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    Ance-5 Ance-5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37980, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Ance-5provided by FlyBase
    Official Full Name
    Ance-5provided by FlyBase
    Primary source
    FLYBASE:FBgn0035076
    Locus tag
    Dmel_CG10142
    See related
    AllianceGenome:FB:FBgn0035076
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ance-5; CG10142; Dmel\CG10142
    Summary
    Predicted to enable metallopeptidase activity. Predicted to be active in extracellular space and plasma membrane. Is expressed in adult head. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Ance-5 in Genome Data Viewer
    Location:
    60E5-60E5; 2-107 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24888628..24891023, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20776151..20778546, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43466 Neighboring gene Na,K-ATPase Interacting Neighboring gene Na channel protein 60E Neighboring gene uncharacterized protein Neighboring gene Thiamine pyrophosphate carrier protein 2 Neighboring gene Ribosomal protein L41

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ACE and ACE2: insights from Drosophila and implications for COVID-19. Herrera P, et al. Heliyon, 2021 Dec. PMID 34901515, Free PMC Article
    2. Functional conservation of the active sites of human and Drosophila angiotensin I-converting enzyme. Coates D, et al. Biochemistry, 2000 Aug 1. PMID 10913309
    3. A conserved gene cluster as a putative functional unit in insect innate immunity. Somogyi K, et al. FEBS Lett, 2010 Nov 5. PMID 20951134
    4. Socially-responsive gene expression in male Drosophila melanogaster is influenced by the sex of the interacting partner. Ellis LL, et al. Genetics, 2011 Jan. PMID 20980240, Free PMC Article
    5. RNA degradation is required for the germ-cell to maternal transition in Drosophila. Blatt P, et al. Curr Biol, 2021 Jul 26. PMID 33989522, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables metallopeptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    NOT enables peptidyl-dipeptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    NOT involved_in proteolysis IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ance-5
    Names
    Ance-5-PA
    CG10142-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24888628..24891023 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_133164.4 → NP_573392.2  Ance-5 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573392.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95U59, Q9W0Z1
      Related
      FBpp0072325
      Conserved Domains (1) summary
      cl14813
      Location:93 → 610
      GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95U59 Q95U59
    Q9W0Z1 Q9W0Z1

    Gene LinkOut

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