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    TNNT2 troponin T2, cardiac type [ Gallus gallus (chicken) ]

    Gene ID: 396433, updated on 10-Oct-2024

    Summary

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    Symbol
    TNNT2provided by CGNC
    Full Name
    troponin T2, cardiac typeprovided by CGNC
    Primary source
    CGNC:176
    See related
    Ensembl:ENSGALG00010026743
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See TNNT2 in Genome Data Viewer
    Location:
    chromosome: 26
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 26 NC_052557.1 (842445..853745)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 26 NC_052598.1 (811840..823210)

    Chromosome 26 - NC_052557.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121107605 Neighboring gene troponin I type 1 (skeletal, slow) Neighboring gene ladinin 1 Neighboring gene plakophilin 1 Neighboring gene immunoglobulin-like and fibronectin type III domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cardiac troponin T is necessary for normal development in the embryonic chick heart. England J, et al. J Anat, 2016 Sep. PMID 27194630, Free PMC Article
    2. Binding of calcium ions to an avian flight muscle troponin T. Zhang Z, et al. Biochemistry, 2004 Mar 9. PMID 14992602
    3. A single troponin T gene regulated by different programs in cardiac and skeletal muscle development. Cooper TA, et al. Science, 1984 Nov 23. PMID 6095446
    4. A single cardiac troponin T gene generates embryonic and adult isoforms via developmentally regulated alternate splicing. Cooper TA, et al. J Biol Chem, 1985 Sep 15. PMID 2993302
    5. Contractile regulatory proteins tropomyosin and troponin-T as indicators of the modulatory role of retinoic acid. Vélez C, et al. Cells Tissues Organs, 2003. PMID 14605492

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. this is the first study associating TNNT2 to abnormal atrial septal growth, reduced ventricular trabeculation and ventricular diverticula
      Title: Cardiac troponin T is necessary for normal development in the embryonic chick heart.
    2. Correlation of molecular and functional effects of mutations in cardiac troponin T linked to familial hypertrophic cardiomyopathy
      Title: Correlation of molecular and functional effects of mutations in cardiac troponin T linked to familial hypertrophic cardiomyopathy: an integrative in silico/in vitro approach.
    3. This study found that tissue hypoxia is likely a normal component of embryonic development in the chicken based on the upregulation of hypoxia response genes.
      Title: The expression patterns of hypoxia-inducing factor subunit alpha-1, heme oxygenase, hypoxia upregulated protein 1, and cardiac troponin T during development of the chicken heart.
    4. In cultures treated for 48 h with retinoids, the levels of alpha-tropomyosin and troponin-T showed significant increases in the cytoplasmic compartment of cardiac myocytes
      Title: Contractile regulatory proteins tropomyosin and troponin-T as indicators of the modulatory role of retinoic acid.
    5. The glutamate-rich N-terminal region of chicken breast muscle TnT binds to calcium and may play a role in modulating the calcium-mediated regulatory process of striated muscle contraction.
      Title: Binding of calcium ions to an avian flight muscle troponin T.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables tropomyosin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables troponin C binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables troponin I binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cardiac muscle contraction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of muscle contraction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sarcomere organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of troponin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    troponin T, cardiac muscle isoforms
    Names
    cardiac troponin T form I
    tnTC
    troponin T type 2 (cardiac)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205449.2 → NP_990780.2  troponin T, cardiac muscle isoforms

      Status: PROVISIONAL

      Source sequence(s)
      JAENSK010000356
      UniProtKB/Swiss-Prot
      P02642
      Conserved Domains (1) summary
      PTZ00266
      Location:96 → 165
      PTZ00266; NIMA-related protein kinase; Provisional

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052557.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      842445..853745
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015298700.4 → XP_015154186.2  troponin T, cardiac muscle isoforms isoform X2

      UniProtKB/Swiss-Prot
      P02642
      Related
      ENSGALP00010039665.1, ENSGALT00010064923.1
      Conserved Domains (1) summary
      PTZ00266
      Location:96 → 165
      PTZ00266; NIMA-related protein kinase; Provisional

    2. XM_015298697.4 → XP_015154183.2  troponin T, cardiac muscle isoforms isoform X1

      UniProtKB/Swiss-Prot
      P02642
      Conserved Domains (1) summary
      PTZ00266
      Location:96 → 165
      PTZ00266; NIMA-related protein kinase; Provisional

    3. XM_040652692.2 → XP_040508626.1  troponin T, cardiac muscle isoforms isoform X3

      UniProtKB/TrEMBL
      A0A8V1A8V8
      Related
      ENSGALP00010039653.1, ENSGALT00010064897.1
      Conserved Domains (1) summary
      pfam00992
      Location:97 → 232
      Troponin

    4. XM_015298699.4 → XP_015154185.2  troponin T, cardiac muscle isoforms isoform X2

      UniProtKB/Swiss-Prot
      P02642
      Related
      ENSGALP00010039658.1, ENSGALT00010064904.1
      Conserved Domains (1) summary
      PTZ00266
      Location:96 → 165
      PTZ00266; NIMA-related protein kinase; Provisional

    5. XM_015298702.4 → XP_015154188.1  troponin T, cardiac muscle isoforms isoform X3

      UniProtKB/TrEMBL
      A0A8V1A8V8
      Related
      ENSGALP00010039664.1, ENSGALT00010064917.1
      Conserved Domains (1) summary
      pfam00992
      Location:97 → 232
      Troponin

    6. XM_040652693.2 → XP_040508627.1  troponin T, cardiac muscle isoforms isoform X4

      UniProtKB/TrEMBL
      A0A8V1A8V8
      Related
      ENSGALP00010039662.1, ENSGALT00010064912.1
      Conserved Domains (1) summary
      PTZ00266
      Location:86 → 155
      PTZ00266; NIMA-related protein kinase; Provisional

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052598.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      811840..823210
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046932893.1 → XP_046788849.1  troponin T, cardiac muscle isoforms isoform X2

    2. XM_046932890.1 → XP_046788846.1  troponin T, cardiac muscle isoforms isoform X1

    3. XM_046932895.1 → XP_046788851.1  troponin T, cardiac muscle isoforms isoform X3

    4. XM_046932892.1 → XP_046788848.1  troponin T, cardiac muscle isoforms isoform X2

    5. XM_046932891.1 → XP_046788847.1  troponin T, cardiac muscle isoforms isoform X5

    6. XM_046932894.1 → XP_046788850.1  troponin T, cardiac muscle isoforms isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P02642.2 GenPept UniProtKB/Swiss-Prot:P02642

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials