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    RASL11A RAS like family 11 member A [ Homo sapiens (human) ]

    Gene ID: 387496, updated on 2-Nov-2024

    Summary

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    Official Symbol
    RASL11Aprovided by HGNC
    Official Full Name
    RAS like family 11 member Aprovided by HGNC
    Primary source
    HGNC:HGNC:23802
    See related
    Ensembl:ENSG00000122035 MIM:612403; AllianceGenome:HGNC:23802
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable G protein activity and GTP binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase I. Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in fat (RPKM 15.1), colon (RPKM 11.1) and 24 other tissues See more
    Orthologs
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    Genomic context

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    See RASL11A in Genome Data Viewer
    Location:
    13q12.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (27270830..27275192)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (26491553..26495914)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (27844967..27849329)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 102 Neighboring gene ribosomal protein L21 Neighboring gene small nucleolar RNA, H/ACA box 27 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:27844429-27844929 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5199 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:27909191-27910390 Neighboring gene RNA, U6 small nuclear 70, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7502 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:27936491-27936992 Neighboring gene uncharacterized LOC105370126 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:27947836-27949035

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Induced Chromosomal Aneuploidy Results in Global and Consistent Deregulation of the Transcriptome of Cancer Cells. Wangsa D, et al. Neoplasia, 2019 Jul. PMID 31174021, Free PMC Article
    2. Chromatin association and regulation of rDNA transcription by the Ras-family protein RasL11a. Pistoni M, et al. EMBO J, 2010 Apr 7. PMID 20168301, Free PMC Article
    3. RASL11A, member of a novel small monomeric GTPase gene family, is down-regulated in prostate tumors. Louro R, et al. Biochem Biophys Res Commun, 2004 Apr 9. PMID 15033445
    4. HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis. Fujimoto M, et al. Nat Commun, 2022 Jul 29. PMID 35906200, Free PMC Article
    5. Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. One gene, RASL11A, localized on chromosome band 13q12.2, escaped the copy number-induced overexpression and was reproducibly and significantly down-regulated on the mRNA and protein level (P=.0001, FDR=0.002). RASL11A expression levels were also lower in primary colorectal tumors as compared to matched normal mucosa (P=.0001, FDR=0.0001
      Title: Induced Chromosomal Aneuploidy Results in Global and Consistent Deregulation of the Transcriptome of Cancer Cells.
    2. In transient transfection experiments, RasL11a enhanced the transcriptional activity of an RNA polymerase I-specific reporter controlled by the rDNA enhancer/promoter region.
      Title: Chromatin association and regulation of rDNA transcription by the Ras-family protein RasL11a.
    3. RASL11A is down-regulated in prostate tumors as measured by quantitative real-time PCR. This result suggests that this gene may have a tumor suppressor role in prostate cancer.
      Title: RASL11A, member of a novel small monomeric GTPase gene family, is down-regulated in prostate tumors.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ras-like protein family member 11A
    NP_001318055.1
    NP_996563.1
    XP_024305115.1
    XP_054230491.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001331126.2 → NP_001318055.1  ras-like protein family member 11A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL159977
      UniProtKB/Swiss-Prot
      Q6T310
      Conserved Domains (1) summary
      cd04146
      Location:1 → 156
      RERG_RasL11_like; Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families

    2. NM_206827.2 → NP_996563.1  ras-like protein family member 11A isoform 1

      See identical proteins and their annotated locations for NP_996563.1

      Status: VALIDATED

      Source sequence(s)
      AL159977
      Consensus CDS
      CCDS9321.1
      UniProtKB/Swiss-Prot
      B2RN97, Q6T310
      Related
      ENSP00000241463.5, ENST00000241463.5
      Conserved Domains (1) summary
      cd04146
      Location:29 → 198
      RERG_RasL11_like; Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      27270830..27275192
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024449347.2 → XP_024305115.1  ras-like protein family member 11A isoform X1

      Conserved Domains (1) summary
      cd04146
      Location:1 → 156
      RERG_RasL11_like; Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      26491553..26495914
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374516.1 → XP_054230491.1  ras-like protein family member 11A isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6T310.1 GenPept UniProtKB/Swiss-Prot:Q6T310

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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