IGFBP5 insulin like growth factor binding protein 5 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: IGFBP5provided by VGNC
Official Full Name: insulin like growth factor binding protein 5provided by VGNC
Primary source: VGNC:VGNC:96368
See related: Ensembl:ENSSSCG00000025924
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Broad expression in ovary (RPKM 205.1), kidney (RPKM 107.8) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	15	NC_010457.5 (118861816..118877787, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	15	NC_010457.4 (131682267..131684608, complement)

Chromosome 15 - NC_010457.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The present study revealed SNPs in exon 1 of IGFBP-5 gene in the Tibet Mini-pig, possibly providing more understanding of the mechanism of miniaturization
Title: Polymorphism analysis of IGFBP-5 gene exon 1 in Tibet Mini-pig and Junmu No. 1 White pig.
IGFBP-5 gene is associated with the variation in meat quality, especially in pH value together with other QTLs on chromosome 15.
Title: Association of porcine IGF binding protein-5 gene with meat quality.
Endogenous IGFBP-5 or transiently expressed IGFBP-5-EGFP is localized in the nuclei of VSMCs. It possesses transcription-regulatory activity that is IGF independent.
Title: Evidence that IGF binding protein-5 functions as a ligand-independent transcriptional regulator in vascular smooth muscle cells.

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General gene information

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Markers

Igfbp5 (e-PCR), detects polymorphism
- UniSTS:471316

RH75182 (e-PCR)
- UniSTS:85051

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables fibronectin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables insulin-like growth factor I binding	IEA Inferred from Electronic Annotation more info	PubMed
enables insulin-like growth factor II binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: insulin-like growth factor-binding protein 5

Names: IBP-5; IGF-binding protein 5; IGFBP-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.