ahcy adenosylhomocysteinase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ahcyprovided by ZNC
Official Full Name: adenosylhomocysteinaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-031219-6
See related: Ensembl:ENSDARG00000005191 AllianceGenome:ZFIN:ZDB-GENE-031219-6
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: D150; cb1079; ducttrip; hm:zeh1173; hm:zeh1364; wu:fj67b02
Summary: Predicted to enable adenosylhomocysteinase activity. Acts upstream of or within S-adenosylmethionine cycle. Predicted to be active in cytosol. Is expressed in several structures, including brain; digestive system; immature eye; musculature system; and neural tube. Used to study metabolic dysfunction-associated steatotic liver disease and steatotic liver disease. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm and hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase. Orthologous to human AHCY (adenosylhomocysteinase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (49926115..49966288)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (49927462..49967635)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hepatic steatosis and liver degeneration are prominent features of the ducttrip (dtp) mutant phenotype. Positional cloning identified a causative mutation in the gene encoding S-adenosylhomocysteine hydrolase (Ahcy).
Title: TNFalpha-dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish S-adenosylhomocysteine hydrolase.
AHCYL1 has a different function from AHCY and plays an important role in embryogenesis by modulating inositol 1,4,5-trisphosphate receptor function for the intracellular calcium release
Title: Suppression and overexpression of adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) influences zebrafish embryo development: a possible role for AHCYL1 in inositol phospholipid signaling.

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General gene information

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Markers

fj67b02.x1 (e-PCR)
- UniSTS:199819

fb34g03.x1 (e-PCR)
- UniSTS:190447

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables adenosylhomocysteinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenosylhomocysteinase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in S-adenosylmethionine cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within S-adenosylmethionine cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within one-carbon metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: adenosylhomocysteinase

Names: S-adenosylhomocysteine hydrolase; dtp

NP_954688.1

EC 3.13.2.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199218.1 → NP_954688.1 adenosylhomocysteinase

See identical proteins and their annotated locations for NP_954688.1

Status: PROVISIONAL

Source sequence(s)

AY398307

UniProtKB/TrEMBL

B2GPY3, F6NTZ3, Q803T5

Related

ENSDARP00000002844.7, ENSDART00000018523.9

Conserved Domains (2) summary

PRK05476
Location:1 → 427

PRK05476; S-adenosyl-L-homocysteine hydrolase; Provisional

pfam05221
Location:6 → 432

AdoHcyase; S-adenosyl-L-homocysteine hydrolase