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    Tcaim T cell activation inhibitor, mitochondrial [ Mus musculus (house mouse) ]

    Gene ID: 382117, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tcaimprovided by MGI
    Official Full Name
    T cell activation inhibitor, mitochondrialprovided by MGI
    Primary source
    MGI:MGI:1196217
    See related
    Ensembl:ENSMUSG00000046603 AllianceGenome:MGI:1196217
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1129; TOAG-1; D9Ertd402e
    Summary
    Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and respiratory system. Orthologous to human TCAIM (T cell activation inhibitor, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 4.1), kidney adult (RPKM 3.1) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tcaim in Genome Data Viewer
    Location:
    9 F4; 9 73.14 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (122634586..122665397)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (122805513..122838924)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51699 Neighboring gene testis and ovary specific PAZ domain containing 1 Neighboring gene STARR-positive B cell enhancer mm9_chr9:122694321-122694622 Neighboring gene STARR-positive B cell enhancer ABC_E6814 Neighboring gene predicted gene, 35549 Neighboring gene zinc finger protein 445 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:122775118-122775301 Neighboring gene zinc finger with KRAB and SCAN domains 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TCAIM decreases T cell priming capacity of dendritic cells by inhibiting TLR-induced Ca2+ influx and IL-2 production. Vogel SZ, et al. J Immunol, 2015 Apr 1. PMID 25750433
    2. Expression of tolerance associated gene-1, a mitochondrial protein inhibiting T cell activation, can be used to predict response to immune modulating therapies. Keeren K, et al. J Immunol, 2009 Sep 15. PMID 19684086
    3. Identification of gene markers for the prediction of allograft rejection or permanent acceptance. Sawitzki B, et al. Am J Transplant, 2007 May. PMID 17456197
    4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TCAIM decreases T cell priming capacity of dendritic cells by inhibiting TLR-induced Ca2+ influx and IL-2 production.
      Title: TCAIM decreases T cell priming capacity of dendritic cells by inhibiting TLR-induced Ca2+ influx and IL-2 production.
    2. Downregulation of TOAG-1 and alpha-1,2-mannosidase expression occurred in graft infiltrating cells and expression of both genes was also downregulated after T-cell activation in vitro.
      Title: Identification of gene markers for the prediction of allograft rejection or permanent acceptance.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC91156

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    T-cell activation inhibitor, mitochondrial
    Names
    tolerance associated gene-1 protein
    tolerance-associated gene 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013405.3 → NP_001013423.3  T-cell activation inhibitor, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125374
      Consensus CDS
      CCDS23647.2
      UniProtKB/Swiss-Prot
      Q66JZ4
      Related
      ENSMUSP00000049759.8, ENSMUST00000052740.14

    2. NM_001408934.1 → NP_001395863.1  T-cell activation inhibitor, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125374
      UniProtKB/Swiss-Prot
      Q66JZ4

    3. NM_001408935.1 → NP_001395864.1  T-cell activation inhibitor, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125374

    4. NM_001408936.1 → NP_001395865.1  T-cell activation inhibitor, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125374

    5. NM_001408937.1 → NP_001395866.1  T-cell activation inhibitor, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125374

    6. NM_001408938.1 → NP_001395867.1  T-cell activation inhibitor, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125374

    7. NM_001408939.1 → NP_001395868.1  T-cell activation inhibitor, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125374

    8. NM_001408940.1 → NP_001395869.1  T-cell activation inhibitor, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC125374

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      122634586..122665397
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512171.5 → XP_006512234.1  T-cell activation inhibitor, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006512234.1

      UniProtKB/TrEMBL
      G3X983
      Conserved Domains (2) summary
      pfam14687
      Location:60 → 166
      DUF4460; Domain of unknown function (DUF4460)
      pfam14688
      Location:227 → 529
      DUF4461; Domain of unknown function (DUF4461)

    2. XM_017313450.3 → XP_017168939.1  T-cell activation inhibitor, mitochondrial isoform X3

      Conserved Domains (1) summary
      pfam14688
      Location:90 → 392
      DUF4461; Domain of unknown function (DUF4461)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66JZ4.1 GenPept UniProtKB/Swiss-Prot:Q66JZ4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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