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    romo1 reactive oxygen species modulator 1 [ Danio rerio (zebrafish) ]

    Gene ID: 393770, updated on 12-Sep-2024

    Summary

    Official Symbol
    romo1provided by ZNC
    Official Full Name
    reactive oxygen species modulator 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1768
    See related
    Ensembl:ENSDARG00000038076 AllianceGenome:ZFIN:ZDB-GENE-040426-1768
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:73345; zgc:77111
    Summary
    Predicted to be involved in several processes, including positive regulation of reactive oxygen species metabolic process; protein targeting to mitochondrion; and replicative senescence. Predicted to act upstream of or within defense response to bacterium. Predicted to be located in mitochondrion. Predicted to be part of TIM23 mitochondrial import inner membrane translocase complex. Is expressed in several structures, including alar plate midbrain region; liver; optic tectum; optic vesicle; and retina. Orthologous to human ROMO1 (reactive oxygen species modulator 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

    See romo1 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (50401585..50404775, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (50402366..50405556, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496022 Neighboring gene cytochrome c-1 Neighboring gene ERGIC and golgi 3 Neighboring gene myelocytomatosis oncogene homolog Neighboring gene uncharacterized LOC137495893

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Clone Names

    • MGC73345

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in cellular response to reactive oxygen species ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of reactive oxygen species metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein import into mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein insertion into mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in replicative senescence ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of TIM23 mitochondrial import inner membrane translocase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    reactive oxygen species modulator 1
    Names
    ROS modulator 1
    protein MGR2 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200797.4NP_957091.1  reactive oxygen species modulator 1

      See identical proteins and their annotated locations for NP_957091.1

      Status: VALIDATED

      Source sequence(s)
      BI883966, EH450114, EH509025, EH545431
      UniProtKB/Swiss-Prot
      Q6NYD1
      Related
      ENSDARP00000055509.5, ENSDART00000055510.6
      Conserved Domains (1) summary
      pfam10247
      Location:1580
      Romo1; Reactive mitochondrial oxygen species modulator 1

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      50401585..50404775 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)