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    TSHB thyroid stimulating hormone beta [ Gallus gallus (chicken) ]

    Gene ID: 395937, updated on 10-Oct-2024

    Summary

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    Symbol
    TSHBprovided by CGNC
    Full Name
    thyroid stimulating hormone betaprovided by CGNC
    Primary source
    CGNC:1832
    See related
    Ensembl:ENSGALG00010025394
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    TSH-B
    Orthologs
    human mouse all
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    Genomic context

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    See TSHB in Genome Data Viewer
    Location:
    chromosome: 26
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 26 NC_052557.1 (4016750..4023301)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 26 NC_052598.1 (3984541..3991082)

    Chromosome 26 - NC_052557.1Genomic Context describing neighboring genes Neighboring gene translation initiation factor IF-2-like Neighboring gene suppressor of IKBKE 1 Neighboring gene bile acid receptor-like Neighboring gene synaptonemal complex protein 1 Neighboring gene tetraspanin 2 Neighboring gene nerve growth factor Neighboring gene uncharacterized LOC101747934

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Diurnal and photoperiodic changes in thyrotrophin-stimulating hormone β expression and associated regulation of deiodinase enzymes (DIO2, DIO3) in the female juvenile chicken hypothalamus. Dunn IC, et al. J Neuroendocrinol, 2017 Dec. PMID 29117457, Free PMC Article
    2. Development of thyroid-stimulating hormone beta subunit-producing cells in the chicken embryonic pituitary gland. Nakamura K, et al. Cells Tissues Organs, 2004. PMID 15237192
    3. Complementary DNA sequence of chicken thyroid-stimulating hormone (TSH) beta subunit. Kato Y, et al. Endocr J, 1998 Aug. PMID 9881912
    4. Cloning and sequence analysis of a cDNA for the beta subunit of chicken thyroid-stimulating hormone. Gregory CC, et al. Gen Comp Endocrinol, 1997 Aug. PMID 9245526
    5. Glucagon-like peptide (GCGL) is a novel potential TSH-releasing factor (TRF) in Chickens: I) Evidence for its potent and specific action on stimulating TSH mRNA expression and secretion in the pituitary. Huang G, et al. Endocrinology, 2014 Nov. PMID 25076122

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Thyrotrophin-stimulating hormone beta expression changes in a dynamic fashion both diurnally and in response to photoperiod.
      Title: Diurnal and photoperiodic changes in thyrotrophin-stimulating hormone β expression and associated regulation of deiodinase enzymes (DIO2, DIO3) in the female juvenile chicken hypothalamus.
    2. Hypothalamic GCGL is most likely to be a novel TSH-releasing factor functioning in chickens, controlling the temporal expression of TSHb in the pituitary.
      Title: Glucagon-like peptide (GCGL) is a novel potential TSH-releasing factor (TRF) in Chickens: I) Evidence for its potent and specific action on stimulating TSH mRNA expression and secretion in the pituitary.
    3. the expression of chicken TSHbeta mRNA starts on E9, TSHbeta-ip cells appear on E10, mainly in the cephalic lobe, and TSHbeta-ip cells can be classified into two cell types
      Title: Development of thyroid-stimulating hormone beta subunit-producing cells in the chicken embryonic pituitary gland.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    thyrotropin subunit beta
    Names
    TSH-beta
    thyroid-stimulating hormone beta subunit
    thyroid-stimulating hormone subunit beta
    thyroptin beta subunit
    thyrotropin beta chain
    thyrotropin beta subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205063.4 → NP_990394.1  thyrotropin subunit beta precursor

      See identical proteins and their annotated locations for NP_990394.1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000356
      UniProtKB/Swiss-Prot
      O57340
      UniProtKB/TrEMBL
      A5YW28, Q7T051
      Related
      ENSGALP00010038296.1, ENSGALT00010062007.1
      Conserved Domains (1) summary
      smart00068
      Location:20 → 126
      GHB; Glycoprotein hormone beta chain homologues

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052557.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      4016750..4023301
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_025143670.3 → XP_024999438.1  thyrotropin subunit beta isoform X1

      UniProtKB/Swiss-Prot
      O57340
      UniProtKB/TrEMBL
      A5YW28, Q7T051
      Conserved Domains (1) summary
      smart00068
      Location:20 → 126
      GHB; Glycoprotein hormone beta chain homologues

    2. XM_046904102.1 → XP_046760058.1  thyrotropin subunit beta isoform X1

      UniProtKB/Swiss-Prot
      O57340
      UniProtKB/TrEMBL
      A5YW28

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052598.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      3984541..3991082
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046932884.1 → XP_046788840.1  thyrotropin subunit beta isoform X1

      UniProtKB/Swiss-Prot
      O57340
      UniProtKB/TrEMBL
      A5YW28

    2. XM_046932883.1 → XP_046788839.1  thyrotropin subunit beta isoform X1

      UniProtKB/Swiss-Prot
      O57340
      UniProtKB/TrEMBL
      A5YW28
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O57340.1 GenPept UniProtKB/Swiss-Prot:O57340

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.