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    Act57B Actin 57B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37368, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Act57Bprovided by FlyBase
    Official Full Name
    Actin 57Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000044
    Locus tag
    Dmel_CG10067
    See related
    AllianceGenome:FB:FBgn0000044
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    act 57A; ACT3; Act57; act57A; Act57A; act57b; act57B; Act57b; actin; Actin; actin-57B; Actin-57B; anon-EST:CL2c12; ArpE; BEST:RE38067; C; CG10067; CG30294; chr2R:16452771..16452966; Dmel\CG10067; M; T10
    Summary
    Involved in regulation of synapse organization. Located in plasma membrane. Is expressed in several structures, including circulatory system; embryonic/larval muscle system; gonad; mesoderm; and somatic muscle primordium. Used to study hypertrophic cardiomyopathy and hypertrophic cardiomyopathy 11. Human ortholog(s) of this gene implicated in Baraitser-Winter syndrome and autosomal dominant nonsyndromic deafness 20. Orthologous to human ACTB (actin beta) and ACTG1 (actin gamma 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Act57B in Genome Data Viewer
    Location:
    57B5-57B5; 2-92 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20944021..20946431)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16831526..16833936)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Carbonic anhydrase 15 Neighboring gene Retinal Homeobox Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene homeobrain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lysine acetylation of F-actin decreases tropomyosin-based inhibition of actomyosin activity. Schmidt W, et al. J Biol Chem, 2020 Nov 13. PMID 32873710, Free PMC Article
    2. Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy. Viswanathan MC, et al. Cell Rep, 2017 Sep 12. PMID 28903042, Free PMC Article
    3. A Drosophila model of Menkes disease reveals a role for DmATP7 in copper absorption and neurodevelopment. Bahadorani S, et al. Dis Model Mech, 2010 Jan-Feb. PMID 20038716
    4. Drosophila MEF2 is a direct regulator of Actin57B transcription in cardiac, skeletal, and visceral muscle lineages. Kelly KK, et al. Mech Dev, 2002 Jan. PMID 11744367
    5. Cryptochrome Interacts With Actin and Enhances Eye-Mediated Light Sensitivity of the Circadian Clock in Drosophila melanogaster. Schlichting M, et al. Front Mol Neurosci, 2018. PMID 30072870, Free PMC Article

    See all (200) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila MEF2 is a direct regulator of Actin57B transcription in cardiac, skeletal, and visceral muscle lineages.
      Title: Drosophila MEF2 is a direct regulator of Actin57B transcription in cardiac, skeletal, and visceral muscle lineages.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ovarian fusome organization IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    actin 57B
    Names
    Act57B-PA
    Actin-57B
    CG10067-PA
    F-actin
    actin
    actin57B

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      20944021..20946431
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079076.4 → NP_523800.1  actin 57B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523800.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P53501, Q9W2Q0
      UniProtKB/TrEMBL
      C6TP14, C8VV69
      Related
      FBpp0071448
      Conserved Domains (1) summary
      PTZ00281
      Location:1 → 376
      PTZ00281; actin; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53501.1 P53501

    Gene LinkOut

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