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    BAX BCL2 associated X, apoptosis regulator [ Sus scrofa (pig) ]

    Gene ID: 396633, updated on 15-Jul-2024

    Summary

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    Gene symbol
    BAX
    Gene description
    BCL2 associated X, apoptosis regulator
    See related
    Ensembl:ENSSSCG00000061946
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    BAX-ALPHA
    Expression
    Ubiquitous expression in spleen (RPKM 23.8), ovary (RPKM 20.6) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See BAX in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 6 NC_010448.4 (54222341..54228150)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 6 NC_010448.3 (50100514..50106337, complement)

    Chromosome 6 - NC_010448.4Genomic Context describing neighboring genes Neighboring gene nucleobindin 1 Neighboring gene dihydrodiol dehydrogenase Neighboring gene uncharacterized LOC110261018 Neighboring gene ferritin light chain Neighboring gene glycogen synthase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Joint Analysis of Genome-wide DNA Methylation and Transcription Sequencing Identifies the Role of BAX Gene in Heat Stress-Induced-Sertoli Cells Apoptosis. Hu Y, et al. Reprod Sci, 2024 May. PMID 38180610
    2. Effects of severe hypocapnia on expression of bax and bcl-2 proteins, DNA fragmentation, and membrane peroxidation products in cerebral cortical mitochondria of newborn piglets. Lasso Pirot A, et al. Neonatology, 2007. PMID 17344648
    3. Bid and Bax are involved in granulosa cell apoptosis during follicular atresia in porcine ovaries. Sai T, et al. J Reprod Dev, 2011 Jun. PMID 21441714
    4. Effects of niacin supplementation during in vitro culture on the developmental competence of porcine embryos. Almubarak A, et al. Reprod Domest Anim, 2023 Dec. PMID 37786952
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Joint Analysis of Genome-wide DNA Methylation and Transcription Sequencing Identifies the Role of BAX Gene in Heat Stress-Induced-Sertoli Cells Apoptosis.
      Title: Joint Analysis of Genome-wide DNA Methylation and Transcription Sequencing Identifies the Role of BAX Gene in Heat Stress-Induced-Sertoli Cells Apoptosis.
    2. Bid and Bax are signal transduction factors in granulosa cells and play proapoptotic roles.
      Title: Bid and Bax are involved in granulosa cell apoptosis during follicular atresia in porcine ovaries.
    3. The data demonstrate that severe hypocapnia results in increased Bax expression, DNA fragmentation, and membrane lipid peroxidation in mitochondria of cerebral cortical neurons of newborn piglets, and may result in apoptotic cell death.
      Title: Effects of severe hypocapnia on expression of bax and bcl-2 proteins, DNA fragmentation, and membrane peroxidation products in cerebral cortical mitochondria of newborn piglets.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mitochondrial fusion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in release of cytochrome c from mitochondria IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    apoptosis regulator BAX
    Names
    BCL2-associated X protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010448.4 Reference Sscrofa11.1 Primary Assembly

      Range
      54222341..54228150
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003127290.5 → XP_003127338.2  apoptosis regulator BAX isoform X1

      UniProtKB/TrEMBL
      A0A286ZTT0, A0A4X1W035, A0A4X1W1A2
      Related
      ENSSSCP00000034895.2, ENSSSCT00000063771.2
      Conserved Domains (2) summary
      cd06845
      Location:25 → 164
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
      TIGR00865
      Location:5 → 192
      bcl-2; apoptosis regulator

    2. XM_013998624.2 → XP_013854078.1  apoptosis regulator BAX isoform X2

      UniProtKB/TrEMBL
      Q70AD3
      Conserved Domains (2) summary
      cd06845
      Location:5 → 127
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
      TIGR00865
      Location:1 → 155
      bcl-2; apoptosis regulator
    Nucleotide Protein
    Heading Accession and Version

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