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    NUMB NUMB, endocytic adaptor protein [ Gallus gallus (chicken) ]

    Gene ID: 395639, updated on 10-Oct-2024

    Summary

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    Symbol
    NUMBprovided by CGNC
    Full Name
    NUMB, endocytic adaptor proteinprovided by CGNC
    Primary source
    CGNC:49418
    See related
    Ensembl:ENSGALG00010020945
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See NUMB in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 5 NC_052536.1 (25688341..25818698)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 5 NC_052577.1 (25655039..25785313)

    Chromosome 5 - NC_052536.1Genomic Context describing neighboring genes Neighboring gene prostaglandin reductase 2 Neighboring gene ELM2 and Myb/SANT domain containing 1 Neighboring gene dynein axonemal light chain 1 Neighboring gene acyl-coenzyme A thioesterase 1 Neighboring gene acyl-coenzyme A thioesterase 6 Neighboring gene translation initiation factor IF-2-like Neighboring gene microRNA 6587 Neighboring gene ribosomal oxygenase 1 Neighboring gene papilin, proteoglycan like sulfated glycoprotein Neighboring gene uncharacterized LOC121111006 Neighboring gene translation initiation factor IF-2-like Neighboring gene presenilin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Asymmetric localization of numb in the chick somite and the influence of myogenic signals. Holowacz T, et al. Dev Dyn, 2006 Mar. PMID 16425215, Free PMC Article
    2. Transitin, a nestin-like intermediate filament protein, mediates cortical localization and the lateral transport of Numb in mitotic avian neuroepithelial cells. Wakamatsu Y, et al. Development, 2007 Jul. PMID 17522158
    3. NUMB localizes in the basal cortex of mitotic avian neuroepithelial cells and modulates neuronal differentiation by binding to NOTCH-1. Wakamatsu Y, et al. Neuron, 1999 May. PMID 10402194
    4. Rbfox3-regulated alternative splicing of Numb promotes neuronal differentiation during development. Kim KK, et al. J Cell Biol, 2013 Feb 18. PMID 23420872, Free PMC Article
    5. Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones. Arimura N, et al. Mol Cell Biol, 2005 Nov. PMID 16260611, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rbfox3-dependent Numb alternative splicing plays an important role in the progression of neuronal differentiation during vertebrate development.
      Title: Rbfox3-regulated alternative splicing of Numb promotes neuronal differentiation during development.
    2. transitin has important roles in determining the intracellular localization of Numb, which regulates neurogenesis in the developing nervous system of avian embryos
      Title: Transitin, a nestin-like intermediate filament protein, mediates cortical localization and the lateral transport of Numb in mitotic avian neuroepithelial cells.
    3. Numb protein is asymmetrically localized in a cortical crescent on the basal side of dividing cells in the dorsomedial lip of the dermomyotome and is subsequently uniformly distributed throughout differentiated myotomal cells.
      Title: Asymmetric localization of numb in the chick somite and the influence of myogenic signals.
    4. Rho kinase phosphorylates CRMP-2, and inactivates the ability of CRMP-2 to promote microtubule assembly and Numb-mediated endocytosis, during growth cone collapse
      Title: Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cadherin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein numb homolog
    Names
    numb homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204835.3 → NP_990166.3  protein numb homolog

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000214
      UniProtKB/TrEMBL
      A0A0D4WTY6, Q9PW30, T1P3Y7
      Conserved Domains (2) summary
      cd01268
      Location:23 → 157
      PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
      pfam06311
      Location:250 → 328
      NumbF; NUMB domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      25688341..25818698
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046941390.1 → XP_046797346.1  protein numb homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZF56

    2. XM_046941389.1 → XP_046797345.1  protein numb homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZF56

    3. XM_040700610.2 → XP_040556544.1  protein numb homolog isoform X6

      UniProtKB/TrEMBL
      A0A0D4WTY6, Q9PW30, T1P3Y7
      Conserved Domains (2) summary
      cd01268
      Location:23 → 157
      PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
      pfam06311
      Location:250 → 328
      NumbF; NUMB domain

    4. XM_046941392.1 → XP_046797348.1  protein numb homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZF56

    5. XM_040700596.2 → XP_040556530.1  protein numb homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZF56, T1P426
      Conserved Domains (1) summary
      cd01268
      Location:23 → 183
      PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

    6. XM_046941393.1 → XP_046797349.1  protein numb homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZF56

    7. XM_040700598.2 → XP_040556532.1  protein numb homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZF56, T1P426
      Conserved Domains (1) summary
      cd01268
      Location:23 → 183
      PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

    8. XM_015286935.4 → XP_015142421.2  protein numb homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZF56, T1P426
      Conserved Domains (1) summary
      cd01268
      Location:23 → 183
      PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

    9. XM_025150567.3 → XP_025006335.2  protein numb homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZF56, T1P426
      Conserved Domains (1) summary
      cd01268
      Location:23 → 183
      PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

    10. XM_046941399.1 → XP_046797355.1  protein numb homolog isoform X6

      UniProtKB/TrEMBL
      A0A0D4WTY6

    11. XM_046941397.1 → XP_046797353.1  protein numb homolog isoform X3

      UniProtKB/TrEMBL
      A0A8V0ZGD0

    12. XM_015286934.4 → XP_015142420.2  protein numb homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZF56, T1P426
      Related
      ENSGALP00010029895.1, ENSGALT00010050637.1
      Conserved Domains (1) summary
      cd01268
      Location:23 → 183
      PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

    13. XM_015286941.4 → XP_015142427.2  protein numb homolog isoform X4

      UniProtKB/TrEMBL
      A0A0D4WTI4, A0A8V0ZMI5
      Related
      ENSGALP00010029889.1, ENSGALT00010050626.1
      Conserved Domains (1) summary
      cd01268
      Location:23 → 183
      PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

    14. XM_015286938.4 → XP_015142424.2  protein numb homolog isoform X2

      UniProtKB/TrEMBL
      T1P426
      Conserved Domains (1) summary
      cd01268
      Location:23 → 168
      PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

    15. XM_015286942.4 → XP_015142428.2  protein numb homolog isoform X5

      UniProtKB/TrEMBL
      A0A0D4WTI4
      Conserved Domains (1) summary
      cd01268
      Location:23 → 168
      PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

    16. XM_015286939.4 → XP_015142425.2  protein numb homolog isoform X3

      UniProtKB/TrEMBL
      A0A8V0ZGD0, T1P426
      Related
      ENSGALP00010029887.1, ENSGALT00010050623.1
      Conserved Domains (1) summary
      cd01268
      Location:23 → 157
      PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

    17. XM_015286936.4 → XP_015142422.2  protein numb homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZF56, T1P426
      Conserved Domains (1) summary
      cd01268
      Location:23 → 183
      PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

    18. XM_040700600.2 → XP_040556534.1  protein numb homolog isoform X2

      UniProtKB/TrEMBL
      T1P426
      Conserved Domains (1) summary
      cd01268
      Location:23 → 168
      PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

    19. XM_040700608.2 → XP_040556542.1  protein numb homolog isoform X5

      UniProtKB/TrEMBL
      A0A0D4WTI4
      Conserved Domains (1) summary
      cd01268
      Location:23 → 168
      PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

    20. XM_015286940.4 → XP_015142426.2  protein numb homolog isoform X3

      UniProtKB/TrEMBL
      A0A8V0ZGD0, T1P426
      Related
      ENSGALP00010029891.1, ENSGALT00010050632.1
      Conserved Domains (1) summary
      cd01268
      Location:23 → 157
      PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

    21. XM_040700612.2 → XP_040556546.1  protein numb homolog isoform X6

      UniProtKB/TrEMBL
      A0A0D4WTY6, Q9PW30, T1P3Y7
      Conserved Domains (2) summary
      cd01268
      Location:23 → 157
      PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
      pfam06311
      Location:250 → 328
      NumbF; NUMB domain

    22. XM_046941391.1 → XP_046797347.1  protein numb homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZF56

    23. XM_015286937.4 → XP_015142423.2  protein numb homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZF56, T1P426
      Conserved Domains (1) summary
      cd01268
      Location:23 → 183
      PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

    24. XM_046941396.1 → XP_046797352.1  protein numb homolog isoform X3

      UniProtKB/TrEMBL
      A0A8V0ZGD0

    25. XM_046941398.1 → XP_046797354.1  protein numb homolog isoform X6

      UniProtKB/TrEMBL
      A0A0D4WTY6

    26. XM_025150568.3 → XP_025006336.2  protein numb homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZF56, T1P426
      Conserved Domains (1) summary
      cd01268
      Location:23 → 183
      PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

    27. XM_046941394.1 → XP_046797350.1  protein numb homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZF56

    28. XM_046941395.1 → XP_046797351.1  protein numb homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZF56

    29. XM_040700606.2 → XP_040556540.1  protein numb homolog isoform X3

      UniProtKB/TrEMBL
      A0A8V0ZGD0, T1P426
      Conserved Domains (1) summary
      cd01268
      Location:23 → 157
      PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      25655039..25785313
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046917724.1 → XP_046773680.1  protein numb homolog isoform X1

    2. XM_046917723.1 → XP_046773679.1  protein numb homolog isoform X1

    3. XM_046917745.1 → XP_046773701.1  protein numb homolog isoform X6

    4. XM_046917729.1 → XP_046773685.1  protein numb homolog isoform X1

    5. XM_046917726.1 → XP_046773682.1  protein numb homolog isoform X1

    6. XM_046917731.1 → XP_046773687.1  protein numb homolog isoform X1

    7. XM_046917730.1 → XP_046773686.1  protein numb homolog isoform X1

    8. XM_046917725.1 → XP_046773681.1  protein numb homolog isoform X1

    9. XM_046917733.1 → XP_046773689.1  protein numb homolog isoform X1

    10. XM_046917748.1 → XP_046773704.1  protein numb homolog isoform X6

    11. XM_046917740.1 → XP_046773696.1  protein numb homolog isoform X3

    12. XM_046917721.1 → XP_046773677.1  protein numb homolog isoform X1

    13. XM_046917742.1 → XP_046773698.1  protein numb homolog isoform X4

    14. XM_046917735.1 → XP_046773691.1  protein numb homolog isoform X2

    15. XM_046917743.1 → XP_046773699.1  protein numb homolog isoform X5

    16. XM_046917737.1 → XP_046773693.1  protein numb homolog isoform X3

    17. XM_046917722.1 → XP_046773678.1  protein numb homolog isoform X1

    18. XM_046917736.1 → XP_046773692.1  protein numb homolog isoform X2

    19. XM_046917744.1 → XP_046773700.1  protein numb homolog isoform X5

    20. XM_046917738.1 → XP_046773694.1  protein numb homolog isoform X3

    21. XM_046917746.1 → XP_046773702.1  protein numb homolog isoform X6

    22. XM_046917727.1 → XP_046773683.1  protein numb homolog isoform X1

    23. XM_046917728.1 → XP_046773684.1  protein numb homolog isoform X1

    24. XM_046917739.1 → XP_046773695.1  protein numb homolog isoform X3

    25. XM_046917747.1 → XP_046773703.1  protein numb homolog isoform X6

    26. XM_046917732.1 → XP_046773688.1  protein numb homolog isoform X1

    27. XM_046917734.1 → XP_046773690.1  protein numb homolog isoform X1

    28. XM_046917741.1 → XP_046773697.1  protein numb homolog isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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