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    CASP2 caspase 2 [ Gallus gallus (chicken) ]

    Gene ID: 395857, updated on 17-Aug-2024

    Summary

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    Symbol
    CASP2provided by CGNC
    Full Name
    caspase 2provided by CGNC
    Primary source
    CGNC:10898
    See related
    Ensembl:ENSGALG00010024068
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    ICH1; CASP-2; ICH1L1S; ICH-1L/1S
    Orthologs
    human mouse all
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    Genomic context

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    See CASP2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (77619616..77645620, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (77820249..77846248, complement)

    Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107054541 Neighboring gene family with sequence similarity 131 member B Neighboring gene uncharacterized LOC124417615 Neighboring gene chloride voltage-gated channel 1 Neighboring gene RAP1 GTPase activating protein 3 Neighboring gene transmembrane protein 139 Neighboring gene glutathione S-transferase kappa 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caspase-dependent cytochrome c release and cell death in chick cardiomyocytes after simulated ischemia-reperfusion. Qin Y, et al. Am J Physiol Heart Circ Physiol, 2004 Jun. PMID 14975933
    2. Characterization of the avian Ich-1 cDNA and expression of Ich-1L mRNA in the hen ovary. Johnson AL, et al. Gene, 1997 Jun 19. PMID 9224894
    3. Non-coding RNAs revealed during identification of genes involved in chicken immune responses. Ahanda ML, et al. Immunogenetics, 2009 Jan. PMID 19009289
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. active caspase-2 initiates cytochrome c release after reperfusion and that it is critical for myocardial ischemia reperfusion-induced apoptosis
      Title: Caspase-dependent cytochrome c release and cell death in chick cardiomyocytes after simulated ischemia-reperfusion.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity involved in execution phase of apoptosis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    caspase-2
    Names
    ICH1 protease
    caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2)
    caspase 2, apoptosis-related cysteine protease
    cysteine protease caspase-2
    protease ICH-1
    NP_001161173.2
    XP_015148709.2
    XP_046762690.1
    XP_046762691.1
    XP_046765357.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167701.2 → NP_001161173.2  caspase-2

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000015
      UniProtKB/Swiss-Prot
      Q98943
      Conserved Domains (2) summary
      cd00032
      Location:162 → 417
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08332
      Location:7 → 93
      CARD_CASP2; Caspase activation and recruitment domain of Caspase-2

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      77619616..77645620 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046909401.1 → XP_046765357.1  caspase-2 isoform X1

      UniProtKB/Swiss-Prot
      Q98943

    2. XM_015293223.3 → XP_015148709.2  caspase-2 isoform X1

      UniProtKB/Swiss-Prot
      Q98943
      Related
      ENSGALP00010035672.1, ENSGALT00010058670.1
      Conserved Domains (2) summary
      cd00032
      Location:162 → 417
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08332
      Location:7 → 93
      CARD_CASP2; Caspase activation and recruitment domain of Caspase-2

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      77820249..77846248 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046906734.1 → XP_046762690.1  caspase-2 isoform X1

      UniProtKB/Swiss-Prot
      Q98943

    2. XM_046906735.1 → XP_046762691.1  caspase-2 isoform X1

      UniProtKB/Swiss-Prot
      Q98943
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q98943.2 GenPept UniProtKB/Swiss-Prot:Q98943

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials