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    ORM1 orosomucoid 1 [ Sus scrofa (pig) ]

    Gene ID: 396901, updated on 16-Nov-2023

    Summary

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    Gene symbol
    ORM1
    Gene description
    orosomucoid 1
    See related
    Ensembl:ENSSSCG00000005488
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    AGP
    Expression
    Biased expression in liver (RPKM 1696.2) and mixtures (RPKM 660.6) See more
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    Genomic context

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    See ORM1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 1 NC_010443.5 (254939154..254943065)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 1 NC_010443.4 (286190518..286194344)

    Chromosome 1 - NC_010443.5Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106509240 Neighboring gene collagen type XXVII alpha 1 chain Neighboring gene microRNA mir-455 Neighboring gene uncharacterized LOC110256124 Neighboring gene AT-hook transcription factor Neighboring gene whirlin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Regulation of alpha-1 acid glycoprotein synthesis by porcine hepatocytes in monolayer culture. Caperna TJ, et al. Domest Anim Endocrinol, 2015 Jul. PMID 25839994
    2. Pig α1-acid glycoprotein: characterization and first description in any species as a negative acute phase protein. Heegaard PM, et al. PLoS One, 2013. PMID 23844161, Free PMC Article
    3. Orosomucoid expression profiles in liver, adipose tissues and serum of lean and obese domestic pigs, Göttingen minipigs and Ossabaw minipigs. Rødgaard T, et al. Vet Immunol Immunopathol, 2013 Feb 15. PMID 23254161
    4. Identification of alpha-1 acid glycoprotein (AGP) as a potential marker of impaired growth in the newborn piglet. Caperna TJ, et al. Reprod Fertil Dev, 2013. PMID 23174131
    5. Assignment of alpha 1-acid glycoprotein gene (ORM1) to swine chromosome region 1q210-->q212 by fluorescence in situ hybridization. Murakami Y, et al. Cytogenet Cell Genet, 1995. PMID 7789167

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. data support the consideration that alpha-1 acid glycoprotein is a negative acute-phase reactant and appears to be regulated by cytokines
      Title: Regulation of alpha-1 acid glycoprotein synthesis by porcine hepatocytes in monolayer culture.
    2. Data suggest that AGP/ORM1 level in blood at birth is reflective of growth conditions in utero or fetal maturation and may serve as an early predictive biomarker for pre-weaning growth rate.
      Title: Identification of alpha-1 acid glycoprotein (AGP) as a potential marker of impaired growth in the newborn piglet.
    3. Data indicate decreases in serum alpha-1 acid glycoprotein concentration and in hepatic ORM1 expression during the acute phase response.
      Title: Pig α1-acid glycoprotein: characterization and first description in any species as a negative acute phase protein.
    4. expression of ORM1 mRNA in liver, adipose tissue well as the serum concentration of ORM protein in three porcine obesity models; the domestic pig, Gottingen minipigs and Ossabaw minipigs
      Title: Orosomucoid expression profiles in liver, adipose tissues and serum of lean and obese domestic pigs, Göttingen minipigs and Ossabaw minipigs.
    5. This study suggested closer links between the release of haptoglobin, Pig-MAP and monocytes compared to the release of AGP, SAA and transthyretin.
      Title: The association between plasma levels of acute phase proteins, haptoglobin, alpha-1 acid glycoprotein (AGP), pig-MAP, transthyretin and serum amyloid A (SAA) in Large White and Meishan pigs.
    6. involvement in the detection of appeasing compounds in the nasal mucosa and the vomeronasal organ of pre-pubertal pigs
      Title: Functional characterization of olfactory binding proteins for appeasing compounds and molecular cloning in the vomeronasal organ of pre-pubertal pigs.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in regulation of immune system process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alpha-1-acid glycoprotein
    Names
    alpha-1 acid glycoprotein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010443.5 Reference Sscrofa11.1 Primary Assembly

      Range
      254939154..254943065
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005660372.3 → XP_005660429.1  alpha-1-acid glycoprotein isoform X2

      See identical proteins and their annotated locations for XP_005660429.1

      UniProtKB/TrEMBL
      A0A480TCL8, A0A8D0RQY2, F1SN68
      Related
      ENSSSCP00000005884.2, ENSSSCT00000006034.5
      Conserved Domains (1) summary
      pfam00061
      Location:40 → 180
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    2. XM_005660371.3 → XP_005660428.1  alpha-1-acid glycoprotein isoform X1

      UniProtKB/TrEMBL
      A0A5G2R0I4, A0A8D0MRP4, A0A8D0RSL3, A0A8D1VN53
      Related
      ENSSSCP00000070617.1, ENSSSCT00000083776.1
      Conserved Domains (1) summary
      pfam00061
      Location:40 → 180
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    3. XM_021067967.1 → XP_020923626.1  alpha-1-acid glycoprotein isoform X3

      UniProtKB/TrEMBL
      A0A480TCL8
      Conserved Domains (1) summary
      pfam00061
      Location:40 → 180
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
    Nucleotide Protein
    Heading Accession and Version

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