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    CALCRL calcitonin receptor like receptor [ Sus scrofa (pig) ]

    Gene ID: 397172, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CALCRLprovided by VGNC
    Official Full Name
    calcitonin receptor like receptorprovided by VGNC
    Primary source
    VGNC:VGNC:109487
    See related
    Ensembl:ENSSSCG00000016031
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    CRLR; CGRPR
    Expression
    Broad expression in lung (RPKM 84.9), mixtures (RPKM 12.4) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See CALCRL in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 15 NC_010457.5 (92233264..92332459, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 15 NC_010457.4 (102426205..102522564, complement)

    Chromosome 15 - NC_010457.5Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein SA pseudogene Neighboring gene uncharacterized LOC110257016 Neighboring gene uncharacterized LOC106506297 Neighboring gene tissue factor pathway inhibitor Neighboring gene uncharacterized LOC106507094

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Specificity of porcine calcitonin receptor and calcitonin receptor-like receptor in the presence of receptor-activity-modifying proteins. Kikumoto K, et al. Hypertens Res, 2003 Feb. PMID 12630807
    2. Functional calcitonin gene-related peptide subtype 2 receptors in porcine coronary arteries are identified as calcitonin gene-related peptide subtype 1 receptors by radioligand binding and reverse transcription-polymerase chain reaction. Rorabaugh BR, et al. J Pharmacol Exp Ther, 2001 Dec. PMID 11714898
    3. Adrenomedullin increased the short-circuit current in the pig oviduct through chloride channels via the CGRP receptor: mediation by cAMP and calcium ions but not by nitric oxide. Liao SB, et al. Biol Reprod, 2013 Oct. PMID 23966326
    4. Central and peripheral cardiovascular actions of adrenomedullin 5, a novel member of the calcitonin gene-related peptide family, in mammals. Takei Y, et al. J Endocrinol, 2008 May. PMID 18434369
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that ADM (adrenomedullin) increases oviductal fluid secretion via chloride secretion by calcium and cAMP signal pathways (not nitric oxide signal pathway) via CGRPR (calcitonin gene-related peptide receptor; not adrenomedullin receptor).
      Title: Adrenomedullin increased the short-circuit current in the pig oviduct through chloride channels via the CGRP receptor: mediation by cAMP and calcium ions but not by nitric oxide.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables adrenomedullin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcitonin gene-related peptide receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcitonin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calcitonin gene-related peptide type 1 receptor
    Names
    CGRP type 1 receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214095.1 → NP_999260.1  calcitonin gene-related peptide type 1 receptor precursor

      See identical proteins and their annotated locations for NP_999260.1

      Status: PROVISIONAL

      Source sequence(s)
      AB090162
      UniProtKB/Swiss-Prot
      Q867C1, Q8WN93
      UniProtKB/TrEMBL
      A0A287A7L3, A0A4X1TUL8, A0A8D0TIQ4
      Conserved Domains (2) summary
      pfam02793
      Location:64 → 132
      HRM; Hormone receptor domain
      cd15274
      Location:140 → 403
      7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010457.5 Reference Sscrofa11.1 Primary Assembly

      Range
      92233264..92332459 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021074680.1 → XP_020930339.1  calcitonin gene-related peptide type 1 receptor isoform X1

      UniProtKB/Swiss-Prot
      Q867C1, Q8WN93
      UniProtKB/TrEMBL
      A0A287A7L3, A0A4X1TUL8, A0A8D0TIQ4
      Related
      ENSSSCP00000016986.3, ENSSSCT00000017456.5
      Conserved Domains (2) summary
      pfam02793
      Location:64 → 132
      HRM; Hormone receptor domain
      cd15274
      Location:140 → 403
      7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

    2. XM_005672015.3 → XP_005672072.1  calcitonin gene-related peptide type 1 receptor isoform X1

      See identical proteins and their annotated locations for XP_005672072.1

      UniProtKB/Swiss-Prot
      Q867C1, Q8WN93
      UniProtKB/TrEMBL
      A0A287A7L3, A0A4X1TUL8, A0A8D0TIQ4
      Related
      ENSSSCP00000078386.1, ENSSSCT00000106046.1
      Conserved Domains (2) summary
      pfam02793
      Location:64 → 132
      HRM; Hormone receptor domain
      cd15274
      Location:140 → 403
      7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

    3. XM_013984331.2 → XP_013839785.1  calcitonin gene-related peptide type 1 receptor isoform X1

      UniProtKB/Swiss-Prot
      Q867C1, Q8WN93
      UniProtKB/TrEMBL
      A0A287A7L3, A0A4X1TUL8, A0A8D0TIQ4
      Conserved Domains (2) summary
      pfam02793
      Location:64 → 132
      HRM; Hormone receptor domain
      cd15274
      Location:140 → 403
      7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

    4. XM_005672014.3 → XP_005672071.1  calcitonin gene-related peptide type 1 receptor isoform X1

      See identical proteins and their annotated locations for XP_005672071.1

      UniProtKB/Swiss-Prot
      Q867C1, Q8WN93
      UniProtKB/TrEMBL
      A0A287A7L3, A0A4X1TUL8, A0A8D0TIQ4
      Conserved Domains (2) summary
      pfam02793
      Location:64 → 132
      HRM; Hormone receptor domain
      cd15274
      Location:140 → 403
      7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WN93.1 GenPept UniProtKB/Swiss-Prot:Q8WN93

    Gene LinkOut

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