mmp21.L matrix metallopeptidase 21 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: mmp21.L
Official Full Name: matrix metallopeptidase 21 L homeolog
Primary source: Xenbase:XB-GENE-960307
Locus tag: XELAEV_18034590mg
See related: EnsemblRapid:ENSXLAG00005011935 AllianceGenome:Xenbase:XB-GENE-960307
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: mmp; XMMP; mmp21; mmp21-A
Summary: Predicted to enable metalloendopeptidase activity and zinc ion binding activity. Predicted to act upstream of or within determination of heart left/right asymmetry. Predicted to be located in extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human MMP21 (matrix metallopeptidase 21). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 7L

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	7L	NC_054383.1 (19832194..19843510)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	7L	NC_030736.1 (19876295..19887611)

Chromosome 7L - NC_054383.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within collagen catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within determination of heart left/right asymmetry	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within determination of left/right symmetry	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within extracellular matrix organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: matrix metalloproteinase-21

Names: MMP-21

NP_001079285.1

EC 3.4.24.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001085816.1 → NP_001079285.1 matrix metalloproteinase-21 precursor

See identical proteins and their annotated locations for NP_001079285.1

Status: PROVISIONAL

Source sequence(s)

U82541

UniProtKB/Swiss-Prot

O93470

UniProtKB/TrEMBL

B7ZRV1

Related

ENSXLAP00005035014.1, ENSXLAT00005035897.1

Conserved Domains (4) summary

cd04278
Location:206 → 362

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam00413
Location:206 → 362

Peptidase_M10; Matrixin

pfam01471
Location:105 → 130

PG_binding_1; Putative peptidoglycan binding domain

cl02471
Location:388 → 577

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...