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    ROBO1 roundabout guidance receptor 1 [ Gallus gallus (chicken) ]

    Gene ID: 395292, updated on 17-Aug-2024

    Summary

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    Symbol
    ROBO1provided by CGNC
    Full Name
    roundabout guidance receptor 1provided by CGNC
    Primary source
    CGNC:49246
    See related
    Ensembl:ENSGALG00010007360
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See ROBO1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (96051998..96759720)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (96095391..96803056)

    Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101748284 Neighboring gene uncharacterized LOC121107708 Neighboring gene uncharacterized LOC121107710 Neighboring gene heat shock transcription factor Y3 Neighboring gene uncharacterized LOC121108368 Neighboring gene uncharacterized LOC121108371 Neighboring gene uncharacterized LOC121108369

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Convergent differential regulation of SLIT-ROBO axon guidance genes in the brains of vocal learners. Wang R, et al. J Comp Neurol, 2015 Apr 15. PMID 25424606, Free PMC Article
    2. Slits affect the timely migration of neural crest cells via Robo receptor. Giovannone D, et al. Dev Dyn, 2012 Aug. PMID 22689303, Free PMC Article
    3. Implication of SLIT3-ROBO1/ROBO2 in granulosa cell proliferation, differentiation and follicle selection in the prehierarchical follicles of hen ovary. Xu R, et al. Cell Biol Int, 2018 Dec. PMID 30288875
    4. Nerve repulsion by the lens and cornea during cornea innervation is dependent on Robo-Slit signaling and diminishes with neuron age. Schwend T, et al. Dev Biol, 2012 Mar 1. PMID 22236962, Free PMC Article
    5. Slits and Robos in the developing chicken inner ear. Battisti AC, et al. Dev Dyn, 2008 Feb. PMID 18213576, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SLIT3 may play an inhibitory effect on granulosa cell (GC) proliferation, differentiation and follicle selection, and these suppressive actions of SLIT3 in the GC proliferation can be prohibited by the siRNA-mediated knockdown of ROBO1 and ROBO2 receptors.
      Title: Implication of SLIT3-ROBO1/ROBO2 in granulosa cell proliferation, differentiation and follicle selection in the prehierarchical follicles of hen ovary.
    2. The ROBO1 differential expression in the songbird high vocal center relative to the surrounding arcopallium was transiently and developmentally upregulated during critical periods of song learning
      Title: Convergent differential regulation of SLIT-ROBO axon guidance genes in the brains of vocal learners.
    3. Slits affect the timely migration of neural crest cells via Robo receptor.
      Title: Slits affect the timely migration of neural crest cells via Robo receptor.
    4. Data show that Slits 1, 2 and 3 expression in the cornea and lens persisted during all stages of cornea innervation, and Robo1 expression was developmentally regulated in trigeminal cell bodies, expressed robustly during nerve ring formation (E5-8).
      Title: Nerve repulsion by the lens and cornea during cornea innervation is dependent on Robo-Slit signaling and diminishes with neuron age.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables axon guidance receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Roundabout signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in axon guidance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in axon midline choice point recognition IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in synapse organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    roundabout homolog 1
    Names
    Roundabout1 protein
    roundabout, axon guidance receptor, homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      96051998..96759720
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046904542.1 → XP_046760498.1  roundabout homolog 1 isoform X3

      UniProtKB/TrEMBL
      A0A8V0XNE0
      Related
      ENSGALP00010009701.1, ENSGALT00010017550.1

    2. XM_046904541.1 → XP_046760497.1  roundabout homolog 1 isoform X2

      UniProtKB/TrEMBL
      A0A8V0XUM4, A0A8V0XXE9
      Related
      ENSGALP00010009698.1, ENSGALT00010017545.1

    3. XM_040653484.2 → XP_040509418.1  roundabout homolog 1 isoform X5

      UniProtKB/TrEMBL
      A0A8V0XXE9
      Conserved Domains (6) summary
      cd00063
      Location:455 → 541
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:672 → 758
      fn3; Fibronectin type III domain
      cd05724
      Location:64 → 149
      IgI_2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd05725
      Location:156 → 238
      IgI_3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd05726
      Location:246 → 343
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd20952
      Location:350 → 436
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains

    4. XM_046904536.1 → XP_046760492.1  roundabout homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0A8V0XXE9

    5. XM_040653486.1 → XP_040509420.1  roundabout homolog 1 isoform X6

      UniProtKB/TrEMBL
      A0A3Q3A4U3
      Conserved Domains (5) summary
      smart00409
      Location:241 → 329
      IG; Immunoglobulin
      smart00410
      Location:149 → 228
      IG_like; Immunoglobulin like
      cd00063
      Location:445 → 531
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:150 → 155
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:54 → 134
      Ig; Immunoglobulin domain

    6. XM_416673.8 → XP_416673.5  roundabout homolog 1 isoform X4

      UniProtKB/TrEMBL
      A0A3Q3A4U3, A0A8V0XNC3
      Related
      ENSGALP00010009686.1, ENSGALT00010017525.1
      Conserved Domains (7) summary
      cd00063
      Location:525 → 611
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:742 → 828
      fn3; Fibronectin type III domain
      cd05724
      Location:134 → 219
      IgI_2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd05725
      Location:226 → 308
      IgI_3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd05726
      Location:316 → 413
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:29 → 127
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:420 → 506
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains

    7. XM_025144725.3 → XP_025000493.1  roundabout homolog 1 isoform X7

      UniProtKB/TrEMBL
      A0A3Q3A4U3
      Conserved Domains (6) summary
      cd00063
      Location:416 → 502
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:633 → 719
      fn3; Fibronectin type III domain
      cd05724
      Location:25 → 110
      IgI_2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd05725
      Location:117 → 199
      IgI_3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd05726
      Location:207 → 304
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd20952
      Location:311 → 397
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      96095391..96803056
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040659615.2 → XP_040515549.1  roundabout homolog 1 isoform X3

      UniProtKB/TrEMBL
      A0A8V0XNE0
      Conserved Domains (7) summary
      cd00063
      Location:561 → 647
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:778 → 864
      fn3; Fibronectin type III domain
      cd05724
      Location:173 → 258
      IgI_2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd05725
      Location:265 → 347
      IgI_3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd05726
      Location:352 → 449
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:68 → 166
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:456 → 542
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains

    2. XM_046909467.1 → XP_046765423.1  roundabout homolog 1 isoform X2

      UniProtKB/TrEMBL
      A0A8V0XUM4, A0A8V0XXE9

    3. XM_046909469.1 → XP_046765425.1  roundabout homolog 1 isoform X5

      UniProtKB/TrEMBL
      A0A8V0XXE9

    4. XM_046909466.1 → XP_046765422.1  roundabout homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0A8V0XXE9

    5. XM_040659620.1 → XP_040515554.1  roundabout homolog 1 isoform X6

      UniProtKB/TrEMBL
      A0A3Q3A4U3
      Conserved Domains (5) summary
      smart00409
      Location:241 → 329
      IG; Immunoglobulin
      smart00410
      Location:149 → 228
      IG_like; Immunoglobulin like
      cd00063
      Location:445 → 531
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:150 → 155
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:54 → 134
      Ig; Immunoglobulin domain

    6. XM_040659617.2 → XP_040515551.1  roundabout homolog 1 isoform X4

      UniProtKB/TrEMBL
      A0A3Q3A4U3, A0A8V0XNC3
      Conserved Domains (7) summary
      cd00063
      Location:525 → 611
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:742 → 828
      fn3; Fibronectin type III domain
      cd05724
      Location:134 → 219
      IgI_2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd05725
      Location:226 → 308
      IgI_3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd05726
      Location:316 → 413
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:29 → 127
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:420 → 506
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains

    7. XM_040659621.2 → XP_040515555.1  roundabout homolog 1 isoform X7

      UniProtKB/TrEMBL
      A0A3Q3A4U3
      Conserved Domains (6) summary
      cd00063
      Location:416 → 502
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:633 → 719
      fn3; Fibronectin type III domain
      cd05724
      Location:25 → 110
      IgI_2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd05725
      Location:117 → 199
      IgI_3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd05726
      Location:207 → 304
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd20952
      Location:311 → 397
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
    Nucleotide Protein
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