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    ITGB2 integrin subunit beta 2 [ Sus scrofa (pig) ]

    Gene ID: 396943, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ITGB2provided by VGNC
    Official Full Name
    integrin subunit beta 2provided by VGNC
    Primary source
    VGNC:VGNC:89242
    See related
    Ensembl:ENSSSCG00000025133
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    CD18
    Expression
    Biased expression in spleen (RPKM 210.1), lung (RPKM 143.1) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See ITGB2 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 13 NC_010455.5 (207514281..207544108, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 13 NC_010455.4 (217446055..217475887, complement)

    Chromosome 13 - NC_010455.5Genomic Context describing neighboring genes Neighboring gene small ubiquitin like modifier 3 Neighboring gene PTTG1 interacting protein Neighboring gene eukaryotic translation initiation factor 4 gamma 2 pseudogene Neighboring gene SLX9 ribosome biogenesis factor Neighboring gene serine/threonine-protein kinase WNK4-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Porcine CD18 mediates Actinobacillus pleuropneumoniae ApxIII species-specific toxicity. Vanden Bergh PG, et al. Vet Res, 2009 Jul-Aug. PMID 19356397, Free PMC Article
    2. Dynamic expression of the signal regulatory protein alpha and CD18 on porcine PBMC during acute endotoxaemia. Ebdrup L, et al. Scand J Immunol, 2008 Oct. PMID 18782273
    3. Zona pellucida glycoprotein 3 (pZP3) and integrin β2 (ITGB2) mRNA and protein expression in porcine oocytes after single and double exposure to brilliant cresyl blue test. Kempisty B, et al. Theriogenology, 2011 May. PMID 21295838
    4. Cell type-specific differences in β-glucan recognition and signalling in porcine innate immune cells. Baert K, et al. Dev Comp Immunol, 2015 Jan. PMID 25453580
    5. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CR3 plays a cardinal role in beta-glucan signalling in porcine neutrophils, while macrophages use a more diverse receptor array to detect and respond towards beta-glucans.
      Title: Cell type-specific differences in β-glucan recognition and signalling in porcine innate immune cells.
    2. The expression of zona pellucida glycoprotein 3 and integrin beta-2 in oocytes after brilliant cresyl blue staining is reported.
      Title: Zona pellucida glycoprotein 3 (pZP3) and integrin β2 (ITGB2) mRNA and protein expression in porcine oocytes after single and double exposure to brilliant cresyl blue test.
    3. It is concluded that porcine CD18 is necessary to mediate A. pleuropneumoniae ApxIIIA toxin-induced leukolysis.
      Title: Porcine CD18 mediates Actinobacillus pleuropneumoniae ApxIII species-specific toxicity.
    4. early CD18 downregulation is profitable for the host in a situation with an intense LPS stimulus
      Title: Dynamic expression of the signal regulatory protein alpha and CD18 on porcine PBMC during acute endotoxaemia.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables amyloid-beta binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables integrin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion mediated by integrin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of integrin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    integrin beta-2
    Names
    CD18 leukocyte adhesion molecule
    cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta
    complement receptor C3 subunit beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213908.1 → NP_999073.1  integrin beta-2 precursor

      See identical proteins and their annotated locations for NP_999073.1

      Status: PROVISIONAL

      Source sequence(s)
      U13941
      UniProtKB/Swiss-Prot
      P53714
      UniProtKB/TrEMBL
      A0A4X1T967, A8DSD5
      Related
      ENSSSCP00000043125.1, ENSSSCT00000058128.3
      Conserved Domains (3) summary
      smart00187
      Location:32 → 447
      INB; Integrin beta subunits (N-terminal portion of extracellular region)
      pfam07965
      Location:622 → 699
      Integrin_B_tail; Integrin beta tail domain
      pfam08725
      Location:726 → 766
      Integrin_b_cyt; Integrin beta cytoplasmic domain

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010455.5 Reference Sscrofa11.1 Primary Assembly

      Range
      207514281..207544108 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53714.1 GenPept UniProtKB/Swiss-Prot:P53714

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials