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    NGF nerve growth factor [ Gallus gallus (chicken) ]

    Gene ID: 396466, updated on 10-Oct-2024

    Summary

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    Symbol
    NGFprovided by CGNC
    Full Name
    nerve growth factorprovided by CGNC
    Primary source
    CGNC:1838
    See related
    Ensembl:ENSGALG00010025423
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    NGFB; beta-NGF
    Orthologs
    human mouse all
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    Genomic context

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    See NGF in Genome Data Viewer
    Location:
    chromosome: 26
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 26 NC_052557.1 (4068260..4091234, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 26 NC_052598.1 (4036097..4059075, complement)

    Chromosome 26 - NC_052557.1Genomic Context describing neighboring genes Neighboring gene bile acid receptor-like Neighboring gene synaptonemal complex protein 1 Neighboring gene tetraspanin 2 Neighboring gene thyroid stimulating hormone beta Neighboring gene uncharacterized LOC101747934 Neighboring gene Fanconi anemia complementation group E

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nerve growth factor-induced formation of axonal filopodia and collateral branches involves the intra-axonal synthesis of regulators of the actin-nucleating Arp2/3 complex. Spillane M, et al. J Neurosci, 2012 Dec 5. PMID 23223289, Free PMC Article
    2. Nerve growth factor regulates axial rotation during early stages of chick embryo development. Manca A, et al. Proc Natl Acad Sci U S A, 2012 Feb 7. PMID 22308471, Free PMC Article
    3. Alternative usage of 5' exons in the chicken nerve growth factor gene: refined characterization of a weakly expressed gene. Bertaux O, et al. Gene, 2004 Jun 9. PMID 15256258
    4. Molecular cloning of the avian beta-nerve growth factor gene: transcription in brain. Wion D, et al. FEBS Lett, 1986 Jul 14. PMID 3720959
    5. Structure and expression of the chicken beta nerve growth factor gene. Ebendal T, et al. EMBO J, 1986 Jul. PMID 3017695, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results suggest that NGF differentially affects the phosphorylation of MAP1B within the main axon shaft and the laterally projecting filopodia
      Title: Nerve growth factor promotes reorganization of the axonal microtubule array at sites of axon collateral branching.
    2. NGF promotes sensory axon branching through regulation of the actin cytoskeleton using both canonical signaling mechanisms and intra-axonal protein synthesis downstream of PI3K signaling.
      Title: Nerve growth factor-induced formation of axonal filopodia and collateral branches involves the intra-axonal synthesis of regulators of the actin-nucleating Arp2/3 complex.
    3. These results reveal a role for NGF in early chicken embryo development.
      Title: Nerve growth factor regulates axial rotation during early stages of chick embryo development.
    4. Levels of NGF, BDNF and NT-3 were all up regulated from E7 to E14 in the spinal cord of embryonic chicken during development.
      Title: [The expression level of NGF, BDNF and NT-3 in spinal cord of growing embryonic chicken].
    5. Data show that endogenous NGF induces DNA replication in a subpopulation of differentiating retinal ganglion cells that express both the neurotrophin receptor p75 and the E2F1 transcription factor, but that lack the retinoblastoma protein.
      Title: Somatic tetraploidy in specific chick retinal ganglion cells induced by nerve growth factor.
    6. Transcripts of exon 1b are expressed in most tissues tested, whereas exon 1a are mainly in heart and reproductive organs and exon 1c are in peripheral organs other than heart.
      Title: Alternative usage of 5' exons in the chicken nerve growth factor gene: refined characterization of a weakly expressed gene.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nerve growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in memory IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nerve development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nerve growth factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neuron projection morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of collateral sprouting IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    beta-nerve growth factor
    Names
    nerve growth factor (beta polypeptide)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293108.1 → NP_001280037.1  beta-nerve growth factor precursor

      See identical proteins and their annotated locations for NP_001280037.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BU313448, BU337330, CD217960
      UniProtKB/Swiss-Prot
      P05200
      UniProtKB/TrEMBL
      A0A140T8F7
      Related
      ENSGALP00010038375.1, ENSGALT00010062094.1
      Conserved Domains (1) summary
      pfam00243
      Location:128 → 236
      NGF; Nerve growth factor family

    2. NM_001293109.2 → NP_001280038.1  beta-nerve growth factor precursor

      See identical proteins and their annotated locations for NP_001280038.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      JAENSK010000356
      UniProtKB/Swiss-Prot
      P05200
      UniProtKB/TrEMBL
      A0A140T8F7
      Related
      ENSGALP00010038353.1, ENSGALT00010062072.1
      Conserved Domains (1) summary
      pfam00243
      Location:128 → 236
      NGF; Nerve growth factor family

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052557.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      4068260..4091234 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015298897.4 → XP_015154383.1  beta-nerve growth factor isoform X1

      UniProtKB/Swiss-Prot
      P05200
      UniProtKB/TrEMBL
      A0A140T8F7
      Conserved Domains (1) summary
      pfam00243
      Location:128 → 236
      NGF; Nerve growth factor family

    2. XM_046904106.1 → XP_046760062.1  beta-nerve growth factor isoform X1

      UniProtKB/TrEMBL
      A0A140T8F7
      Related
      ENSGALP00010038369.1, ENSGALT00010062088.1

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052598.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      4036097..4059075 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046932898.1 → XP_046788854.1  beta-nerve growth factor isoform X1

      UniProtKB/TrEMBL
      A0A140T8F7

    2. XM_046932897.1 → XP_046788853.1  beta-nerve growth factor isoform X1

      UniProtKB/TrEMBL
      A0A140T8F7
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05200.1 GenPept UniProtKB/Swiss-Prot:P05200

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials