their splice variants. Gray MA, et al. Exp Biol Med (Maywood), 2010 Jun. PMID 20511676
    2. Comparative genomics of xenobiotic metabolism: a porcine-human PXR gene comparison. Pollock CB, et al. Mamm Genome, 2007 Mar. PMID 17436120
    3. Relationship between CYP3A29 and pregnane X receptor in landrace pigs: Pig CYP3A29 has a similar mechanism of regulation to human CYP3A4. He Y, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2018 Dec. PMID 30153482
    4. IFN-γ regulates cytochrome 3A29 through pregnane X receptor in pigs. Li X, et al. Xenobiotica, 2015 May. PMID 25413352
    5. Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors. Moore LB, et al. Mol Endocrinol, 2002 May. PMID 11981033

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that expression of pregnane X receptor (PXR) is correlated with expression of CYP3A29 in hepatocytes. (CYP3A29 = cytochrome P450 family 3 subfamily A polypeptide 29)
      Title: Relationship between CYP3A29 and pregnane X receptor in landrace pigs: Pig CYP3A29 has a similar mechanism of regulation to human CYP3A4.
    2. The regulatory effect of IFN-gamma on CYP3A29 expression is mediated via PXR.
      Title: IFN-γ regulates cytochrome 3A29 through pregnane X receptor in pigs.
    3. Pregnane X receptor is required for interferon-alpha-mediated CYP3A29 expression, and its expression before CYP3A29.
      Title: Pregnane X receptor is required for IFN-α-mediated CYP3A29 expression in pigs.
    4. In conclusion, PXR and FXR both responded to ligands that activated their human orthologs, and some of the alternatively spliced variants significantly altered PXR and FXR transactivation at in vivo expression levels.
      Title: Characterization of porcine pregnane X receptor, farnesoid X receptor and their splice variants.
    5. the PXR gene revealed multiple splice variants in the ligand-binding domain
      Title: Comparative genomics of xenobiotic metabolism: a porcine-human PXR gene comparison.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclear receptor subfamily 1 group I member 2
    Names
    pregnane X receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038005.1 → NP_001033094.1  nuclear receptor subfamily 1 group I member 2

      See identical proteins and their annotated locations for NP_001033094.1

      Status: PROVISIONAL

      Source sequence(s)
      AB214980
      UniProtKB/TrEMBL
      A5J0K7, F1SPC9, Q2V0W2
      Related
      ENSSSCP00000032044.2, ENSSSCT00000036791.2
      Conserved Domains (2) summary
      cd06934
      Location:129 → 415
      NR_LBD_PXR_like; The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor
      cl02596
      Location:26 → 113
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010455.5 Reference Sscrofa11.1 Primary Assembly

      Range
      140373571..140406129 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_013982406.2 → XP_013837860.1  nuclear receptor subfamily 1 group I member 2 isoform X4

      UniProtKB/TrEMBL
      A0A8D1D2F4
      Conserved Domains (2) summary
      cl02596
      Location:26 → 130
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
      cl11397
      Location:146 → 390
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    2. XM_021068537.1 → XP_020924196.1  nuclear receptor subfamily 1 group I member 2 isoform X6

      UniProtKB/TrEMBL
      A0A288CG33, A0A8D1H9Q7
      Conserved Domains (2) summary
      cl02596
      Location:26 → 130
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
      cl11397
      Location:146 → 356
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    3. XM_013982405.2 → XP_013837859.1  nuclear receptor subfamily 1 group I member 2 isoform X2

      UniProtKB/TrEMBL
      A0A8D1CJ42, A0A8D1YKZ6
      Conserved Domains (2) summary
      cd06934
      Location:126 → 412
      NR_LBD_PXR_like; The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor
      cl02596
      Location:33 → 110
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

    4. XM_021068536.1 → XP_020924195.1  nuclear receptor subfamily 1 group I member 2 isoform X3

      UniProtKB/TrEMBL
      A0A8D1CJ42, A0A8D1YKZ6
      Conserved Domains (2) summary
      cd06934
      Location:109 → 395
      NR_LBD_PXR_like; The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor
      cl02596
      Location:33 → 93
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

    5. XM_005670184.3 → XP_005670241.1  nuclear receptor subfamily 1 group I member 2 isoform X5

      UniProtKB/TrEMBL
      A0A288CG31, A0A4X1T3P8, A0A8D1D2F4
      Related
      ENSSSCP00000012667.3, ENSSSCT00000013009.3
      Conserved Domains (2) summary
      cl02596
      Location:26 → 113
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
      cl11397
      Location:129 → 373
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    6. XM_021068538.1 → XP_020924197.1  nuclear receptor subfamily 1 group I member 2 isoform X7

      UniProtKB/TrEMBL
      A0A287BJM8, A0A4X1T517
      Conserved Domains (2) summary
      cl02596
      Location:26 → 113
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
      cl11397
      Location:129 → 339
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    7. XM_013982404.2 → XP_013837858.1  nuclear receptor subfamily 1 group I member 2 isoform X1

      UniProtKB/TrEMBL
      A0A288CG33, A0A4X1T4L7, A0A8D1H9Q7
      Related
      ENSSSCP00000012669.4, ENSSSCT00000013011.4
      Conserved Domains (2) summary
      cd06934
      Location:146 → 432
      NR_LBD_PXR_like; The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor
      cl02596
      Location:26 → 130
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    Nucleotide Protein
    Heading Accession and Version

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