U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    ANGPT2 angiopoietin 2 [ Sus scrofa (pig) ]

    Gene ID: 396730, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    ANGPT2
    Gene description
    angiopoietin 2
    See related
    Ensembl:ENSSSCG00000015753
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    ANG2
    Expression
    Ubiquitous expression in lung (RPKM 1.8), subcutaneous adipose (RPKM 1.7) and 8 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ANGPT2 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 15 NC_010457.5 (37544177..37600925, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 15 NC_010457.4 (42687923..42787653, complement)

    Chromosome 15 - NC_010457.5Genomic Context describing neighboring genes Neighboring gene CUB and Sushi multiple domains 1 Neighboring gene uncharacterized LOC110257101 Neighboring gene U6 snRNA-associated Sm-like protein LSm3 pseudogene Neighboring gene microcephalin 1 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 5 Neighboring gene XK related 5

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Immunohistochemical detection of the angiopoietins during porcine metanephric kidney development. De Spiegelaere W, et al. Acta Histochem, 2011 Sep. PMID 20598355
    2. Immunohistochemical determination of Ang-1, Ang-2 and Tie-2 in placentas of sows at 30, 60 and 114 days of gestation and validation through a bioinformatic approach. Fiorimanti MR, et al. Anim Reprod Sci, 2018 Aug. PMID 29885854
    3. The angiopoietin-tie2 system in coronary artery endothelium prevents oxidized low-density lipoprotein-induced apoptosis. Kim I, et al. Cardiovasc Res, 2001 Mar. PMID 11230987
    4. Expression and localization of angiogenic growth factors in developing porcine mesonephric glomeruli. De Spiegelaere W, et al. J Histochem Cytochem, 2010 Dec. PMID 20713984, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The presence of angiopoietins in the trophoblast suggests a specific role for these pro-angiogenic factors in the tissue formation at the maternal-fetal interface.
      Title: Immunohistochemical determination of Ang-1, Ang-2 and Tie-2 in placentas of sows at 30, 60 and 114 days of gestation and validation through a bioinformatic approach.
    2. expression of angiopoietin 2 in the porcine metanephric kidney was observed in the podocytes of early developing glomeruli, but not in the cells near the glomerular hilus
      Title: Immunohistochemical detection of the angiopoietins during porcine metanephric kidney development.
    3. ANGPT2 remained upregulated during maturation of glomeruli, which may be explained by the continuous growth of the glomeruli, as observed by stereological examination.
      Title: Expression and localization of angiogenic growth factors in developing porcine mesonephric glomeruli.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables receptor tyrosine kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Tie signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    angiopoietin-2
    Names
    ANG-2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213808.1 → NP_998973.1  angiopoietin-2 precursor

      See identical proteins and their annotated locations for NP_998973.1

      Status: PROVISIONAL

      Source sequence(s)
      AF233228
      UniProtKB/Swiss-Prot
      Q9BDY7
      UniProtKB/TrEMBL
      A0A8D0KAF6
      Related
      ENSSSCP00000016694.4, ENSSSCT00000017154.4
      Conserved Domains (2) summary
      smart00186
      Location:281 → 494
      FBG; Fibrinogen-related domains (FReDs)
      cl19219
      Location:138 → 243
      DUF342; Protein of unknown function (DUF342)

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010457.5 Reference Sscrofa11.1 Primary Assembly

      Range
      37544177..37600925 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005671650.3 → XP_005671707.1  angiopoietin-2 isoform X1

      UniProtKB/TrEMBL
      A0A480E303, A0A4X1VXH8, A0A8D0KAF6
      Related
      ENSSSCP00000067734.1, ENSSSCT00000078714.1
      Conserved Domains (2) summary
      smart00186
      Location:280 → 493
      FBG; Fibrinogen-related domains (FReDs)
      cl19219
      Location:138 → 243
      DUF342; Protein of unknown function (DUF342)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BDY7.1 GenPept UniProtKB/Swiss-Prot:Q9BDY7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.