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    ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) [ Gallus gallus (chicken) ]

    Gene ID: 378932, updated on 17-Aug-2024

    Summary

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    Symbol
    ITGA5provided by CGNC
    Full Name
    integrin, alpha 5 (fibronectin receptor, alpha polypeptide)provided by CGNC
    Primary source
    CGNC:49148
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See ITGA5 in Genome Data Viewer
    Location:
    chromosome: 34
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 34 NC_052565.1 (726940..740914)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 34 NC_052606.1 (675777..683594)

    Chromosome 34 - NC_052565.1Genomic Context describing neighboring genes Neighboring gene NCK associated protein 1 like Neighboring gene gametocyte specific factor 2 Neighboring gene zinc finger protein 385A Neighboring gene coatomer protein complex subunit zeta 1 Neighboring gene microRNA mir-148b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sensory neuron subtypes have unique substratum preference and receptor expression before target innervation. Guan W, et al. J Neurosci, 2003 Mar 1. PMID 12629182, Free PMC Article
    2. Enhancement of ovarian tumor detection with αvβ3 integrin-targeted ultrasound molecular imaging agent in laying hens: a preclinical model of spontaneous ovarian cancer. Barua A, et al. Int J Gynecol Cancer, 2014 Jan. PMID 24304684
    3. Cranial neural crest recycle surface integrins in a substratum-dependent manner to promote rapid motility. Strachan LR, et al. J Cell Biol, 2004 Nov 8. PMID 15520227, Free PMC Article
    4. Communication between integrin receptors facilitates epicardial cell adhesion and matrix organization. Pae SH, et al. Dev Dyn, 2008 Apr. PMID 18351655

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that cooperation between alpha(4)beta(1)/alpha(5)beta(1) and RGD integrins is important for epicardial mesothelial cell adhesion and subepicardial matrix formation.
      Title: Communication between integrin receptors facilitates epicardial cell adhesion and matrix organization.
    2. alphavbeta3 integrin-targeted imaging agent enhances the visualization of ovarian tumor-associated angiogenic microvessels in hens with early-stage ovarian cancer.
      Title: Enhancement of ovarian tumor detection with αvβ3 integrin-targeted ultrasound molecular imaging agent in laying hens: a preclinical model of spontaneous ovarian cancer.
    3. On laminin, neural crest cells accumulated internalized integrin alpha 6 laminin receptors but not integrin alpha 5 fibronectin receptors; rapid cranial NCC motility on laminin requires integrin recycling
      Title: Cranial neural crest recycle surface integrins in a substratum-dependent manner to promote rapid motility.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables integrin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell adhesion mediated by integrin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of integrin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    LOW QUALITY PROTEIN: integrin alpha-5; integrin alpha-5
    Names
    integrin alpha 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052565.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      726940..740914
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046904986.1 → XP_046760942.1  LOW QUALITY PROTEIN: integrin alpha-5 isoform X1

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052606.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      675777..683594
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040693851.2 → XP_040549785.1  integrin alpha-5 isoform X2

      Conserved Domains (1) summary
      smart00191
      Location:49 → 106
      Int_alpha; Integrin alpha (beta-propellor repeats)
    Nucleotide Protein Strain
    Heading Accession and Version

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