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    PKLR pyruvate kinase, liver and RBC [ Gallus gallus (chicken) ]

    Gene ID: 396456, updated on 10-Oct-2024

    Summary

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    Symbol
    PKLRprovided by CGNC
    Full Name
    pyruvate kinase, liver and RBCprovided by CGNC
    Primary source
    CGNC:1412
    See related
    Ensembl:ENSGALG00010021110
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    PKM; PKM2
    Orthologs
    human mouse all
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    Genomic context

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    See PKLR in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 10 NC_052541.1 (1607490..1624773, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 10 NC_052582.1 (1481253..1500490, complement)

    Chromosome 10 - NC_052541.1Genomic Context describing neighboring genes Neighboring gene myosin IXA Neighboring gene SUMO/sentrin peptidase family member, NEDD8 specific Neighboring gene GRAM domain containing 2 Neighboring gene microRNA 6660 Neighboring gene poly(ADP-ribose) polymerase family member 6 Neighboring gene CUGBP Elav-like family member 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Primary structure of chicken muscle pyruvate kinase mRNA. Lonberg N, et al. Proc Natl Acad Sci U S A, 1983 Jun. PMID 6574503, Free PMC Article
    2. Intron/exon structure of the chicken pyruvate kinase gene. Lonberg N, et al. Cell, 1985 Jan. PMID 2981634
    3. Proteomic studies of Syk-interacting proteins using a novel amine-specific isotope tag and GFP nanotrap. Galan JA, et al. J Am Soc Mass Spectrom, 2011 Feb. PMID 21472591, Free PMC Article
    4. Conserved BK channel-protein interactions reveal signals relevant to cell death and survival. Sokolowski B, et al. PLoS One, 2011. PMID 22174833, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables potassium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables pyruvate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to insulin stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pyruvate kinase PKM
    Names
    pyruvate kinase M1/2
    pyruvate kinase muscle isozyme
    pyruvate kinase, muscle
    NP_990800.1
    XP_015134281.1
    XP_015134282.1
    XP_025009576.1
    XP_046754900.1
    XP_046754901.1
    XP_046780567.1
    XP_046780568.1
    XP_046780569.1
    XP_046780570.1
    XP_046780571.1
    XP_046780572.1
    XP_046780573.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205469.2 → NP_990800.1  pyruvate kinase PKM

      See identical proteins and their annotated locations for NP_990800.1

      Status: PROVISIONAL

      Source sequence(s)
      JAENSK010000245
      UniProtKB/Swiss-Prot
      P00548
      Related
      ENSGALP00010030307.1, ENSGALT00010051116.1
      Conserved Domains (2) summary
      cd00288
      Location:41 → 529
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
      TIGR01064
      Location:42 → 526
      pyruv_kin; pyruvate kinase

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052541.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      1607490..1624773 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015278795.4 → XP_015134281.1  pyruvate kinase PKM isoform X3

      UniProtKB/TrEMBL
      F1NW43
      Related
      ENSGALP00010030300.1, ENSGALT00010051109.1
      Conserved Domains (1) summary
      cd00288
      Location:41 → 529
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...

    2. XM_025153808.3 → XP_025009576.1  pyruvate kinase PKM isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZG91
      Related
      ENSGALP00010030297.1, ENSGALT00010051106.1
      Conserved Domains (1) summary
      cd00288
      Location:61 → 549
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...

    3. XM_015278796.4 → XP_015134282.1  pyruvate kinase PKM isoform X1

      Conserved Domains (2) summary
      cd00288
      Location:61 → 549
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
      TIGR01064
      Location:62 → 546
      pyruv_kin; pyruvate kinase

    4. XM_046898945.1 → XP_046754901.1  pyruvate kinase PKM isoform X1

    5. XM_046898944.1 → XP_046754900.1  pyruvate kinase PKM isoform X1

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052582.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      1481253..1500490 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046924612.1 → XP_046780568.1  pyruvate kinase PKM isoform X5

    2. XM_046924611.1 → XP_046780567.1  pyruvate kinase PKM isoform X4

      UniProtKB/TrEMBL
      A0A8V0ZGA1

    3. XM_046924617.1 → XP_046780573.1  pyruvate kinase PKM isoform X3

      UniProtKB/TrEMBL
      F1NW43

    4. XM_046924614.1 → XP_046780570.1  pyruvate kinase PKM isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZG91

    5. XM_046924613.1 → XP_046780569.1  pyruvate kinase PKM isoform X1

    6. XM_046924616.1 → XP_046780572.1  pyruvate kinase PKM isoform X1

    7. XM_046924615.1 → XP_046780571.1  pyruvate kinase PKM isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00548.2 GenPept UniProtKB/Swiss-Prot:P00548

    Gene LinkOut

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