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    naprt nicotinate phosphoribosyltransferase [ Danio rerio (zebrafish) ]

    Gene ID: 393864, updated on 2-Nov-2024

    Summary

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    Official Symbol
    naprtprovided by ZNC
    Official Full Name
    nicotinate phosphoribosyltransferaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1897
    See related
    Ensembl:ENSDARG00000027930 AllianceGenome:ZFIN:ZDB-GENE-040426-1897
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    naprt1; zgc:77870
    Summary
    Predicted to enable nicotinate phosphoribosyltransferase activity. Predicted to be involved in NAD salvage and response to oxidative stress. Predicted to act upstream of or within pyridine nucleotide biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alar plate midbrain region; digestive system; midbrain; polster; and pronephric duct. Orthologous to human NAPRT (nicotinate phosphoribosyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See naprt in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (52273446..52314337, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (52461540..52502438, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene H2.0-like homeo box 1 (Drosophila) Neighboring gene rhophilin, Rho GTPase binding protein 1 Neighboring gene collagen alpha-3(IV) chain-like Neighboring gene si:ch1073-287p18.1 Neighboring gene Rho GTPase activating protein 39

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Association of Schizophrenia Risk With Disordered Niacin Metabolism in an Indian Genome-wide Association Study. Periyasamy S, et al. JAMA Psychiatry, 2019 Oct 1. PMID 31268507, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC77870

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nicotinate phosphoribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nicotinate phosphoribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nicotinate phosphoribosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within NAD biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in NAD biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in NAD salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within pyridine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oxidative stress ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nicotinate phosphoribosyltransferase
    Names
    NAPRTase
    nicotinate phosphoribosyltransferase domain containing 1
    nicotinate phosphoribosyltransferase domain-containing protein 1
    NP_957184.2
    XP_005170272.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200890.2 → NP_957184.2  nicotinate phosphoribosyltransferase

      Status: VALIDATED

      Source sequence(s)
      CU550702, EH449770, EH475595, EH587473
      UniProtKB/Swiss-Prot
      Q6P3H4
      UniProtKB/TrEMBL
      A0A8M1PF80, B8JLT0
      Related
      ENSDARP00000035128.5, ENSDART00000038157.6
      Conserved Domains (2) summary
      PLN02885
      Location:14 → 528
      PLN02885; nicotinate phosphoribosyltransferase
      cd01570
      Location:16 → 398
      NAPRTase_A; Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      52273446..52314337 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005170215.5 → XP_005170272.1  nicotinate phosphoribosyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q6P3H4
      UniProtKB/TrEMBL
      A0A8M2BHL0
      Conserved Domains (2) summary
      PLN02885
      Location:14 → 527
      PLN02885; nicotinate phosphoribosyltransferase
      cd01570
      Location:16 → 397
      NAPRTase_A; Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P3H4.2 GenPept UniProtKB/Swiss-Prot:Q6P3H4

    Gene LinkOut

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