GALP galanin like peptide [Sus scrofa (pig)] - Gene

Summary

Official Symbol: GALPprovided by VGNC
Official Full Name: galanin like peptideprovided by VGNC
Primary source: VGNC:VGNC:88338
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Biased expression in liver (RPKM 29.9), mixtures (RPKM 12.1) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	6	NC_010448.4 (60485612..60493591)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	6	NC_010448.3 (55726463..55732573, complement)

Chromosome 6 - NC_010448.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The association analysis with litter size traits showed that at both loci CC and GG genotypes were different for NBA for all parities in DIV pigs (P < 0.05). However, two SNPs were not in significant linkage disequilibrium
Title: Identification of the promoter region and genetic mutations of the porcine GALP gene.
2D-NMR and circular dichroism spectroscopy demonstrate that GALP does not adopt a preferred conformation in pure water alone, but shows characteristics of transient turn-like structures in two distinct regions
Title: Presence of transient helical segments in the galanin-like peptide evident from (1)H NMR, circular dichroism, and prediction studies.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IEA Inferred from Electronic Annotation more info	PubMed
involved_in behavioral response to starvation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in defense response to Gram-negative bacterium	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: galanin-like peptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001348949.1 → NP_001335878.1 galanin-like peptide isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region resulting in a frameshift compared to variant 1. The encoded isoform (2) has a distinct C-terminus compared to isoform 1.

Source sequence(s)

AF188490, AW436648, BP455542, EV956703

UniProtKB/TrEMBL

A0A8D0N0R6, A0A8D0V496, A0A8D1I352

Conserved Domains (1) summary

cl27584
Location:23 → 43

Galanin
NM_213825.2 → NP_998990.1 galanin-like peptide isoform 1 precursor

See identical proteins and their annotated locations for NP_998990.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (1).

Source sequence(s)

AF188490, AW436648, EV956703, FD607412

UniProtKB/Swiss-Prot

Q9TT95

UniProtKB/TrEMBL

A0A4X1T6V8

Conserved Domains (1) summary

pfam01296
Location:31 → 43

Galanin; Galanin