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    mwh multiple wing hairs [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38131, updated on 18-Sep-2024

    Summary

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    Official Symbol
    mwhprovided by FlyBase
    Official Full Name
    multiple wing hairsprovided by FlyBase
    Primary source
    FLYBASE:FBgn0264272
    Locus tag
    Dmel_CG43772
    See related
    AllianceGenome:FB:FBgn0264272
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BP1018; CG13913; CG34022; CG43772; Dmel\CG43772; Mwh
    Old locus tag
    Dmel_CG13913; Dmel_CG34022
    Summary
    Predicted to enable actin filament binding activity. Involved in imaginal disc-derived wing hair site selection and negative regulation of actin filament polymerization. Predicted to be active in cytosol. Is expressed in dorsal epidermis primordium; embryonic/larval apodeme; epidermis; and wing. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See mwh in Genome Data Viewer
    Location:
    61F3-61F4; 3-0 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1200786..1232700)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1200786..1232700)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Lysozyme X Neighboring gene APPL-interacting protein 1 Neighboring gene meep Neighboring gene uncharacterized protein Neighboring gene Lysozyme B Neighboring gene Lysozyme C Neighboring gene Lysozyme D Neighboring gene Lysozyme E Neighboring gene Lysozyme P Neighboring gene Lysozyme S Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Relationship between lifespan and somatic mutation in D. melanogaster after treatment with chlorophyllin. Cruces MP, et al. Environ Toxicol Pharmacol, 2022 Jul. PMID 35654371
    2. Biological effects of low-dose γ-ray irradiation on chromosomes and DNA of Drosophila melanogaster. Tanaka Y, et al. J Radiat Res, 2021 Jan 1. PMID 33290547, Free PMC Article
    3. Differentiation capacities of the dorsal metathoracic (haltere) disc ofDrosophila melanogaster : I. Normal organ map. Ouweneel WJ, et al. Wilhelm Roux Arch Entwickl Mech Org, 1973 Jun. PMID 28304588
    4. Revisiting the Phylogeny of the Animal Formins: Two New Subtypes, Relationships with Multiple Wing Hairs Proteins, and a Lost Human Formin. Pruyne D. PLoS One, 2016. PMID 27695129, Free PMC Article
    5. High-throughput in vivo genotoxicity testing: an automated readout system for the somatic mutation and recombination test (SMART). Lombardot B, et al. PLoS One, 2015. PMID 25830368, Free PMC Article

    See all (256) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cells with loss-of-heterozygosity after exposure to ionizing radiation in Drosophila are culled by p53-dependent and p53-independent mechanisms.
      Title: Cells with loss-of-heterozygosity after exposure to ionizing radiation in Drosophila are culled by p53-dependent and p53-independent mechanisms.
    2. Cmb (Combover) is a novel planar cell polarity effector that promotes to wing hair formation, a function that is antagonized by Mwh.
      Title: Combover/CG10732, a novel PCP effector for Drosophila wing hair formation.
    3. multiple-wing-hairs gene encodes a novel GBD-FH3 domain-containing protein that functions both prior to and after wing hair initiati
      Title: The multiple-wing-hairs gene encodes a novel GBD-FH3 domain-containing protein that functions both prior to and after wing hair initiation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 1219647-1227237 mobile_element_type = transposon:412{}904

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cortical actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of planar polarity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing hair organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing hair site selection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of actin filament polymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    multiple wing hairs
    Names
    CG43772-PA
    CG43772-PB
    CG43772-PC
    multiple wing hair
    multiple-wing-hairs
    mwh-PA
    mwh-PB
    mwh-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1200786..1232700
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274315.1 → NP_001261244.1  multiple wing hairs, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261244.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PE53
      Conserved Domains (2) summary
      pfam06367
      Location:524 → 725
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:380 → 506
      Drf_GBD; Diaphanous GTPase-binding Domain

    2. NM_001274314.1 → NP_001261243.1  multiple wing hairs, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261243.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDL4
      Conserved Domains (2) summary
      pfam06367
      Location:523 → 724
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:379 → 505
      Drf_GBD; Diaphanous GTPase-binding Domain

    3. NM_138238.3 → NP_612082.1  multiple wing hairs, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612082.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W0J2
      Related
      FBpp0303809
      Conserved Domains (2) summary
      pfam06367
      Location:291 → 492
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:147 → 273
      Drf_GBD; Diaphanous GTPase-binding Domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PDL4 M9PDL4
    M9PE53 M9PE53
    Q9W0J2 Q9W0J2

    Gene LinkOut

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