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    NFE2L2 nuclear factor, erythroid 2 like 2 [ Gallus gallus (chicken) ]

    Gene ID: 396014, updated on 10-Oct-2024

    Summary

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    Symbol
    NFE2L2provided by CGNC
    Full Name
    nuclear factor, erythroid 2 like 2provided by CGNC
    Primary source
    CGNC:49604
    See related
    Ensembl:ENSGALG00010024107
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    ECH; NRF2
    Orthologs
    human mouse all
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    Genomic context

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    See NFE2L2 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 7 NC_052538.1 (15417979..15442325)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 7 NC_052579.1 (15335657..15359980)

    Chromosome 7 - NC_052538.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121113382 Neighboring gene intraflagellar transport 70A Neighboring gene alkylglycerone phosphate synthase Neighboring gene heterogeneous nuclear ribonucleoprotein A3 Neighboring gene uncharacterized LOC107053812 Neighboring gene metaxin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HgCl2 exposure mediates pyroptosis of HD11 cells and promotes M1 polarization and the release of inflammatory factors through ROS/Nrf2/NLRP3.
      Title: HgCl(2) exposure mediates pyroptosis of HD11 cells and promotes M1 polarization and the release of inflammatory factors through ROS/Nrf2/NLRP3.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclear factor erythroid 2-related factor 2
    Names
    NF-E2-related factor 2
    nuclear factor (erythroid-derived 2)-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001396902.1 → NP_001383831.1  nuclear factor erythroid 2-related factor 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000236
      UniProtKB/TrEMBL
      A0A8V1A3A2, Q90834
      Conserved Domains (1) summary
      cd14720
      Location:472 → 539
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain

    2. NM_001396903.1 → NP_001383832.1  nuclear factor erythroid 2-related factor 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000236
      UniProtKB/TrEMBL
      A0A8V1A3A2, Q90834
      Related
      ENSGALP00010035740.1, ENSGALT00010058774.1
      Conserved Domains (1) summary
      cd14720
      Location:472 → 539
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain

    3. NM_001396904.1 → NP_001383833.1  nuclear factor erythroid 2-related factor 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000236
      UniProtKB/TrEMBL
      A0A8V1A3A2, Q90834
      Conserved Domains (1) summary
      cd14720
      Location:472 → 539
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain

    4. NM_001396905.1 → NP_001383834.1  nuclear factor erythroid 2-related factor 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000236
      UniProtKB/TrEMBL
      A0A8V0ZQQ1, A0A8V1A3A2
      Related
      ENSGALP00010035764.1, ENSGALT00010058799.1
      Conserved Domains (1) summary
      cd14720
      Location:483 → 550
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain

    5. NM_205117.2 → NP_990448.1  nuclear factor erythroid 2-related factor 2 isoform 1

      See identical proteins and their annotated locations for NP_990448.1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000236
      UniProtKB/TrEMBL
      A0A8V1A3A2, Q90834
      Related
      ENSGALP00010035756.1, ENSGALT00010058791.1
      Conserved Domains (1) summary
      cd14720
      Location:472 → 539
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052538.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      15417979..15442325
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046943472.1 → XP_046799428.1  nuclear factor erythroid 2-related factor 2 isoform X3

      UniProtKB/TrEMBL
      Q90834

    2. XM_025152146.3 → XP_025007914.2  nuclear factor erythroid 2-related factor 2 isoform X3

      UniProtKB/TrEMBL
      A0A8V1A3A2, Q90834
      Conserved Domains (1) summary
      cd14720
      Location:472 → 539
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain

    3. XM_046943487.1 → XP_046799443.1  nuclear factor erythroid 2-related factor 2 isoform X3

      UniProtKB/TrEMBL
      Q90834

    4. XM_046943482.1 → XP_046799438.1  nuclear factor erythroid 2-related factor 2 isoform X3

      UniProtKB/TrEMBL
      Q90834

    5. XM_046943481.1 → XP_046799437.1  nuclear factor erythroid 2-related factor 2 isoform X3

      UniProtKB/TrEMBL
      Q90834

    6. XM_046943470.1 → XP_046799426.1  nuclear factor erythroid 2-related factor 2 isoform X2

      UniProtKB/TrEMBL
      A0A8V1A3B9
      Related
      ENSGALP00010035760.1, ENSGALT00010058795.1

    7. XM_046943475.1 → XP_046799431.1  nuclear factor erythroid 2-related factor 2 isoform X3

      UniProtKB/TrEMBL
      Q90834

    8. XM_046943490.1 → XP_046799446.1  nuclear factor erythroid 2-related factor 2 isoform X3

      UniProtKB/TrEMBL
      Q90834

    9. XM_046943488.1 → XP_046799444.1  nuclear factor erythroid 2-related factor 2 isoform X3

      UniProtKB/TrEMBL
      Q90834

    10. XM_046943477.1 → XP_046799433.1  nuclear factor erythroid 2-related factor 2 isoform X3

      UniProtKB/TrEMBL
      Q90834

    11. XM_046943478.1 → XP_046799434.1  nuclear factor erythroid 2-related factor 2 isoform X3

      UniProtKB/TrEMBL
      Q90834

    12. XM_046943469.1 → XP_046799425.1  nuclear factor erythroid 2-related factor 2 isoform X2

      UniProtKB/TrEMBL
      A0A8V1A3B9

    13. XM_046943476.1 → XP_046799432.1  nuclear factor erythroid 2-related factor 2 isoform X3

      UniProtKB/TrEMBL
      Q90834

    14. XM_046943484.1 → XP_046799440.1  nuclear factor erythroid 2-related factor 2 isoform X3

      UniProtKB/TrEMBL
      Q90834

    15. XM_046943474.1 → XP_046799430.1  nuclear factor erythroid 2-related factor 2 isoform X3

      UniProtKB/TrEMBL
      Q90834

    16. XM_046943486.1 → XP_046799442.1  nuclear factor erythroid 2-related factor 2 isoform X3

      UniProtKB/TrEMBL
      Q90834

    17. XM_046943480.1 → XP_046799436.1  nuclear factor erythroid 2-related factor 2 isoform X3

      UniProtKB/TrEMBL
      Q90834

    18. XM_046943479.1 → XP_046799435.1  nuclear factor erythroid 2-related factor 2 isoform X3

      UniProtKB/TrEMBL
      Q90834

    19. XM_040703359.2 → XP_040559293.1  nuclear factor erythroid 2-related factor 2 isoform X3

      UniProtKB/TrEMBL
      A0A8V1A3A2, Q90834
      Conserved Domains (1) summary
      cd14720
      Location:472 → 539
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain

    20. XM_046943468.1 → XP_046799424.1  nuclear factor erythroid 2-related factor 2 isoform X1

    21. XM_046943473.1 → XP_046799429.1  nuclear factor erythroid 2-related factor 2 isoform X3

      UniProtKB/TrEMBL
      Q90834

    22. XM_025152148.3 → XP_025007916.2  nuclear factor erythroid 2-related factor 2 isoform X3

      UniProtKB/TrEMBL
      A0A8V1A3A2, Q90834
      Conserved Domains (1) summary
      cd14720
      Location:472 → 539
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain

    23. XM_046943483.1 → XP_046799439.1  nuclear factor erythroid 2-related factor 2 isoform X3

      UniProtKB/TrEMBL
      Q90834

    24. XM_046943471.1 → XP_046799427.1  nuclear factor erythroid 2-related factor 2 isoform X3

      UniProtKB/TrEMBL
      Q90834

    25. XM_040703357.2 → XP_040559291.1  nuclear factor erythroid 2-related factor 2 isoform X3

      UniProtKB/TrEMBL
      A0A8V1A3A2, Q90834
      Conserved Domains (1) summary
      cd14720
      Location:472 → 539
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain

    26. XM_046943489.1 → XP_046799445.1  nuclear factor erythroid 2-related factor 2 isoform X3

      UniProtKB/TrEMBL
      Q90834

    27. XM_046943485.1 → XP_046799441.1  nuclear factor erythroid 2-related factor 2 isoform X3

      UniProtKB/TrEMBL
      Q90834

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052579.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      15335657..15359980
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046921110.1 → XP_046777066.1  nuclear factor erythroid 2-related factor 2 isoform X3

    2. XM_046921121.1 → XP_046777077.1  nuclear factor erythroid 2-related factor 2 isoform X3

    3. XM_046921106.1 → XP_046777062.1  nuclear factor erythroid 2-related factor 2 isoform X3

    4. XM_046921127.1 → XP_046777083.1  nuclear factor erythroid 2-related factor 2 isoform X3

    5. XM_046921120.1 → XP_046777076.1  nuclear factor erythroid 2-related factor 2 isoform X3

    6. XM_046921119.1 → XP_046777075.1  nuclear factor erythroid 2-related factor 2 isoform X3

    7. XM_046921105.1 → XP_046777061.1  nuclear factor erythroid 2-related factor 2 isoform X2

    8. XM_046921113.1 → XP_046777069.1  nuclear factor erythroid 2-related factor 2 isoform X3

    9. XM_046921130.1 → XP_046777086.1  nuclear factor erythroid 2-related factor 2 isoform X3

    10. XM_046921128.1 → XP_046777084.1  nuclear factor erythroid 2-related factor 2 isoform X3

    11. XM_046921115.1 → XP_046777071.1  nuclear factor erythroid 2-related factor 2 isoform X3

    12. XM_046921116.1 → XP_046777072.1  nuclear factor erythroid 2-related factor 2 isoform X3

    13. XM_046921104.1 → XP_046777060.1  nuclear factor erythroid 2-related factor 2 isoform X2

    14. XM_046921114.1 → XP_046777070.1  nuclear factor erythroid 2-related factor 2 isoform X3

    15. XM_046921124.1 → XP_046777080.1  nuclear factor erythroid 2-related factor 2 isoform X3

    16. XM_046921112.1 → XP_046777068.1  nuclear factor erythroid 2-related factor 2 isoform X3

    17. XM_046921126.1 → XP_046777082.1  nuclear factor erythroid 2-related factor 2 isoform X3

    18. XM_046921118.1 → XP_046777074.1  nuclear factor erythroid 2-related factor 2 isoform X3

    19. XM_046921117.1 → XP_046777073.1  nuclear factor erythroid 2-related factor 2 isoform X3

    20. XM_046921123.1 → XP_046777079.1  nuclear factor erythroid 2-related factor 2 isoform X3

    21. XM_046921103.1 → XP_046777059.1  nuclear factor erythroid 2-related factor 2 isoform X1

    22. XM_046921111.1 → XP_046777067.1  nuclear factor erythroid 2-related factor 2 isoform X3

    23. XM_046921108.1 → XP_046777064.1  nuclear factor erythroid 2-related factor 2 isoform X3

    24. XM_046921122.1 → XP_046777078.1  nuclear factor erythroid 2-related factor 2 isoform X3

    25. XM_046921109.1 → XP_046777065.1  nuclear factor erythroid 2-related factor 2 isoform X3

    26. XM_046921107.1 → XP_046777063.1  nuclear factor erythroid 2-related factor 2 isoform X3

    27. XM_046921129.1 → XP_046777085.1  nuclear factor erythroid 2-related factor 2 isoform X3

    28. XM_046921125.1 → XP_046777081.1  nuclear factor erythroid 2-related factor 2 isoform X3

    Nucleotide Protein
    Heading Accession and Version

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