DLD dihydrolipoamide dehydrogenase [Sus scrofa (pig)] - Gene

Summary

Official Symbol: DLDprovided by VGNC
Official Full Name: dihydrolipoamide dehydrogenaseprovided by VGNC
Primary source: VGNC:VGNC:108580
See related: Ensembl:ENSSSCG00000015443
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: DLDH
Summary: This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In homodimeric form, the protein functions as a dehydrogenase and is found in several multi-enzyme complexes that regulate energy metabolism. However, as a monomer, the protein can function as a protease. [provided by RefSeq, Jan 2014]
Expression: Ubiquitous expression in psoas major muscle (RPKM 140.9), heart (RPKM 138.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	9	NC_010451.4 (107642129..107668443)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	9	NC_010451.3 (118410873..118437344)

Chromosome 9 - NC_010451.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Human, mouse, and pig Dld has moonlighting function as a protease in addition to its canonical function as a a dehydrogenase.
Title: Cryptic proteolytic activity of dihydrolipoamide dehydrogenase.
Lipoamide dehydrogenase significantly accelerates the conversion of a defined subset of NO donors to NO.
Title: Lipoamide dehydrogenase and diaphorase catalyzed conversion of some NO donors to NO and reduction of NO scavenger 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (PTIO).

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables dihydrolipoyl dehydrogenase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	IEA Inferred from Electronic Annotation more info	PubMed
part_of oxoglutarate dehydrogenase complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: dihydrolipoyl dehydrogenase, mitochondrial

Names: lipoamide dehydrogenase

NP_999227.1

EC 1.8.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214062.1 → NP_999227.1 dihydrolipoyl dehydrogenase, mitochondrial precursor

See identical proteins and their annotated locations for NP_999227.1

Status: PROVISIONAL

Source sequence(s)

J03489

UniProtKB/Swiss-Prot

P09623

UniProtKB/TrEMBL

A0A8D0JT66

Related

ENSSSCP00000016374.2, ENSSSCT00000016824.4

Conserved Domains (5) summary

PRK06327
Location:43 → 509

PRK06327; dihydrolipoamide dehydrogenase; Validated

pfam00070
Location:215 → 287

Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase

pfam02852
Location:390 → 496

Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain

cl10013
Location:252 → 393

Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

cl21454
Location:45 → 222

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins