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    WNT6 Wnt family member 6 [ Gallus gallus (chicken) ]

    Gene ID: 395235, updated on 10-Oct-2024

    Summary

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    Symbol
    WNT6provided by CGNC
    Full Name
    Wnt family member 6provided by CGNC
    Primary source
    CGNC:8636
    See related
    Ensembl:ENSGALG00010021142
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See WNT6 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 7 NC_052538.1 (22026370..22035132, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 7 NC_052579.1 (21946158..21954922, complement)

    Chromosome 7 - NC_052538.1Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase 5 regulatory subunit 2 Neighboring gene transfer RNA valine (anticodon GAC) Neighboring gene Wnt family member 10A Neighboring gene cytochrome P450 family 27 subfamily A member 1 Neighboring gene protein kinase AMP-activated non-catalytic subunit gamma 3 Neighboring gene tubulin tyrosine ligase like 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ectodermal Wnt6 is an early negative regulator of limb chondrogenesis in the chicken embryo. Geetha-Loganathan P, et al. BMC Dev Biol, 2010 Mar 25. PMID 20334703, Free PMC Article
    2. Wnt6 controls amniote neural crest induction through the non-canonical signaling pathway. Schmidt C, et al. Dev Dyn, 2007 Sep. PMID 17685490
    3. Role of Wnt-6 in limb myogenesis. Geetha-Loganathan P, et al. Anat Embryol (Berl), 2006 Jun. PMID 16369823
    4. Ectodermal Wnt-6 promotes Myf5-dependent avian limb myogenesis. Geetha-Loganathan P, et al. Dev Biol, 2005 Dec 1. PMID 16271265
    5. Wnt6 marks sites of epithelial transformations in the chick embryo. Schubert FR, et al. Mech Dev, 2002 Jun. PMID 12175501

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study identifies Wnt6 as a candidate mediator of ectodermal chondrogenic inhibition in vivo.
      Title: Ectodermal Wnt6 is an early negative regulator of limb chondrogenesis in the chicken embryo.
    2. Wnt6 has a role in controlling amniote neural crest induction through the non-canonical signaling pathway
      Title: Wnt6 controls amniote neural crest induction through the non-canonical signaling pathway.
    3. Wnt11 and Wnt6 act as factors maintaining the epithelial nature of the dorsomedial and ventrolateral lips of the dermomyotome.
      Title: Regulation of ectodermal Wnt6 expression by the neural tube is transduced by dermomyotomal Wnt11: a mechanism of dermomyotomal lip sustainment.
    4. plays a unique role in promoting limb myogenesis via Pax3, Paraxis, and myogenic regulatory factor 5 in chick embryo
      Title: Ectodermal Wnt-6 promotes Myf5-dependent avian limb myogenesis.
    5. In a study of quail somites transplanted to chick limb buds Wnt-6 is found to be an ectodermal signal that induces somite-derived progenitor cells to form muscle cells during limb development.
      Title: Role of Wnt-6 in limb myogenesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables frizzled binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein Wnt-6
    Names
    wingless-related MMTV integration site 6 homolog
    wingless-type MMTV integration site family member 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007594.3 → NP_001007595.1  protein Wnt-6

      See identical proteins and their annotated locations for NP_001007595.1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000236
      UniProtKB/TrEMBL
      A0A8V0ZHX2
      Conserved Domains (1) summary
      cd19338
      Location:1 → 319
      Wnt_Wnt6; Wnt domain found in protein Wnt-6 and similar proteins

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052538.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      22026370..22035132 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015289781.4 → XP_015145267.1  protein Wnt-6 isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZHX2
      Conserved Domains (1) summary
      cd19338
      Location:1 → 319
      Wnt_Wnt6; Wnt domain found in protein Wnt-6 and similar proteins

    2. XM_015289779.4 → XP_015145265.1  protein Wnt-6 isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZNV6, F1NZU6, Q3C2H6
      Related
      ENSGALP00010030389.1, ENSGALT00010051199.1
      Conserved Domains (1) summary
      cd19338
      Location:34 → 352
      Wnt_Wnt6; Wnt domain found in protein Wnt-6 and similar proteins

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052579.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      21946158..21954922 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046920934.1 → XP_046776890.1  protein Wnt-6 isoform X4

    2. XM_046920933.1 → XP_046776889.1  protein Wnt-6 isoform X3

    3. XM_046920935.1 → XP_046776891.1  protein Wnt-6 isoform X1

      UniProtKB/TrEMBL
      F1NZU6, Q3C2H6
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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