KIT KIT proto-oncogene, receptor tyrosine kinase [Sus scrofa (pig)] - Gene

Summary

Official Symbol: KITprovided by VGNC
Official Full Name: KIT proto-oncogene, receptor tyrosine kinaseprovided by VGNC
Primary source: VGNC:VGNC:98060
See related: Ensembl:ENSSSCG00000008842
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: MGF
Expression: Ubiquitous expression in ovary (RPKM 13.6), spleen (RPKM 9.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	8	NC_010450.4 (41402334..41492306)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	8	NC_010450.3 (43550231..43601377)

Chromosome 8 - NC_010450.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that DDX4 and c-kit are putative markers of undifferentiated spermatogonia in the prepubertal porcine testis.
Title: Stage-specific expression of DDX4 and c-kit at different developmental stages of the porcine testis.
A simple, rapid method, with high specificity and stability, for the detection of the KIT genotype in pigs was established using TaqMan MGB probe real-time quantitative PCR.
Title: Detection of KIT Genotype in Pigs by TaqMan MGB Real-Time Quantitative Polymerase Chain Reaction.
mRNA expression of c-kit and SCF was decreased in gallbladder tissues in the HCD group. Consistent with the findings of RT-PCR, a lower expression level of c-kit and SCF protein was also observed in HCD animals.
Title: The role of interstitial Cajal-like cells in the formation of cholesterol stones in guinea pig gallbladder.
Delayed enrichment for c-kit and inducing cardiac differentiation attenuated protective effects of BMSCs' transplantation in pig model of acute myocardial infarction.
Title: Delayed enrichment for c-kit and inducing cardiac differentiation attenuated protective effects of BMSCs' transplantation in pig model of acute myocardial ischemia.
It appears that the KIT gene would not be a major causal gene for melanoma development in pig, its genetic variation could be influencing this trait. Of 10 coding SNPs, three were non-synonymous mutations, likely to affect the protein conformation.
Title: KIT and melanoma predisposition in pigs: sequence variants and association analysis.
Study analysed KIT gene in several pig breeds and populations with different coat colours and patterns, genotyping a few polymorphisms; the 21 exons and parts of the intronic regions were sequenced in these pigs and 69 polymorphisms were identified.
Title: Genetic heterogeneity and selection signature at the KIT gene in pigs showing different coat colours and patterns.
Pravastatin improves function in hibernating myocardium by mobilizing CD133+ and cKit+ bone marrow progenitor cells and promoting myocytes to reenter the growth phase of the cardiac cell cycle.
Title: Pravastatin improves function in hibernating myocardium by mobilizing CD133+ and cKit+ bone marrow progenitor cells and promoting myocytes to reenter the growth phase of the cardiac cell cycle.
KIT-KL might not be associated with the growth initiation of porcine primordial oocytes, although they do enhance the survival of the oocytes
Title: KIT-KIT ligand in the growth of porcine oocytes in primordial follicles.
The Chinese aboriginal Rongchang white pig does not carry the KIT dominant white allele present in Western white pig breeds.
Title: Chinese white Rongchang pig does not have the dominant white allele of KIT but has the dominant black allele of MC1R.
Variations in the KIT gene are associated with coat color.
Title: Genetic analysis of the KIT and MC1R genes in Chinese indigenous pigs with belt-like coat color phenotypes.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables cytokine binding	IEA Inferred from Electronic Annotation more info	PubMed
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in Fc receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in Kit signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of MAP kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of receptor complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: mast/stem cell growth factor receptor Kit

Names: SCFR; c-kit; proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; tyrosine-protein kinase Kit

NP_001037990.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044525.1 → NP_001037990.1 mast/stem cell growth factor receptor Kit precursor

See identical proteins and their annotated locations for NP_001037990.1

Status: PROVISIONAL

Source sequence(s)

AB250963

UniProtKB/Swiss-Prot

Q2HWD6

UniProtKB/TrEMBL

I3W8V5

Related

ENSSSCP00000009430.3, ENSSSCT00000009679.5

Conserved Domains (7) summary

cd00096
Location:426 → 505

Ig; Immunoglobulin domain

cd05860
Location:311 → 411

Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)

smart00409
Location:426 → 505

IG; Immunoglobulin

smart00410
Location:220 → 307

IG_like; Immunoglobulin like

cd05104
Location:549 → 924

PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit

pfam00047
Location:216 → 305

ig; Immunoglobulin domain

pfam07714
Location:585 → 920

Pkinase_Tyr; Protein tyrosine kinase