FOXO1 forkhead box O1 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: FOXO1provided by VGNC
Official Full Name: forkhead box O1provided by VGNC
Primary source: VGNC:VGNC:98013
See related: Ensembl:ENSSSCG00000009370
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: FOXO1A
Expression: Ubiquitous expression in subcutaneous adipose (RPKM 19.6), ovary (RPKM 16.3) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	11	NC_010453.5 (15317222..15410059, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	11	NC_010453.4 (15548296..15550237, complement)

Chromosome 11 - NC_010453.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FOXO1-suppressed miR-424 regulates both the proliferation and osteogenic differentiation of mesenchymal stem cells via targeting FGF2.
Title: FOXO1-suppressed miR-424 regulates the proliferation and osteogenic differentiation of MSCs by targeting FGF2 under oxidative stress.
Studied the effects of microRNA-27a on myogenin expression and the Akt/FoxO1 signal pathway during porcine myoblast differentiation. Overexpression of miR-27a suppressed myogenin expression during porcine myoblast differentiation, whereas inhibition of miR-27a promoted the mRNA and protein expression levels of myogenin; overexpression of miR-27a decreased the level of P-Akt/Akt and increased the protein level of FoxO1.
Title: Effects of MicroRNA-27a on Myogenin Expression and Akt/FoxO1 Signal Pathway during Porcine Myoblast Differentiation.
he knockdown of FoxO1 repressed lipogenesis by downregulating PDGFRalpha, and miR-34a inhibited adipogenesis through targeting PDGFRalpha.
Title: PDGFRα Regulated by miR-34a and FoxO1 Promotes Adipogenesis in Porcine Intramuscular Preadipocytes through Erk Signaling Pathway.
These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt-mTOR-FOXO1 signaling and suppressing the activation of TLR4 and/or NOD2 signaling pathways.
Title: Glycine enhances muscle protein mass associated with maintaining Akt-mTOR-FOXO1 signaling and suppressing TLR4 and NOD2 signaling in piglets challenged with LPS.
let-7g induces porcine granulosa cells apoptosis by inhibiting the MAP3K1 gene, which promotes FoxO1 expression and dephosphorylation with nuclear accumulation.
Title: Let-7g induces granulosa cell apoptosis by targeting MAP3K1 in the porcine ovary.
inhibition of FoxO1 expression level caused by miR-15a/b over-expression had a positive effect on adipogenesis. Thus, we conclude that miR-15a/b promote adipogenesis in porcine pre-adipocyte via repressing FoxO1
Title: MiR-15a/b promote adipogenesis in porcine pre-adipocyte via repressing FoxO1.
Results show that FoxO1 likely regulates MyHC I negatively and MyHC IIx and MyHC IIb positively and may play a pivotal role in the determination of muscle fiber type.
Title: Correlation of forkhead box transcription factor O1 and myosin heavy chain isoforms in porcine skeletal muscle.
Data suggest forkhead box protein O1 (FoxO1) involvement in the regulation of TNF-related apoptosis-inducing ligand TRAIL and Fas ligand FasL expression during follicular atresia.
Title: Changes in the expression of Fox O1 and death ligand genes during follicular atresia in porcine ovary.
Data show that IL-4 induces upregulation of the junction protein claudin-5 in endothelial cells (ECs) through activation of Jak/STAT6 and phosphorylation and translocation of FoxO1 from the nucleus to the cytoplasm.
Title: Interleukin-4 induces up-regulation of endothelial cell claudin-5 through activation of FoxO1: role in protection from complement-mediated injury.
FoxO1 and C/EBPb regulate preadipocyte adipogenesis possibly through C/EBPb-> FoxO1-> C/EBPb feedback regulatory loop and FoxO1-C/EBPb protein complex.
Title: Knockdown of both FoxO1 and C/EBPβ promotes adipogenesis in porcine preadipocytes through feedback regulation.

Submit: New GeneRIF Correction See all GeneRIFs (15)

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: forkhead box protein O1

Names: Forkhead box protein O1A; Forkhead in rhabdomyosarcoma; forkhead box O1A (rhabdomyosarcoma); forkhead/winged helix transcription factor FOXO1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214014.3 → NP_999179.3 forkhead box protein O1

Status: VALIDATED

Source sequence(s)

AEMK02000075, AK234453, AY094061, BX920024

UniProtKB/TrEMBL

A0A4X1SRX5, A0A8D0XRP5, F1RME6, K7GPH8

Conserved Domains (3) summary

cd00059
Location:167 → 247

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam16675
Location:430 → 507

FOXO_KIX_bdg; KIX-binding domain of forkhead box O, CR2

pfam16676
Location:604 → 640

FOXO-TAD; Transactivation domain of FOXO protein family

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

NC_010453.5 Reference Sscrofa11.1 Primary Assembly

Range

15317222..15410059 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021065269.1 → XP_020920928.1 forkhead box protein O1

Related

ENSSSCP00000029792.2, ENSSSCT00000035744.3

Conserved Domains (3) summary

cd00059
Location:167 → 247

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam16675
Location:430 → 507

FOXO_KIX_bdg; KIX-binding domain of forkhead box O, CR2

pfam16676
Location:604 → 640

FOXO-TAD; Transactivation domain of FOXO protein family