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    INHBA inhibin subunit beta A [ Sus scrofa (pig) ]

    Gene ID: 397093, updated on 17-Aug-2024

    Summary

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    Official Symbol
    INHBAprovided by VGNC
    Official Full Name
    inhibin subunit beta Aprovided by VGNC
    Primary source
    VGNC:VGNC:89133
    See related
    Ensembl:ENSSSCG00000035077
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Biased expression in ovary (RPKM 6.3), liver (RPKM 6.0) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See INHBA in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 12 NC_010454.4 (53115379..53117128)
    106 current Sscrofa11.1 (GCF_000003025.6) 18 NC_010460.4 (52889684..52909260)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 12 NC_010454.3 (55481493..55483255)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 18 NC_010460.3 (57997858..58017387)

    Chromosome 12 - NC_010454.4Genomic Context describing neighboring genes Neighboring gene transmembrane protein 88 Neighboring gene N-alpha-acetyltransferase 38, NatC auxiliary subunit Neighboring gene uncharacterized LOC102158553 Neighboring gene chromodomain helicase DNA binding protein 3 Neighboring gene uncharacterized LOC100525078 Neighboring gene ring finger protein 227

    Chromosome 18 - NC_010460.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110257601 Neighboring gene uncharacterized LOC102167258 Neighboring gene uncharacterized LOC110257548 Neighboring gene uncharacterized LOC110257602

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Expression of INHβA and INHβB proteins in porcine oocytes cultured in vitro is dependent on the follicle size. Kempisty B, et al. Zygote, 2015 Apr. PMID 24134883, Free PMC Article
    2. Expression and cellular distribution of INHA and INHB before and after in vitro cultivation of porcine oocytes isolated from follicles of different size. Kempisty B, et al. J Biomed Biotechnol, 2012. PMID 23226944, Free PMC Article
    3. Production of inhibin A and inhibin B in boars: changes in testicular and circulating levels of dimeric inhibins and characterization of inhibin forms during testis growth. Ohnuma K, et al. Domest Anim Endocrinol, 2007 Nov. PMID 17010559
    4. Isolation and characterization of native activin B. Nakamura T, et al. J Biol Chem, 1992 Aug 15. PMID 1644823
    5. Complementary DNA sequences of ovarian follicular fluid inhibin show precursor structure and homology with transforming growth factor-beta. Mason AJ, et al. Nature, 1985 Dec 19-1986 Jan 1. PMID 2417121

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An increased expression of Inhibin-beta A was found in oocytes collected from large and medium follicles compared with small follicles before or after in oocyte vitro maturation.
      Title: Expression of INHβA and INHβB proteins in porcine oocytes cultured in vitro is dependent on the follicle size.
    2. INHA and INHB expression and cellular localization in porcine oocytes were studied.
      Title: Expression and cellular distribution of INHA and INHB before and after in vitro cultivation of porcine oocytes isolated from follicles of different size.
    3. results indicated that boar testis produces inhibin A and inhibin B during the infantile period but inhibin A is the predominant form towards puberty and molecular weight forms of inhibin and the sites of production change with testicular development
      Title: Production of inhibin A and inhibin B in boars: changes in testicular and circulating levels of dimeric inhibins and characterization of inhibin forms during testis growth.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in SMAD protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inhibin beta A chain
    Names
    activin beta-A chain
    inhibin beta A subunit
    inhibin beta-subunit
    inhibin, beta A (activin A, activin AB alpha polypeptide)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214028.1 → NP_999193.1  inhibin beta A chain precursor

      See identical proteins and their annotated locations for NP_999193.1

      Status: PROVISIONAL

      Source sequence(s)
      X03266
      UniProtKB/Swiss-Prot
      P03970
      UniProtKB/TrEMBL
      A0A8D0IWS1
      Related
      ENSSSCP00000051495.1, ENSSSCT00000061917.2
      Conserved Domains (2) summary
      smart00204
      Location:319 → 424
      TGFB; Transforming growth factor-beta (TGF-beta) family
      pfam00688
      Location:56 → 291
      TGFb_propeptide; TGF-beta propeptide

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010454.4 Reference Sscrofa11.1 Primary Assembly

      Range
      53115379..53117128
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010460.4 Reference Sscrofa11.1 Primary Assembly

      Range
      52889684..52909260
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P03970.1 GenPept UniProtKB/Swiss-Prot:P03970

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.