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    INHCA inhibitor of carbonic anhydrase [ Sus scrofa (pig) ]

    Gene ID: 396845, updated on 17-Aug-2024

    Summary

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    Official Symbol
    INHCAprovided by VGNC
    Official Full Name
    inhibitor of carbonic anhydraseprovided by VGNC
    Primary source
    VGNC:VGNC:109177
    See related
    Ensembl:ENSSSCG00000028203
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    ICA; PICA
    Expression
    Biased expression in liver (RPKM 277.2), mixtures (RPKM 101.4) and 1 other tissue See more
    Orthologs
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    Genomic context

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    See INHCA in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 13 NC_010455.5 (74862502..74907059)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 13 NC_010455.4 (82342763..82405393)

    Chromosome 13 - NC_010455.5Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110256300 Neighboring gene DNA topoisomerase II binding protein 1 Neighboring gene profilin-1 pseudogene Neighboring gene transferrin Neighboring gene SRP receptor subunit beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Cloning, sequencing, and recombinant expression of the porcine inhibitor of carbonic anhydrase: a novel member of the transferrin family. Wuebbens MW, et al. Biochemistry, 1997 Apr 8. PMID 9100029
    2. Purification and characterization of a carbonic anhydrase II inhibitor from porcine plasma. Roush ED, et al. Biochemistry, 1992 Dec 15. PMID 1463741
    3. Porcine transcriptome analysis based on 97 non-normalized cDNA libraries and assembly of 1,021,891 expressed sequence tags. Gorodkin J, et al. Genome Biol, 2007. PMID 17407547, Free PMC Article
    4. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in antibacterial humoral response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inhibitor of carbonic anhydrase
    Names
    porcine inhibitor of carbonic anhydrase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213847.2 → NP_999012.2  inhibitor of carbonic anhydrase precursor

      Status: VALIDATED

      Source sequence(s)
      AK233074, EW545146, FP236210
      UniProtKB/TrEMBL
      A0A8D1LP75
      Related
      ENSSSCP00000021371.2, ENSSSCT00000027958.4
      Conserved Domains (2) summary
      cd13617
      Location:355 → 688
      PBP2_transferrin_C; The C-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily
      cd13618
      Location:24 → 346
      PBP2_transferrin_N; The N-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010455.5 Reference Sscrofa11.1 Primary Assembly

      Range
      74862502..74907059
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021068520.1 → XP_020924179.1  inhibitor of carbonic anhydrase isoform X1

      UniProtKB/TrEMBL
      A0A8D0YK12, I3LBF1
      Conserved Domains (2) summary
      cd13617
      Location:355 → 693
      PBP2_transferrin_C; The C-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily
      cd13618
      Location:24 → 346
      PBP2_transferrin_N; The N-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q29545.1 GenPept UniProtKB/Swiss-Prot:Q29545

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials