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    cct8 chaperonin containing TCP1, subunit 8 (theta) [ Danio rerio (zebrafish) ]

    Gene ID: 394037, updated on 28-Oct-2024

    Summary

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    Official Symbol
    cct8provided by ZNC
    Official Full Name
    chaperonin containing TCP1, subunit 8 (theta)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-876
    See related
    Ensembl:ENSDARG00000008243 AllianceGenome:ZFIN:ZDB-GENE-040426-876
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fa22h09; zgc:56059; wu:fa22h09
    Summary
    Predicted to enable unfolded protein binding activity. Acts upstream of or within behavioral response to nicotine. Predicted to be part of chaperonin-containing T-complex. Is expressed in brain. Orthologous to human CCT8 (chaperonin containing TCP1 subunit 8). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cct8 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (25329582..25342960, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (25367309..25383225, complement)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene RAB38b, member of RAS oncogene family Neighboring gene transmembrane protein 135 Neighboring gene map3k7 C-terminal like Neighboring gene BTB and CNC homology 1, basic leucine zipper transcription factor 1 b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Nicotine response genetics in the zebrafish. Petzold AM, et al. Proc Natl Acad Sci U S A, 2009 Nov 3. PMID 19858493, Free PMC Article
    2. The spatial-temporal expression and functional divergence of bach homologs in zebrafish Danio rerio. Luo Q, et al. J Fish Biol, 2016 Apr. PMID 26992035
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56059

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within behavioral response to nicotine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of chaperonin-containing T-complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    T-complex protein 1 subunit theta
    Names
    bdav
    bette davis

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201062.1 → NP_957356.1  T-complex protein 1 subunit theta

      See identical proteins and their annotated locations for NP_957356.1

      Status: PROVISIONAL

      Source sequence(s)
      BC050492
      UniProtKB/TrEMBL
      B2GQA3, F6NVA7, Q7ZU96
      Related
      ENSDARP00000003468.5, ENSDART00000009477.6
      Conserved Domains (2) summary
      TIGR02346
      Location:10 → 539
      chap_CCT_theta; T-complex protein 1, theta subunit
      pfam00118
      Location:39 → 528
      Cpn60_TCP1; TCP-1/cpn60 chaperonin family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      25329582..25342960 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005155366.4 → XP_005155423.1  T-complex protein 1 subunit theta isoform X1

      UniProtKB/TrEMBL
      A0A0R4IJT8, A0A8M2B296
      Related
      ENSDARP00000135440.1, ENSDART00000166348.2
      Conserved Domains (2) summary
      TIGR02346
      Location:10 → 539
      chap_CCT_theta; T-complex protein 1, theta subunit
      pfam00118
      Location:39 → 528
      Cpn60_TCP1; TCP-1/cpn60 chaperonin family
    Nucleotide Protein Strain
    Heading Accession and Version

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