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    Cip4 Cdc42-interacting protein 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38534, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Cip4provided by FlyBase
    Official Full Name
    Cdc42-interacting protein 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0035533
    Locus tag
    Dmel_CG15015
    See related
    AllianceGenome:FB:FBgn0035533
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11341; CG15015; cip4; CIP4; dcip4; dCIP4; DCIP4; Dmel\CG15015
    Summary
    Enables GTPase activating protein binding activity and lipid binding activity. Involved in several processes, including epithelial cell differentiation; negative regulation of cellular component organization; and plasma membrane tubulation. Located in several cellular components, including cleavage furrow; midbody; and neuromuscular junction. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; central nervous system; embryonic/larval digestive system; and extended germ band embryo. Orthologous to human FNBP1 (formin binding protein 1); FNBP1L (formin binding protein 1 like); and TRIP10 (thyroid hormone receptor interactor 10). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Cip4 in Genome Data Viewer
    Location:
    64B1-64B2; 3-12 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4322491..4364102, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4322491..4364102, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene claspin Neighboring gene Peroxisomal Membrane Protein 34 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45156 Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein S6 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deficiency of X-linked inverted duplicates with male-biased expression and the underlying evolutionary mechanisms in the Drosophila genome. Chen ZX, et al. Mol Biol Evol, 2011 Oct. PMID 21546357, Free PMC Article
    2. RNAi Screen in Tribolium Reveals Involvement of F-BAR Proteins in Myoblast Fusion and Visceral Muscle Morphogenesis in Insects. Schultheis D, et al. G3 (Bethesda), 2019 Apr 9. PMID 30733382, Free PMC Article
    3. Cooperative functions of the two F-BAR proteins Cip4 and Nostrin in the regulation of E-cadherin in epithelial morphogenesis. Zobel T, et al. J Cell Sci, 2015 Feb 1. PMID 25413347
    4. WHAMY is a novel actin polymerase promoting myoblast fusion, macrophage cell motility and sensory organ development in Drosophila. Brinkmann K, et al. J Cell Sci, 2016 Feb 1. PMID 26675239
    5. Formation of membrane ridges and scallops by the F-BAR protein Nervous Wreck. Becalska AN, et al. Mol Biol Cell, 2013 Aug. PMID 23761074, Free PMC Article

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cip4 initially promotes membrane invagination and early-actin-based endosomal motility, and Nostrin makes contacts with microtubules through the kinesin Khc-73 for trafficking of recycling endosomes.
      Title: Cooperative functions of the two F-BAR proteins Cip4 and Nostrin in the regulation of E-cadherin in epithelial morphogenesis.
    2. The F-BAR protein Cip4/Toca-1 antagonizes the formin Diaphanous in membrane stabilization and compartmentalization.
      Title: The F-BAR protein Cip4/Toca-1 antagonizes the formin Diaphanous in membrane stabilization and compartmentalization.
    3. This study proposed that dCIP4 restrains synaptic growth by inhibiting postsynaptic Glass bottom boat secretion through the Wsp-Arp2/3 pathway.
      Title: dCIP4 (Drosophila Cdc42-interacting protein 4) restrains synaptic growth by inhibiting the secretion of the retrograde Glass bottom boat signal.
    4. Cip4 integrates membrane trafficking and actin dynamics through WASP and WAVE.
      Title: Drosophila Cip4/Toca-1 integrates membrane trafficking and actin dynamics through WASP and SCAR/WAVE.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c4361901-4361048 mobile_element_type = transposon:FB{}Cip4[FB]

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activating protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables lipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phospholipid binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellularization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germarium-derived female germ-line cyst encapsulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing hair organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mesoderm development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of actin nucleation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plasma membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plasma membrane tubulation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in plasma membrane tubulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of adherens junction organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synaptic assembly at neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Cdc42-interacting protein 4
    Names
    CG15015-PA
    CG15015-PB
    CG15015-PC
    CG15015-PD
    CG15015-PE
    CG15015-PF
    CG15015-PG
    CG15015-PH
    CG15015-PI
    CG15015-PJ
    CG15015-PK
    Cdc42-Interacting protein 4
    Cip4-PA
    Cip4-PB
    Cip4-PC
    Cip4-PD
    Cip4-PE
    Cip4-PF
    Cip4-PG
    Cip4-PH
    Cip4-PI
    Cip4-PJ
    Cip4-PK

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4322491..4364102 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274483.1 → NP_001261412.1  Cdc42-interacting protein 4, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261412.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PBP3, Q8SYR8
      Conserved Domains (3) summary
      cd07653
      Location:35 → 285
      F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
      cd11619
      Location:369 → 445
      HR1_CIP4-like; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Cdc42-Interacting Protein 4 and similar proteins
      cd11911
      Location:540 → 598
      SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4

    2. NM_001274484.1 → NP_001261413.1  Cdc42-interacting protein 4, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261413.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PE52, Q8SYR8
      Conserved Domains (3) summary
      cd07653
      Location:35 → 285
      F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
      cd11619
      Location:378 → 454
      HR1_CIP4-like; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Cdc42-Interacting Protein 4 and similar proteins
      cd11911
      Location:549 → 607
      SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4

    3. NM_001259690.2 → NP_001246619.1  Cdc42-interacting protein 4, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246619.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NE16, Q8SYR8
      Conserved Domains (3) summary
      cd07653
      Location:35 → 285
      F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
      cd11619
      Location:378 → 454
      HR1_CIP4-like; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Cdc42-Interacting Protein 4 and similar proteins
      cd11911
      Location:550 → 608
      SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4

    4. NM_001259688.2 → NP_001246617.1  Cdc42-interacting protein 4, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246617.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NF07, Q8SYR8
      Conserved Domains (3) summary
      cd07653
      Location:35 → 285
      F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
      cd11619
      Location:390 → 466
      HR1_CIP4-like; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Cdc42-Interacting Protein 4 and similar proteins
      cd11911
      Location:561 → 619
      SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4

    5. NM_001259687.2 → NP_001246616.1  Cdc42-interacting protein 4, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246616.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9ND42, Q8SYR8
      Conserved Domains (3) summary
      cd07653
      Location:35 → 285
      F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
      cd11619
      Location:390 → 466
      HR1_CIP4-like; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Cdc42-Interacting Protein 4 and similar proteins
      cd11911
      Location:582 → 640
      SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4

    6. NM_001259691.2 → NP_001246620.1  Cdc42-interacting protein 4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246620.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NE16, Q8SYR8
      Conserved Domains (3) summary
      cd07653
      Location:35 → 285
      F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
      cd11619
      Location:378 → 454
      HR1_CIP4-like; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Cdc42-Interacting Protein 4 and similar proteins
      cd11911
      Location:550 → 608
      SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4

    7. NM_139636.4 → NP_647893.2  Cdc42-interacting protein 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647893.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYR8, Q9VZD7
      Related
      FBpp0073195
      Conserved Domains (3) summary
      cd07653
      Location:35 → 285
      F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
      cd11619
      Location:378 → 454
      HR1_CIP4-like; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Cdc42-Interacting Protein 4 and similar proteins
      cd11911
      Location:569 → 627
      SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4

    8. NM_001259693.2 → NP_001246622.1  Cdc42-interacting protein 4, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246622.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NF10, Q8SYR8
      Conserved Domains (3) summary
      cd07653
      Location:35 → 285
      F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
      cd11619
      Location:390 → 466
      HR1_CIP4-like; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Cdc42-Interacting Protein 4 and similar proteins
      cd11911
      Location:562 → 620
      SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4

    9. NM_001259692.1 → NP_001246621.1  Cdc42-interacting protein 4, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246621.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9ND44, Q8SYR8
      Conserved Domains (3) summary
      cd07653
      Location:69 → 319
      F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
      cd11619
      Location:412 → 488
      HR1_CIP4-like; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Cdc42-Interacting Protein 4 and similar proteins
      cd11911
      Location:584 → 642
      SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4

    10. NM_001104031.2 → NP_001097501.1  Cdc42-interacting protein 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097501.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNK4, Q8SYR8
      Conserved Domains (3) summary
      cd07653
      Location:69 → 319
      F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
      cd11619
      Location:412 → 488
      HR1_CIP4-like; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Cdc42-Interacting Protein 4 and similar proteins
      cd11911
      Location:603 → 661
      SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4

    11. NM_001259689.1 → NP_001246618.1  Cdc42-interacting protein 4, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246618.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NDH6, Q8SYR8
      Conserved Domains (3) summary
      cd07653
      Location:32 → 281
      F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
      cd11619
      Location:374 → 450
      HR1_CIP4-like; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Cdc42-Interacting Protein 4 and similar proteins
      cd11911
      Location:566 → 624
      SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JNK4 A8JNK4
    M9ND42 M9ND42
    M9ND44 M9ND44
    M9NDH6 M9NDH6
    M9NE16 M9NE16
    M9NF07 M9NF07
    M9NF10 M9NF10
    M9PBP3 M9PBP3
    M9PE52 M9PE52
    Q8SYR8 Q8SYR8
    Q95SC6 Q95SC6
    Q9VZD7 Q9VZD7

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