nan nanchung [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: nanprovided by FlyBase
Official Full Name: nanchungprovided by FlyBase
Primary source: FLYBASE:FBgn0036414
Locus tag: Dmel_CG5842
See related: AllianceGenome:FB:FBgn0036414
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5842; CT18317; Dmel\CG5842; DmNan; Iav; Nan; NAN; OCR; TRPV
Summary: Enables mechanosensitive ion channel activity. Involved in several processes, including negative gravitaxis; sensory perception of mechanical stimulus; and startle response. Predicted to be part of cation channel complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including appendage; chordotonal organ precursor cell; labellum; local interneuron of adult antennal lobe; and sensory system. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease axonal type 2C; keratosis (multiple); migraine (multiple); motor neuron disease (multiple); and osteochondrodysplasia (multiple). Orthologous to several human genes including TRPV5 (transient receptor potential cation channel subfamily V member 5) and TRPV6 (transient receptor potential cation channel subfamily V member 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 70D3-70D3; 3-42 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (14186249..14189648, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (14179349..14182748, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nanchung and Inactive define pore properties of the native auditory transduction channel in Drosophila.
Title: Nanchung and Inactive define pore properties of the native auditory transduction channel in Drosophila.
The transient receptor potential channels NOMPC, NANCHUNG, and INACTIVE, but not the dmPIEZO channel, are implicated in mechanotransduction and/or signal amplification for the detection of sound by the larval Cho neurons.
Title: Sound response mediated by the TRP channels NOMPC, NANCHUNG, and INACTIVE in chordotonal organs of Drosophila larvae.
identification of two Drosophila melanogaster transient receptor potential channels needed for sensing humidity: water witch (wtrw), which is required to detect moist air, and nanchung (nan), which is involved in detecting dry air
Title: Drosophila hygrosensation requires the TRP channels water witch and nanchung.
Nan mediates hypo-osmotically activated calcium influx and cation currents; expressed in vivo exclusively in chordotonal neurons and localized to their sensory cilia; essential component of the chordotonal mechanotransducer
Title: A TRPV family ion channel required for hearing in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
contributes_to calcium channel activity	IPI Inferred from Physical Interaction more info	PubMed
enables calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables mechanosensitive monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables mechanosensitive monoatomic ion channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables monoatomic cation channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of adult walking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in detection of mechanical stimulus involved in sensory perception	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of mechanical stimulus involved in sensory perception of sound	IGI Inferred from Genetic Interaction more info	PubMed
involved_in detection of mechanical stimulus involved in sensory perception of touch	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of mechanosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic cation transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in monoatomic ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in negative gravitaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular process controlling posture	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mechanosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to auditory stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in response to humidity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in startle response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of calcium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of cation channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of cation channel complex	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: nanchung

Names: CG5842-PA; CG5842-PB; NANCHUNG; nan-PA; nan-PB; transient receptor potential vanilloid

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

14186249..14189648 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_140439.3 → NP_648696.2 nanchung, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_648696.2

Status: REVIEWED

UniProtKB/TrEMBL

Q7Z077, Q9VUD5

Related

FBpp0088509

Conserved Domains (4) summary

cd00204
Location:178 → 329

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam00520
Location:519 → 727

Ion_trans; Ion transport protein

pfam12796
Location:184 → 311

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:179 → 229

ANK; ANK repeat [structural motif]
NM_001274904.1 → NP_001261833.1 nanchung, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261833.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PI57

Conserved Domains (4) summary

cd00204
Location:178 → 329

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam00520
Location:519 → 727

Ion_trans; Ion transport protein

pfam12796
Location:184 → 311

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:179 → 229

ANK; ANK repeat [structural motif]