pkmyt1.S protein kinase, membrane associated tyrosine/threonine 1 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: pkmyt1.S
Official Full Name: protein kinase, membrane associated tyrosine/threonine 1 S homeolog
Primary source: Xenbase:XB-GENE-969856
Locus tag: XELAEV_18047881mg
See related: EnsemblRapid:ENSXLAG00005009873
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: myt1; pkmyt1
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Genomic context

Location:: chromosome: 9_10S

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10S	NC_054388.1 (108734070..108746508)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10S	NC_030741.1 (101974191..101986687)

Chromosome 9_10S - NC_054388.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that the activity of Myt1 kinase (Myt1) is predominantly responsible for the duration of the long G2 phase in the first mitotic cell cycle in Xenopus.
Title: Involvement of Myt1 kinase in the G2 phase of the first cell cycle in Xenopus laevis.
Data show that CDK1 and cyclin B synergize during oocyte maturation to inhibit Myt1 ensuring meiotic progression.
Title: A two-step inactivation mechanism of Myt1 ensures CDK1/cyclin B activation and meiosis I entry.
Study propose a model in which the appearance of active MPF complexes following increased Cyclin B synthesis causes Myt1 inhibition, upstream of the MPF/Cdc25 amplification loop.
Title: A critical balance between Cyclin B synthesis and Myt1 activity controls meiosis entry in Xenopus oocytes.
XRINGO-activated CDKs can phosphorylate specific residues in the regulatory domain of Myt1.
Title: Meiotic inactivation of Xenopus Myt1 by CDK/XRINGO, but not CDK/cyclin, via site-specific phosphorylation.
Autophosphorylation of Myt1 is a novel inhibitory mechanism that adds another layer of complexity to the phosphorylation-dependent mechanism of Myt1 regulation.
Title: Autophosphorylation of Ser66 on Xenopus Myt1 is a prerequisite for meiotic inactivation of Myt1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within meiotic cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of G2/M transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of G2/MI transition of meiotic cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of mitotic nuclear division	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

Names: MYT1 kinase

NP_001079935.1

EC 2.7.11.1

XP_018092679.1

EC 2.7.11.1

XP_018092680.1

EC 2.7.11.1

XP_018092681.1

EC 2.7.11.1

XP_041433558.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001086466.1 → NP_001079935.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

See identical proteins and their annotated locations for NP_001079935.1

Status: PROVISIONAL

Source sequence(s)

BC057703

UniProtKB/Swiss-Prot

Q91618

UniProtKB/TrEMBL

A0A1L8ER94, A0A974BW53

Related

ENSXLAP00005029019.1, ENSXLAT00005029759.1

Conserved Domains (1) summary

cd14050
Location:101 → 351

PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054388.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

108734070..108746508

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_018237192.2 → XP_018092681.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1

UniProtKB/Swiss-Prot

Q91618

UniProtKB/TrEMBL

A0A1L8ER94, A0A974BW53

Conserved Domains (1) summary

cd14050
Location:101 → 351

PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1
XM_018237190.2 → XP_018092679.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1

UniProtKB/Swiss-Prot

Q91618

UniProtKB/TrEMBL

A0A1L8ER94, A0A974BW53

Conserved Domains (1) summary

cd14050
Location:101 → 351

PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1
XM_018237191.2 → XP_018092680.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1

UniProtKB/Swiss-Prot

Q91618

UniProtKB/TrEMBL

A0A1L8ER94, A0A974BW53

Conserved Domains (1) summary

cd14050
Location:101 → 351

PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1
XM_041577624.1 → XP_041433558.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1

UniProtKB/Swiss-Prot

Q91618

UniProtKB/TrEMBL

A0A1L8ER94, A0A974BW53

Conserved Domains (1) summary

cd14050
Location:101 → 351

PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1