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    HAS2 hyaluronan synthase 2 [ Gallus gallus (chicken) ]

    Gene ID: 395594, updated on 10-Oct-2024

    Summary

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    Symbol
    HAS2provided by CGNC
    Full Name
    hyaluronan synthase 2provided by CGNC
    Primary source
    CGNC:49391
    See related
    Ensembl:ENSGALG00010009506
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See HAS2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (136351938..136371326, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (136559987..136579429, complement)

    Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112531737 Neighboring gene uncharacterized LOC107052785 Neighboring gene uncharacterized LOC101751629 Neighboring gene uncharacterized LOC107052800 Neighboring gene uncharacterized LOC121109911

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Increased hyaluronan synthase-2 mRNA expression and hyaluronan accumulation with choroidal thickening: response during recovery from induced myopia. Rada JA, et al. Invest Ophthalmol Vis Sci, 2010 Dec. PMID 20574026, Free PMC Article
    2. Hyaluronan accumulates around differentiating neurons in spinal cord of chicken embryos. Mészár Z, et al. Brain Res Bull, 2008 Mar 18. PMID 18331908
    3. Hyaluronan in limb morphogenesis. Li Y, et al. Dev Biol, 2007 May 15. PMID 17362908, Free PMC Article
    4. Characterization and molecular evolution of a vertebrate hyaluronan synthase gene family. Spicer AP, et al. J Biol Chem, 1998 Jan 23. PMID 9442026
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hyaluron accumulation is initiated by a rapid increase in choroidal expression of the HAS2 gene in response to myopic defocus.
      Title: Increased hyaluronan synthase-2 mRNA expression and hyaluronan accumulation with choroidal thickening: response during recovery from induced myopia.
    2. findings suggest a crucial role of HA during neuronal development. We propose that HA may be involved in cell migration and axonal growth in the developing spinal cord.
      Title: Hyaluronan accumulates around differentiating neurons in spinal cord of chicken embryos.
    3. Has2 is abundantly expressed by distal subridge mesodermal cells of chick limb bud and apical ectodermal ridge; Has2 overexpression in the mesoderm in vivo leads to formation of shortened and severely malformed limbs lacking one or more skeletal elements.
      Title: Hyaluronan in limb morphogenesis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables hyaluronan synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in extracellular matrix assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in extracellular polysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in hyaluronan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hyaluronan synthase 2
    Names
    HA synthase 2
    hyaluronate synthase 2
    hyaluronic acid synthase 2
    NP_990137.2
    XP_040531402.1
    XP_046766285.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204806.3 → NP_990137.2  hyaluronan synthase 2

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000044
      UniProtKB/Swiss-Prot
      O57424
      Related
      ENSGALP00010013118.1, ENSGALT00010022704.1
      Conserved Domains (1) summary
      cd06434
      Location:84 → 361
      GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      136351938..136371326 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040675468.2 → XP_040531402.1  hyaluronan synthase 2 isoform X1

      UniProtKB/Swiss-Prot
      O57424
      Conserved Domains (1) summary
      cd06434
      Location:84 → 361
      GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      136559987..136579429 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046910329.1 → XP_046766285.1  hyaluronan synthase 2 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O57424.2 GenPept UniProtKB/Swiss-Prot:O57424

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials