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    DGKA diacylglycerol kinase alpha [ Sus scrofa (pig) ]

    Gene ID: 397097, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DGKAprovided by VGNC
    Official Full Name
    diacylglycerol kinase alphaprovided by VGNC
    Primary source
    VGNC:VGNC:87269
    See related
    Ensembl:ENSSSCG00000000370
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    DAGK; DAGK1
    Expression
    Broad expression in spleen (RPKM 4.9), ovary (RPKM 2.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See DGKA in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 5 NC_010447.5 (21331473..21355614)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 5 NC_010447.4 (22811847..22835786)

    Chromosome 5 - NC_010447.5Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 19 Neighboring gene PYM homolog 1, exon junction complex associated factor Neighboring gene premelanosome protein Neighboring gene cyclin dependent kinase 2 Neighboring gene RAB5B, member RAS oncogene family Neighboring gene uncharacterized LOC110260685

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. The C-terminal part of diacylglycerol kinase alpha lacking zinc fingers serves as a catalytic domain. Sakane F, et al. Biochem J, 1996 Sep 1. PMID 8809050, Free PMC Article
    2. A microsatellite linkage map of the porcine genome. Rohrer GA, et al. Genetics, 1994 Jan. PMID 8138161, Free PMC Article
    3. c-Abl tyrosine kinase regulates serum-induced nuclear export of diacylglycerol kinase α by phosphorylation at Tyr-218. Matsubara T, et al. J Biol Chem, 2012 Feb 17. PMID 22199356, Free PMC Article
    4. Chromosomal assignment of seventeen porcine microsatellites and genes by use of a somatic cell hybrid mapping panel. Rettenberger G, et al. Anim Genet, 1995 Aug. PMID 7661399
    5. Evaluations of the selectivities of the diacylglycerol kinase inhibitors R59022 and R59949 among diacylglycerol kinase isozymes using a new non-radioactive assay method. Sato M, et al. Pharmacology, 2013. PMID 23949095

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the nucleo-cytoplasmic shuttling of DGKalpha is orchestrated by tyrosine phosphorylation by the Src-activated tyrosine kinase c-Abl
      Title: c-Abl tyrosine kinase regulates serum-induced nuclear export of diacylglycerol kinase α by phosphorylation at Tyr-218.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP-dependent diacylglycerol kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in diacylglycerol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lipid phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    diacylglycerol kinase alpha
    Names
    80 kDa diacylglycerol kinase
    DAG kinase alpha
    DGK-alpha
    diglyceride kinase alpha
    NP_999197.1
    XP_005663931.2
    XP_005663932.2
    XP_005663934.1
    XP_020946785.1
    XP_020946786.1
    XP_020946787.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214032.2 → NP_999197.1  diacylglycerol kinase alpha

      See identical proteins and their annotated locations for NP_999197.1

      Status: PROVISIONAL

      Source sequence(s)
      X53256
      UniProtKB/Swiss-Prot
      P20192
      UniProtKB/TrEMBL
      A0A4X1W9U9
      Related
      ENSSSCP00000024792.2, ENSSSCT00000028984.4
      Conserved Domains (5) summary
      smart00045
      Location:519 → 700
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:377 → 498
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:113 → 182
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:205 → 253
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:6 → 109
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010447.5 Reference Sscrofa11.1 Primary Assembly

      Range
      21331473..21355614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021091127.1 → XP_020946786.1  diacylglycerol kinase alpha isoform X4

      UniProtKB/Swiss-Prot
      P20192
      UniProtKB/TrEMBL
      A0A4X1W9U9
      Conserved Domains (5) summary
      smart00045
      Location:519 → 700
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:377 → 498
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:113 → 182
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:205 → 253
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:6 → 109
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    2. XM_021091128.1 → XP_020946787.1  diacylglycerol kinase alpha isoform X5

      Conserved Domains (3) summary
      smart00045
      Location:273 → 454
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:131 → 252
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      pfam00130
      Location:23 → 75
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    3. XM_021091126.1 → XP_020946785.1  diacylglycerol kinase alpha isoform X3

      UniProtKB/TrEMBL
      A0A5S6HQH9, A0A8D0RYJ5, A0A8D1P2G7
      Related
      ENSSSCP00000043702.2, ENSSSCT00000040081.3
      Conserved Domains (5) summary
      smart00045
      Location:570 → 751
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:428 → 549
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:164 → 233
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:256 → 304
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:57 → 160
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    4. XM_005663877.3 → XP_005663934.1  diacylglycerol kinase alpha isoform X4

      See identical proteins and their annotated locations for XP_005663934.1

      UniProtKB/Swiss-Prot
      P20192
      UniProtKB/TrEMBL
      A0A4X1W9U9
      Conserved Domains (5) summary
      smart00045
      Location:519 → 700
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:377 → 498
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:113 → 182
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:205 → 253
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:6 → 109
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    5. XM_005663875.3 → XP_005663932.2  diacylglycerol kinase alpha isoform X2

      UniProtKB/TrEMBL
      A0A2C9F344, A0A480ITE0, A0A8D0PD68, A0A8D1BRT1, A0A8D1WPC1
      Related
      ENSSSCP00000000387.3, ENSSSCT00000000393.4
      Conserved Domains (5) summary
      smart00045
      Location:561 → 742
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:419 → 540
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:155 → 224
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:247 → 295
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:48 → 151
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    6. XM_005663874.3 → XP_005663931.2  diacylglycerol kinase alpha isoform X1

      UniProtKB/TrEMBL
      A0A480KW82
      Conserved Domains (5) summary
      smart00045
      Location:568 → 749
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:426 → 547
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:162 → 231
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:254 → 302
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:55 → 158
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20192.1 GenPept UniProtKB/Swiss-Prot:P20192

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