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    TTR transthyretin [ Gallus gallus (chicken) ]

    Gene ID: 396277, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TTRprovided by CGNC
    Official Full Name
    transthyretinprovided by CGNC
    Primary source
    CGNC:49731
    See related
    Ensembl:ENSGALG00010006069
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See TTR in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (105791008..105800067)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (105860150..105869209)

    Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene desmoglein 4 Neighboring gene uncharacterized LOC107052701 Neighboring gene desmoglein 2 Neighboring gene transthyretin-like Neighboring gene beta-1,4-galactosyltransferase 6 Neighboring gene opsin 5-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The affinity of transthyretin for T(3) or T(4) does not determine which form of the hormone accumulates in the choroid plexus. Richardson SJ, et al. Gen Comp Endocrinol, 2018 Aug 1. PMID 28919452
    2. Photostimulated expression of type 2 iodothyronine deiodinase mRNA is greatly attenuated in the rostral tuberal hypothalamus of the photorefractory turkey hen. Steinman MQ, et al. J Neuroendocrinol, 2008 Nov. PMID 18752654
    3. Interaction of diethylstilbestrol and ioxynil with transthyretin in chicken serum. Eguchi R, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2008 Apr. PMID 18243807
    4. The crystal structure of transthyretin from chicken. Sunde M, et al. Eur J Biochem, 1996 Mar 1. PMID 8612621
    5. Isolation, characterization, cDNA cloning and gene expression of an avian transthyretin. Implications for the evolution of structure and function of transthyretin in vertebrates. Duan W, et al. Eur J Biochem, 1991 Sep 15. PMID 1833190

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TTR, Deiodinase 3 and OATP1C1 expression were found to be highly concentrated in the choroid plexus.
      Title: The affinity of transthyretin for T(3) or T(4) does not determine which form of the hormone accumulates in the choroid plexus.
    2. Difference in triiodophenol(TIP) binding between female and male chickens; females bind less TIP than male adult and juvenile chickens.
      Title: Characterization of plasma triiodophenol binding proteins in vertebrates and tissue distribution of triiodophenol in Rana catesbeiana tadpoles.
    3. Significant amount of diethylstilbestrol and ioxynil interacted with TTR in whole chicken serum.
      Title: Interaction of diethylstilbestrol and ioxynil with transthyretin in chicken serum.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables thyroid hormone binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in purine nucleobase metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transthyretin
    Names
    TBPA
    prealbumin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001281498.1 → NP_001268427.1  transthyretin isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting protein (isoform 2) has a longer N-terminus compared to isoform 1.
      Source sequence(s)
      BU119521, BU352734, CR407350
      UniProtKB/TrEMBL
      A0A1I7Q422, A0A8V0XRG8
      Related
      ENSGALP00010008537.1, ENSGALT00010014520.1
      Conserved Domains (1) summary
      smart00095
      Location:48 → 168
      TR_THY; Transthyretin

    2. NM_205335.3 → NP_990666.1  transthyretin isoform 1 precursor

      See identical proteins and their annotated locations for NP_990666.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter protein (isoform 1).
      Source sequence(s)
      BU269372, BU339400, BU352734, DN851840, X60471
      UniProtKB/Swiss-Prot
      P27731
      UniProtKB/TrEMBL
      A0A8V0XRG8
      Related
      ENSGALP00010008532.1, ENSGALT00010014515.1
      Conserved Domains (1) summary
      smart00095
      Location:30 → 150
      TR_THY; Transthyretin

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      105791008..105800067
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      105860150..105869209
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27731.1 GenPept UniProtKB/Swiss-Prot:P27731

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.