cdc20.S cell division cycle 20 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: cdc20.S
Official Full Name: cell division cycle 20 S homeolog
Primary source: Xenbase:XB-GENE-17342063
Locus tag: XELAEV_18025163mg
See related: EnsemblRapid:ENSXLAG00005012766 AllianceGenome:Xenbase:XB-GENE-17342063
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: X-FZY; cdc20; fizzy1
Summary: Predicted to enable anaphase-promoting complex binding activity and ubiquitin ligase activator activity. Predicted to act upstream of or within anaphase-promoting complex-dependent catabolic process; cell division; and positive regulation of protein metabolic process. Predicted to be part of anaphase-promoting complex. Orthologous to human CDC20 (cell division cycle 20). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 4S

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4S	NC_054378.1 (68900847..68909889)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4S	NC_030731.1 (62673915..62682993)

Chromosome 4S - NC_054378.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CaN contributes to timely APC/C activation at fertilization by both negatively regulating the APC/C inhibitory activity of XErp1 and positively regulating the APC/C-activating function of Cdc20.
Title: Calcineurin promotes APC/C activation at meiotic exit by acting on both XErp1 and Cdc20.
A role for fizzy/cdc20 family of proteins in activation of APC/C distinct from substrate recruitment iss reported.
Title: A role for the Fizzy/Cdc20 family of proteins in activation of the APC/C distinct from substrate recruitment.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables anaphase-promoting complex binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin ligase activator activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anaphase-promoting complex-dependent catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of anaphase-promoting complex-dependent catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of anaphase-promoting complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cell division cycle 20 S homeolog

Names: cell division cycle 20 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001085974.1 → NP_001079443.1 cell division cycle 20 S homeolog

See identical proteins and their annotated locations for NP_001079443.1

Status: PROVISIONAL

Source sequence(s)

BC042288

UniProtKB/TrEMBL

A0A974D1V1, A0A974HNR2, Q8AVG7

Related

ENSXLAP00005037532.1, ENSXLAT00005038443.1

Conserved Domains (3) summary

COG2319
Location:190 → 494

WD40; WD40 repeat [General function prediction only]

cd00200
Location:197 → 479

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:236 → 276

7WD40; WD40 repeat [structural motif]