lmnb2.S lamin B2 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: lmnb2.S
Official Full Name: lamin B2 S homeolog
Primary source: Xenbase:XB-GENE-6254662
Locus tag: XELAEV_18009631mg
See related: EnsemblRapid:ENSXLAG00005035107 AllianceGenome:Xenbase:XB-GENE-6254662
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: lmnb2; lmnb2-a; lmnb2-b; lamin-b2; Lamin-L(II)
Summary: Predicted to be a structural constituent of cytoskeleton. Predicted to act upstream of or within several processes, including heterochromatin formation; nucleus organization; and protein localization to nuclear envelope. Predicted to be located in intermediate filament; nuclear envelope; and nuclear lamina. Is expressed in visual system. Human ortholog(s) of this gene implicated in partial lipodystrophy; primary autosomal recessive microcephaly; and progressive myoclonus epilepsy 9. Orthologous to human LMNB2 (lamin B2). [provided by Alliance of Genome Resources, Nov 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 1S

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	1S	NC_054372.1 (82871543..82889471, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	1S	NC_030725.1 (77731676..77749789, complement)

Chromosome 1S - NC_054372.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LIII filaments appear identical to the endogenous lamina, whereas lamin B2 assembles into filaments that are organized less precisely; Lamin A induces sheets of thicker filaments on the endogenous lamina and increases the rigidity of the nuclear envelope
Title: Filaments made from A- and B-type lamins differ in structure and organization.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within heterochromatin formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nuclear envelope organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nuclear migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nuclear pore localization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein localization to nuclear envelope	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in intermediate filament	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in nuclear lamina	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: lamin B2 S homeolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087478.1 → NP_001080947.1 lamin B2 S homeolog

See identical proteins and their annotated locations for NP_001080947.1

Status: PROVISIONAL

Source sequence(s)

BC073219

UniProtKB/TrEMBL

A0A974DV50, A0A974DY79, Q6DDM6, Q6GPC2

Related

ENSXLAP00005104977.1, ENSXLAT00005107018.1

Conserved Domains (3) summary

pfam00038
Location:35 → 391

Filament; Intermediate filament protein

pfam00932
Location:474 → 583

LTD; Lamin Tail Domain

pfam10351
Location:263 → 383

Apt1; Golgi-body localization protein domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054372.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

82871543..82889471 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)