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    S6k Ribosomal protein S6 kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38654, updated on 2-Nov-2024

    Summary

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    Official Symbol
    S6kprovided by FlyBase
    Official Full Name
    Ribosomal protein S6 kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0283472
    Locus tag
    Dmel_CG10539
    See related
    AllianceGenome:FB:FBgn0283472
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    10539; 7-10; 7084; CG10539; d-S6K; Dmel\CG10539; dp70s6k; dP70S6K; Dp70s6k; Dp70S6k; dp70[S6k]; Dp70[s6k]; dps6k; ds6k; dS6k; dS6K; DS6K; dS6K1; fs(3)07084; l(3)07084; p-S6K; p70 S6K; p70/S6K; p70s6K; p70S6k; p70S6K; p70[S6 kinase]; p70[S6kinase]; p70[S6k]; p70[S6K]; Pk64F; Pk?6; pS6K; S6; S6 K; s6k; S6K; S6K1; s6k11
    Summary
    Enables ribosomal protein S6 kinase activity. Involved in several processes, including TORC1 signaling; cell surface receptor protein tyrosine kinase signaling pathway; and nervous system development. Located in presynaptic active zone. Is expressed in adult brain and adult head. Used to study alcohol dependence; glucose metabolism disease; and type 2 diabetes mellitus. Orthologous to human RPS6KB1 (ribosomal protein S6 kinase B1) and RPS6KB2 (ribosomal protein S6 kinase B2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See S6k in Genome Data Viewer
    Location:
    64E8-64E11; 3-15 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5797549..5810931, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5790649..5804031, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Bre1 Neighboring gene Tektin C Neighboring gene uncharacterized protein Neighboring gene krishah Neighboring gene mad2 Neighboring gene vein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila p70s6k homolog exhibits conserved regulatory elements and rapamycin sensitivity. Stewart MJ, et al. Proc Natl Acad Sci U S A, 1996 Oct 1. PMID 8855259, Free PMC Article
    2. Age- and diet-specific effects of variation at S6 kinase on life history, metabolic, and immune response traits in Drosophila melanogaster. Cho I, et al. DNA Cell Biol, 2010 Sep. PMID 20491566, Free PMC Article
    3. Comparative idiosyncrasies in life extension by reduced mTOR signalling and its distinctiveness from dietary restriction. Garratt M, et al. Aging Cell, 2016 Aug. PMID 27139919, Free PMC Article
    4. Nuclear gating of a Drosophila dCREB2 activator is involved in memory formation. Fropf R, et al. Neurobiol Learn Mem, 2013 Nov. PMID 24076014, Free PMC Article
    5. Rapamycin increases mitochondrial efficiency by mtDNA-dependent reprogramming of mitochondrial metabolism in Drosophila. Villa-Cuesta E, et al. J Cell Sci, 2014 May 15. PMID 24610944, Free PMC Article

    See all (543) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Glutamine stimulates the S6K/4E-BP branch of insulin signalling pathway to mitigate human poly(Q) disorders in Drosophila disease models.
      Title: Glutamine stimulates the S6K/4E-BP branch of insulin signalling pathway to mitigate human poly(Q) disorders in Drosophila disease models.
    2. Inhibition of S6K lowers age-related inflammation and increases lifespan through the endolysosomal system.
      Title: Inhibition of S6K lowers age-related inflammation and increases lifespan through the endolysosomal system.
    3. Identification of PP2A and S6 Kinase as Modifiers of Leucine-Rich Repeat Kinase-Induced Neurotoxicity.
      Title: Identification of PP2A and S6 Kinase as Modifiers of Leucine-Rich Repeat Kinase-Induced Neurotoxicity.
    4. The S6k/4E-BP mediated growth promoting sub-pathway of insulin signalling cascade is essential to restrict pathogenesis of poly(Q) disorders in Drosophila.
      Title: The S6k/4E-BP mediated growth promoting sub-pathway of insulin signalling cascade is essential to restrict pathogenesis of poly(Q) disorders in Drosophila.
    5. mTOR-S6K1 pathway mediates cytoophidium assembly
      Title: mTOR-S6K1 pathway mediates cytoophidium assembly.
    6. Findings indicate that Archipelago (Ago)/FBXW7 controls S6kinase (dS6K) protein levels, but do not impinge on the transcript level.
      Title: A Drosophila genetic screen for suppressors of S6kinase-dependent growth identifies the F-box subunit Archipelago/FBXW7.
    7. MYC and S6K cooperate through coordinate activation of the essential Pol I transcription initiation factor TIF-1A.
      Title: S6 Kinase is essential for MYC-dependent rDNA transcription in Drosophila.
    8. This study showed that p70 S6 kinase (S6k), acting downstream of the insulin receptor (InR) and the small GTPase Arf6, is a key mediator of ethanol-induced sedation in Drosophila
      Title: S6 Kinase Reflects and Regulates Ethanol-Induced Sedation.
    9. our results indicate that S6K1 has an inhibitory effect on autophagic activity under normal nutritional conditions
      Title: TAK1 regulates autophagic cell death by suppressing the phosphorylation of p70 S6 kinase 1.
    10. S6 kinase localizes to the presynaptic active zone and functions with PDK1 to control synapse development
      Title: S6 kinase localizes to the presynaptic active zone and functions with PDK1 to control synapse development.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal protein S6 kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribosomal protein S6 kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in TORC1 signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to amino acid stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to insulin stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female germ-line stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in insulin receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell size IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of response to drug IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of terminal button organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vascular endothelial growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vascular endothelial growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in nucleoplasm HDA PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ribosomal protein S6 kinase
    Names
    CG10539-PA
    CG10539-PB
    RPS6-p70-protein kinase
    S6 kinase
    S6-kinase
    S6K kinase
    S6k-PA
    S6k-PB
    S6kinase
    dS6 kinase
    p70 S6 kinase
    p70 S6 kinase 1
    p70 ribosomal S6 kinase
    p70S6 kinase
    p70S6K kinase
    protein kinase-like 64F
    ribosomal S6 protein kinase
    NP_001261450.1
    NP_523941.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      5797549..5810931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274521.1 → NP_001261450.1  ribosomal protein S6 kinase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261450.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H1ZYE3, Q94533
      Conserved Domains (2) summary
      PTZ00263
      Location:76 → 397
      PTZ00263; protein kinase A catalytic subunit; Provisional
      cd05584
      Location:81 → 402
      STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

    2. NM_079217.3 → NP_523941.2  ribosomal protein S6 kinase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523941.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H1ZYE3, Q94533
      Related
      FBpp0076820
      Conserved Domains (2) summary
      PTZ00263
      Location:76 → 397
      PTZ00263; protein kinase A catalytic subunit; Provisional
      cd05584
      Location:81 → 402
      STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P91656 P91656
    Q8SWT5 Q8SWT5
    Q94533 Q94533

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