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    ATVR1 serine/threonine-protein kinase receptor [ Gallus gallus (chicken) ]

    Gene ID: 395246, updated on 10-Oct-2024

    Summary

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    Official Symbol
    ATVR1provided by CGNC
    Official Full Name
    serine/threonine-protein kinase receptorprovided by CGNC
    Primary source
    CGNC:9529
    See related
    Ensembl:ENSGALG00010010745
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    ALK2; ACVR1
    Orthologs
    human mouse all
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    Genomic context

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    See ATVR1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 7 NC_052538.1 (35870698..35915583, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 7 NC_052579.1 (35790133..35835018, complement)

    Chromosome 7 - NC_052538.1Genomic Context describing neighboring genes Neighboring gene cytohesin 1 interacting protein Neighboring gene activin A receptor type 1C Neighboring gene microRNA 6546 Neighboring gene uridine phosphorylase 2 Neighboring gene coiled-coil domain containing 148 Neighboring gene plakophilin 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ACVR1 p.Q207E causes classic fibrodysplasia ossificans progressiva and is functionally distinct from the engineered constitutively active ACVR1 p.Q207D variant. Haupt J, et al. Hum Mol Genet, 2014 Oct 15. PMID 24852373, Free PMC Article
    2. Transforming growth factor beta (TGFbeta ) signaling via differential activation of activin receptor-like kinases 2 and 5 during cardiac development. Role in regulating parasympathetic responsiveness. Ward SM, et al. J Biol Chem, 2002 Dec 20. PMID 12393881
    3. Effects of follistatin overexpression on cell differentiation in the chick embryo retina. Moreira EF, et al. Dev Biol, 2006 Oct 1. PMID 16872597
    4. Activin receptor-like kinase 2 and Smad6 regulate epithelial-mesenchymal transformation during cardiac valve formation. Desgrosellier JS, et al. Dev Biol, 2005 Apr 1. PMID 15766759
    5. ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development. Zhang D, et al. J Bone Miner Res, 2003 Sep. PMID 12968668

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of ACVR1Q207D-c.a. caused severe skeletal malformations in >90% of injected embryos with large ectopic cartilage condensations in all major limb joints.
      Title: ACVR1 p.Q207E causes classic fibrodysplasia ossificans progressiva and is functionally distinct from the engineered constitutively active ACVR1 p.Q207D variant.
    2. TGFB ligands and receptors show dynamic and frequently overlapping expression patterns in numerous embryonic cell layers and structures
      Title: Embryonic expression of the transforming growth factor beta ligand and receptor genes in chicken.
    3. the expression of ROCK1 is up-regulated at the onset of endocardial epithelial-mesenchymal transition and signaling mediated by TGFbeta3/ALK2 together with BMP is involved in the expression of ROCK1
      Title: ROCK1 expression is regulated by TGFbeta3 and ALK2 during valvuloseptal endocardial cushion formation.
    4. ALK2 was expressed in isolated chick osteoblasts and chondrocytes and specifically mediated BMP signaling.
      Title: ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development.
    5. data suggest that activin receptor-like kinase (ALK) 2 activation may stimulate epithelial-mesenchymal transformation (EMT) in the atrioventricular cushion and that Smad6 may act downstream of ALK2 to negatively regulate EMT
      Title: Activin receptor-like kinase 2 and Smad6 regulate epithelial-mesenchymal transformation during cardiac valve formation.
    6. Taken together with previous in vitro studies, our results suggest that activin is a powerful regulator of neuronal differentiation in the central nervous system.
      Title: Effects of follistatin overexpression on cell differentiation in the chick embryo retina.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables SMAD binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transforming growth factor beta receptor activity, type I IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in dorsal/ventral pattern formation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in heart development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of BMP receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    activin receptor type-1
    Names
    activin A receptor type 1
    activin A receptor, type I
    activin receptor type I
    type I TGF B receptor
    NP_001383422.1
    NP_001383423.1
    NP_001383424.1
    NP_001383425.1
    NP_001383426.1
    NP_001383427.1
    NP_989891.2
    XP_015145612.2
    XP_015145614.1
    XP_015145616.1
    XP_025007852.1
    XP_040559188.1
    XP_040559189.1
    XP_040559190.1
    XP_046776892.1
    XP_046776893.1
    XP_046776894.1
    XP_046776895.1
    XP_046776896.1
    XP_046776897.1
    XP_046776898.1
    XP_046776899.1
    XP_046776900.1
    XP_046776901.1
    XP_046776902.1
    XP_046776903.1
    XP_046776905.1
    XP_046776906.1
    XP_046776907.1
    XP_046776908.1
    XP_046799362.1
    XP_046799363.1
    XP_046799364.1
    XP_046799365.1
    XP_046799366.1
    XP_046799367.1
    XP_046799368.1
    XP_046799369.1
    XP_046799370.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001396493.1 → NP_001383422.1  activin receptor type-1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000236
      UniProtKB/Swiss-Prot
      Q90ZK6, Q9YH45
      UniProtKB/TrEMBL
      A0A8V0Y1P7
      Conserved Domains (3) summary
      cd14142
      Location:197 → 494
      STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
      pfam01064
      Location:29 → 95
      Activin_recp; Activin types I and II receptor domain
      pfam08515
      Location:174 → 201
      TGF_beta_GS; Transforming growth factor beta type I GS-motif

    2. NM_001396494.1 → NP_001383423.1  activin receptor type-1 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000236
      UniProtKB/TrEMBL
      A0A8V0Y1P7
      Conserved Domains (2) summary
      smart00467
      Location:183 → 213
      GS; GS motif
      cl21453
      Location:207 → 438
      PKc_like; Protein Kinases, catalytic domain

    3. NM_001396495.1 → NP_001383424.1  activin receptor type-1 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000236
      Conserved Domains (2) summary
      smart00467
      Location:183 → 213
      GS; GS motif
      cl21453
      Location:207 → 346
      PKc_like; Protein Kinases, catalytic domain

    4. NM_001396496.1 → NP_001383425.1  activin receptor type-1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000236
      UniProtKB/Swiss-Prot
      Q90ZK6, Q9YH45
      UniProtKB/TrEMBL
      A0A8V0Y1P7
      Related
      ENSGALP00010014502.1, ENSGALT00010025728.1
      Conserved Domains (3) summary
      cd14142
      Location:197 → 494
      STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
      pfam01064
      Location:29 → 95
      Activin_recp; Activin types I and II receptor domain
      pfam08515
      Location:174 → 201
      TGF_beta_GS; Transforming growth factor beta type I GS-motif

    5. NM_001396497.1 → NP_001383426.1  activin receptor type-1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000236
      UniProtKB/Swiss-Prot
      Q90ZK6, Q9YH45
      UniProtKB/TrEMBL
      A0A8V0Y1P7
      Conserved Domains (3) summary
      cd14142
      Location:197 → 494
      STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
      pfam01064
      Location:29 → 95
      Activin_recp; Activin types I and II receptor domain
      pfam08515
      Location:174 → 201
      TGF_beta_GS; Transforming growth factor beta type I GS-motif

    6. NM_001396498.1 → NP_001383427.1  activin receptor type-1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000236
      UniProtKB/Swiss-Prot
      Q90ZK6, Q9YH45
      UniProtKB/TrEMBL
      A0A8V0Y1P7
      Conserved Domains (3) summary
      cd14142
      Location:197 → 494
      STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
      pfam01064
      Location:29 → 95
      Activin_recp; Activin types I and II receptor domain
      pfam08515
      Location:174 → 201
      TGF_beta_GS; Transforming growth factor beta type I GS-motif

    7. NM_204560.2 → NP_989891.2  activin receptor type-1 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000236
      UniProtKB/TrEMBL
      A0A8V0Y1P7
      Related
      ENSGALP00010014519.1, ENSGALT00010025763.1
      Conserved Domains (2) summary
      smart00467
      Location:183 → 213
      GS; GS motif
      cd14142
      Location:207 → 504
      STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052538.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      35870698..35915583 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046943411.1 → XP_046799367.1  activin receptor type-1 isoform X7

      UniProtKB/Swiss-Prot
      Q90ZK6, Q9YH45

    2. XM_046943413.1 → XP_046799369.1  activin receptor type-1 isoform X7

      UniProtKB/Swiss-Prot
      Q90ZK6, Q9YH45

    3. XM_015290130.3 → XP_015145616.1  activin receptor type-1 isoform X7

      UniProtKB/Swiss-Prot
      Q90ZK6, Q9YH45
      UniProtKB/TrEMBL
      A0A8V0Y1P7
      Related
      ENSGALP00010014498.1, ENSGALT00010025721.1
      Conserved Domains (3) summary
      cd14142
      Location:197 → 494
      STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
      pfam01064
      Location:29 → 95
      Activin_recp; Activin types I and II receptor domain
      pfam08515
      Location:174 → 201
      TGF_beta_GS; Transforming growth factor beta type I GS-motif

    4. XM_046943410.1 → XP_046799366.1  activin receptor type-1 isoform X7

      UniProtKB/Swiss-Prot
      Q90ZK6, Q9YH45

    5. XM_040703254.2 → XP_040559188.1  activin receptor type-1 isoform X2

      UniProtKB/TrEMBL
      A0A1D5P2D8, A0A8V0Y1P7
      Related
      ENSGALP00010014510.1, ENSGALT00010025745.1
      Conserved Domains (2) summary
      smart00467
      Location:193 → 223
      GS; GS motif
      cd14142
      Location:217 → 514
      STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1

    6. XM_046943407.1 → XP_046799363.1  activin receptor type-1 isoform X7

      UniProtKB/Swiss-Prot
      Q90ZK6, Q9YH45

    7. XM_046943414.1 → XP_046799370.1  activin receptor type-1 isoform X7

      UniProtKB/Swiss-Prot
      Q90ZK6, Q9YH45

    8. XM_046943409.1 → XP_046799365.1  activin receptor type-1 isoform X7

      UniProtKB/Swiss-Prot
      Q90ZK6, Q9YH45

    9. XM_015290126.4 → XP_015145612.2  activin receptor type-1 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YA71
      Related
      ENSGALP00010014506.1, ENSGALT00010025736.1
      Conserved Domains (2) summary
      smart00467
      Location:257 → 287
      GS; GS motif
      cd14142
      Location:281 → 578
      STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1

    10. XM_046943408.1 → XP_046799364.1  activin receptor type-1 isoform X7

      UniProtKB/Swiss-Prot
      Q90ZK6, Q9YH45

    11. XM_046943412.1 → XP_046799368.1  activin receptor type-1 isoform X7

      UniProtKB/Swiss-Prot
      Q90ZK6, Q9YH45

    12. XM_046943406.1 → XP_046799362.1  activin receptor type-1 isoform X3

      UniProtKB/TrEMBL
      A0A8V0Y6D3

    13. XM_015290128.4 → XP_015145614.1  activin receptor type-1 isoform X3

      UniProtKB/TrEMBL
      A0A8V0Y1R6, A0A8V0Y6D3
      Related
      ENSGALP00010014517.1, ENSGALT00010025754.1
      Conserved Domains (4) summary
      smart00220
      Location:216 → 500
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14142
      Location:209 → 506
      STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
      pfam01064
      Location:37 → 108
      Activin_recp; Activin types I and II receptor domain
      pfam08515
      Location:186 → 213
      TGF_beta_GS; Transforming growth factor beta type I GS-motif

    14. XM_025152084.3 → XP_025007852.1  activin receptor type-1 isoform X4

      UniProtKB/TrEMBL
      A0A8V0Y1P7
      Conserved Domains (3) summary
      cd14142
      Location:207 → 504
      STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
      pfam01064
      Location:36 → 105
      Activin_recp; Activin types I and II receptor domain
      pfam08515
      Location:184 → 211
      TGF_beta_GS; Transforming growth factor beta type I GS-motif

    15. XM_040703255.2 → XP_040559189.1  activin receptor type-1 isoform X5

      UniProtKB/TrEMBL
      A0A8V0Y1P7, A0A8V0YEV4
      Related
      ENSGALP00010014514.1, ENSGALT00010025751.1
      Conserved Domains (2) summary
      smart00467
      Location:182 → 212
      GS; GS motif
      cd14142
      Location:206 → 503
      STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1

    16. XM_040703256.2 → XP_040559190.1  activin receptor type-1 isoform X6

      UniProtKB/TrEMBL
      A0A8V0Y1P7, A0A8V0YA30
      Related
      ENSGALP00010014465.1, ENSGALT00010025667.1
      Conserved Domains (2) summary
      smart00467
      Location:179 → 209
      GS; GS motif
      cd14142
      Location:203 → 500
      STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052579.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      35790133..35835018 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046920949.1 → XP_046776905.1  activin receptor type-1 isoform X7

      UniProtKB/Swiss-Prot
      Q90ZK6, Q9YH45

    2. XM_046920951.1 → XP_046776907.1  activin receptor type-1 isoform X7

      UniProtKB/Swiss-Prot
      Q90ZK6, Q9YH45

    3. XM_046920945.1 → XP_046776901.1  activin receptor type-1 isoform X7

      UniProtKB/Swiss-Prot
      Q90ZK6, Q9YH45

    4. XM_046920947.1 → XP_046776903.1  activin receptor type-1 isoform X7

      UniProtKB/Swiss-Prot
      Q90ZK6, Q9YH45

    5. XM_046920937.1 → XP_046776893.1  activin receptor type-1 isoform X2

      UniProtKB/TrEMBL
      A0A1D5P2D8

    6. XM_046920943.1 → XP_046776899.1  activin receptor type-1 isoform X7

      UniProtKB/Swiss-Prot
      Q90ZK6, Q9YH45

    7. XM_046920952.1 → XP_046776908.1  activin receptor type-1 isoform X7

      UniProtKB/Swiss-Prot
      Q90ZK6, Q9YH45

    8. XM_046920946.1 → XP_046776902.1  activin receptor type-1 isoform X7

      UniProtKB/Swiss-Prot
      Q90ZK6, Q9YH45

    9. XM_046920936.1 → XP_046776892.1  activin receptor type-1 isoform X1

    10. XM_046920944.1 → XP_046776900.1  activin receptor type-1 isoform X7

      UniProtKB/Swiss-Prot
      Q90ZK6, Q9YH45

    11. XM_046920950.1 → XP_046776906.1  activin receptor type-1 isoform X7

      UniProtKB/Swiss-Prot
      Q90ZK6, Q9YH45

    12. XM_046920939.1 → XP_046776895.1  activin receptor type-1 isoform X3

      UniProtKB/TrEMBL
      A0A8V0Y6D3

    13. XM_046920938.1 → XP_046776894.1  activin receptor type-1 isoform X3

      UniProtKB/TrEMBL
      A0A8V0Y6D3

    14. XM_046920940.1 → XP_046776896.1  activin receptor type-1 isoform X4

    15. XM_046920941.1 → XP_046776897.1  activin receptor type-1 isoform X5

      UniProtKB/TrEMBL
      A0A8V0YEV4

    16. XM_046920942.1 → XP_046776898.1  activin receptor type-1 isoform X6

      UniProtKB/TrEMBL
      A0A8V0YA30
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q90ZK6.1 GenPept UniProtKB/Swiss-Prot:Q90ZK6

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