PGRP-LC Peptidoglycan recognition protein LC [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: PGRP-LCprovided by FlyBase
Official Full Name: Peptidoglycan recognition protein LCprovided by FlyBase
Primary source: FLYBASE:FBgn0035976
Locus tag: Dmel_CG4432
See related: AllianceGenome:FB:FBgn0035976
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: (PGRP)-LC; CG4432; Dm PGRP-LC; Dmel\CG4432; ird7; pgrp; pgrp lc; pgrp-lc; Pgrp-LC; PGRP-LCa; PGRP-LCd; PGRP-LCx; PGRPLC; tot
Summary: Enables peptidoglycan binding activity and peptidoglycan immune receptor activity. Involved in defense response to other organism; regulation of defense response; and regulation of synaptic plasticity. Located in apicolateral plasma membrane; cytoplasmic vesicle; and presynapse. Is integral component of plasma membrane. Is expressed in adult Malpighian tubule; embryonic dorsal epidermis; embryonic large intestine; embryonic ventral epidermis; and embryonic/larval lymph gland. Orthologous to human PGLYRP2 (peptidoglycan recognition protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 67B1-67B1; 3-29 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (9338810..9348336)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (9331910..9341436)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

cleaning behavior can be triggered through recognition of DAP-type PGN by its receptor PGRP-LC.
Title: The gram-negative sensing receptor PGRP-LC contributes to grooming induction in Drosophila.
Protofibrils of peptidoglycan receptors PGRP-LC and PGRP-LE seed immune deficiency protein (Imd) amyloid polymerization via Imd RIP homotypic interaction motif (RHIM), and the formation of functional Imd amyloid fibril is required for NF-kappaB signaling.
Title: Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-κB Signaling.
this study identifies a novel version of the peptidoglycan receptor PGRP-LC and demonstrate that it tunes immune responses to live (threatening) or dead (harmless) bacteria
Title: The regulatory isoform rPGRP-LC induces immune resolution via endosomal degradation of receptors.
PGRP-LC immune receptor regulates trans-synaptic signaling, a novel activity for innate immune signaling.
Title: The Innate Immune Receptor PGRP-LC Controls Presynaptic Homeostatic Plasticity.
Silencing TM9SF4 prevents plasma membrane localization of PGRP-LC, whereas silencing TM9SF2 does not, which may account for the non-redundant role of TM9SF4 in phagocytosis of Gram-negative bacteria.
Title: The nonaspanins TM9SF2 and TM9SF4 regulate the plasma membrane localization and signalling activity of the peptidoglycan recognition protein PGRP-LC in Drosophila.
The steroid hormone ecdysone controls the expression of the pattern recognition receptor PGRP-LC in Drosophila, thereby tightly regulating innate immune recognition and defense against bacterial infection.
Title: Ecdysone triggered PGRP-LC expression controls Drosophila innate immunity.
our study delineates how a combination of extracellular sensing by PGRP-LC isoforms and intracellular sensing through PGRP-LE provides sophisticated mechanisms to detect and differentiate between infections in Drosophila.
Title: Tissue- and ligand-specific sensing of gram-negative infection in drosophila by PGRP-LC isoforms and PGRP-LE.
The authors show that stimulation of the Drosophila pattern recognition protein PGRP-LCx induces DIAP2-dependent polyubiquitylation of the initiator caspase DREDD.
Title: Ubiquitylation of the initiator caspase DREDD is required for innate immune signalling.
Data show that the Drosophila peptidoglycan-recognition protein LF interacts with peptidoglycan-recognition protein LC to downregulate the Imd pathway.
Title: The Drosophila peptidoglycan-recognition protein LF interacts with peptidoglycan-recognition protein LC to downregulate the Imd pathway.
PGRP-LE and PGRP-LC play a crucial role in detecting extracellular and intracellular bacteria with DAP-type peptidoglycans to induce various innate immune responses
Title: Extracellular and intracellular pathogen recognition by Drosophila PGRP-LE and PGRP-LC.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
NOT enables N-acetylmuramoyl-L-alanine amidase activity	IKR Inferred from Key Residues more info	PubMed
enables lipopolysaccharide immune receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables peptidoglycan binding	IDA Inferred from Direct Assay more info	PubMed
enables peptidoglycan binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables peptidoglycan immune receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables peptidoglycan immune receptor activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-negative bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in peptidoglycan catabolic process	IKR Inferred from Key Residues more info	PubMed
involved_in peptidoglycan recognition protein signaling pathway	HMP more info	PubMed
involved_in peptidoglycan recognition protein signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidoglycan recognition protein signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in peptidoglycan recognition protein signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of antibacterial peptide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria	HMP more info	PubMed
involved_in positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of humoral immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of melanization defense response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apicolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: peptidoglycan recognition protein LC

Names: CG4432-PA; CG4432-PB; CG4432-PC; CG4432-PD; CG4432-PE; CG4432-PG; CG4432-PH; CG4432-PI; CG4432-PJ; CG4432-PK; PG recognition receptor-LC; PGRP-LC-PA; PGRP-LC-PB; PGRP-LC-PC; PGRP-LC-PD; PGRP-LC-PE; PGRP-LC-PG; PGRP-LC-PH; PGRP-LC-PI; PGRP-LC-PJ; PGRP-LC-PK; Peptidoglycan-recognition protein-LC; immune response deficient 7; peptidoglycan recognition protein-LC; totem

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

9338810..9348336

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001169925.1 → NP_001163396.1 peptidoglycan recognition protein LC, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163396.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JI88

Conserved Domains (1) summary

smart00701
Location:340 → 476

PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
NM_140041.4 → NP_648298.1 peptidoglycan recognition protein LC, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_648298.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q1EBX6, Q7YW58, Q8T5Q2, Q9GNK5, Q9VSV9

UniProtKB/TrEMBL

M9NDN2

Related

FBpp0088492

Conserved Domains (1) summary

smart00701
Location:356 → 490

PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
NM_206308.4 → NP_996030.1 peptidoglycan recognition protein LC, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996030.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9GNK5

Conserved Domains (1) summary

smart00701
Location:337 → 476

PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
NM_001316438.1 → NP_001303367.1 peptidoglycan recognition protein LC, isoform I [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0S0WMR4

Conserved Domains (1) summary

smart00701
Location:337 → 471

PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
NM_001169927.2 → NP_001163398.1 peptidoglycan recognition protein LC, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163398.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JI87
NM_168324.4 → NP_729468.2 peptidoglycan recognition protein LC, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729468.2

Status: REVIEWED

UniProtKB/TrEMBL

E1JI88

Related

FBpp0088491

Conserved Domains (1) summary

smart00701
Location:340 → 476

PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
NM_001259764.1 → NP_001246693.1 peptidoglycan recognition protein LC, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246693.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q1EBX6, Q7YW58, Q8T5Q2, Q9GNK5, Q9VSV9

UniProtKB/TrEMBL

M9NDN2

Conserved Domains (1) summary

smart00701
Location:356 → 490

PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
NM_001363933.1 → NP_001350860.1 peptidoglycan recognition protein LC, isoform K [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2U8U141

Conserved Domains (2) summary

smart00701
Location:166 → 300

PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme

cl22851
Location:9 → 62

PHD_SF; PHD finger superfamily
NM_001363932.1 → NP_001350859.1 peptidoglycan recognition protein LC, isoform J [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2U8U0I3

Conserved Domains (2) summary

smart00701
Location:166 → 305

PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme

cl22851
Location:9 → 62

PHD_SF; PHD finger superfamily
NM_001169926.2 → NP_001163397.1 peptidoglycan recognition protein LC, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163397.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JI89

Conserved Domains (2) summary

smart00701
Location:169 → 305

PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme

cl22851
Location:9 → 62

PHD_SF; PHD finger superfamily

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A0A0S0WMR4		A0A0S0WMR4
A0A2U8U0I3		A0A2U8U0I3
A0A2U8U141		A0A2U8U141
E1JI87		E1JI87
E1JI88		E1JI88
E1JI89		E1JI89
M9NDN2		M9NDN2
Q9GNK5.1		Q9GNK5