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    PDGFB platelet derived growth factor subunit B [ Gallus gallus (chicken) ]

    Gene ID: 374128, updated on 17-Aug-2024

    Summary

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    Symbol
    PDGFBprovided by CGNC
    Full Name
    platelet derived growth factor subunit Bprovided by CGNC
    Primary source
    CGNC:9243
    See related
    Ensembl:ENSGALG00010012624
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See PDGFB in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (50759346..50777366)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (51056836..51075672)

    Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121109332 Neighboring gene small nucleolar RNA, C/D box 83A Neighboring gene ribosomal protein L3 Neighboring gene chromobox homolog 7 Neighboring gene chromobox 6 Neighboring gene neuronal pentraxin receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a chicken platelet-derived growth factor B-chain cDNA. Horiuchi H, et al. Dev Comp Immunol, 2002 Jan. PMID 11687265
    2. Tendon healing in vivo: gene expression and production of multiple growth factors in early tendon healing period. Chen CH, et al. J Hand Surg Am, 2008 Dec. PMID 19084187
    3. Involvement of vessels and PDGFB in muscle splitting during chick limb development. Tozer S, et al. Development, 2007 Jul. PMID 17553906
    4. A comprehensive collection of chicken cDNAs. Boardman PE, et al. Curr Biol, 2002 Nov 19. PMID 12445392
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. platelet-derived growth factor B (PDGF-B) gene was also minimally expressed in healing tendon
      Title: Tendon healing in vivo: gene expression and production of multiple growth factors in early tendon healing period.
    2. PDGFB promotes the production of extracellular matrix and attracts connective tissue cells to the future splitting site, allowing separation of the muscle masses during the splitting process.
      Title: Involvement of vessels and PDGFB in muscle splitting during chick limb development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables platelet-derived growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in platelet-derived growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    platelet-derived growth factor subunit B
    Names
    platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204270.5 → NP_989601.3  platelet-derived growth factor subunit B precursor

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000012
      UniProtKB/TrEMBL
      Q90W23
      Conserved Domains (2) summary
      pfam00341
      Location:104 → 187
      PDGF; PDGF/VEGF domain
      pfam04692
      Location:30 → 100
      PDGF_N; Platelet-derived growth factor, N terminal region

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      50759346..50777366
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015284373.4 → XP_015139859.3  platelet-derived growth factor subunit B isoform X1

      UniProtKB/TrEMBL
      Q90W23
      Conserved Domains (2) summary
      pfam00341
      Location:104 → 187
      PDGF; PDGF/VEGF domain
      pfam04692
      Location:30 → 100
      PDGF_N; Platelet-derived growth factor, N terminal region

    2. XM_046942932.1 → XP_046798888.1  platelet-derived growth factor subunit B isoform X1

      UniProtKB/TrEMBL
      Q90W23

    3. XM_015284377.4 → XP_015139863.3  platelet-derived growth factor subunit B isoform X1

      UniProtKB/TrEMBL
      Q90W23
      Related
      ENSGALP00010017544.1, ENSGALT00010030230.1
      Conserved Domains (2) summary
      pfam00341
      Location:104 → 187
      PDGF; PDGF/VEGF domain
      pfam04692
      Location:30 → 100
      PDGF_N; Platelet-derived growth factor, N terminal region

    4. XM_046942957.1 → XP_046798913.1  platelet-derived growth factor subunit B isoform X1

      UniProtKB/TrEMBL
      Q90W23

    5. XM_015284369.4 → XP_015139855.3  platelet-derived growth factor subunit B isoform X1

      UniProtKB/TrEMBL
      Q90W23
      Conserved Domains (2) summary
      pfam00341
      Location:104 → 187
      PDGF; PDGF/VEGF domain
      pfam04692
      Location:30 → 100
      PDGF_N; Platelet-derived growth factor, N terminal region

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      51056836..51075672
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046906403.1 → XP_046762359.1  platelet-derived growth factor subunit B isoform X1

    2. XM_046906404.1 → XP_046762360.1  platelet-derived growth factor subunit B isoform X1

    3. XM_046906402.1 → XP_046762358.1  platelet-derived growth factor subunit B isoform X1

    4. XM_046906405.1 → XP_046762361.1  platelet-derived growth factor subunit B isoform X1

    5. XM_046906401.1 → XP_046762357.1  platelet-derived growth factor subunit B isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials